{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:49:28Z","timestamp":1793803768807,"version":"4.6.1"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Umbilical vein thrombosis is a rare pregnancy complication, that is difficult to detect prenatally but can lead to poor fetal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We described a 33-year-old primiparae who was identified as having umbilical vein thrombosis by ultrasound at 21\u2009weeks gestation, and the neonate was found to have a portal vein thrombus after delivery. Following enoxaparin anticoagulant therapy, the thrombus disappeared within 4\u2009weeks. No thrombus formation occured during the 10-month follow-up, and the baby was in excellent clinical condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Owing to the poor fetal outcomes related to umbilical thrombosis, pay attention to abnormal clinical signs during prenatal ultrasound, fetal heart monitoring and counting fetal movements can help in the early identification of umbilical cord thrombosis.The findings highlight the importance of regular prenatal ultrasound evaluation, enabling early detection and monitoring of any anomalies or vascular abnormalities related to the fetal umbilical vein. Further research is warranted to explore the clinical implications and long-term outcomes associated with these findings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1281896","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T08:25:35Z","timestamp":1701851135000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: One case of umbilical vein thrombosis in the second trimester with associated portal vein thrombosis after childbirth"],"prefix":"10.3389","volume":"10","author":[{"given":"Wei-Wei","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Shu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Hua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Qin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Feng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3109\/15513818809022278","article-title":"Thrombosis of umbilical cord: analysis of 52 cases and literature review","volume":"8","author":"Heifetz","year":"1988","journal-title":"Pediatr Pathol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.placenta.2005.05.008","article-title":"Umbilical arterial thrombosis with vascular wall necrosis: Clinicopathologic findings of 11 cases","volume":"27","author":"Sato","year":"2006","journal-title":"Placenta"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/S1701-2163(16)32803-1","article-title":"Two cases of umbilical vein thrombosis, one with associated portal vein thrombosis","volume":"30","author":"Rubabaza","year":"2008","journal-title":"J Obstet Gynaecol Ca"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e737S","DOI":"10.1378\/chest.11-2308","article-title":"Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Monagle","year":"2012","journal-title":"Chest"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1080\/01443610063642","article-title":"Umbilical cord thrombosis-a cause of intrauterine demise?","volume":"20","author":"Byrd","year":"2000","journal-title":"J Obstet Gynaecol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/ajmg.1320330308","article-title":"In utero thrombosis and neonatal gangrene in an infant of diabetic mother","volume":"33","author":"Van Allen","year":"1989","journal-title":"Am J Med Genet"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1515\/jpme.1981.9.3.134","article-title":"The influence of cord complication on fetal pH, neonatal Apgar score, and the acid base state and oxygenation of the umbilical artery and vein","volume":"9","author":"Weber","year":"1981","journal-title":"J Perinatol Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0002-9378(84)80180-5","article-title":"An unusual cause of fetal distress","volume":"148","author":"Eggens","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e364","DOI":"10.1097\/MJT.0000000000000985","article-title":"Therapeutic implications of inherited thrombophilia in pregnancy","volume":"26","author":"Trasca","year":"2019","journal-title":"Am J Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.2350\/05-05-0051.1","article-title":"Umbilical cord stricture and overcoiling are common causes of fetal demise","volume":"9","author":"Peng","year":"2006","journal-title":"Pediatr Dev Pathol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2350\/12-06-1211-OA.1","article-title":"Gross umbilical cord complications are associated with placental lesions of circulatory stasis and fetal hypoxia","volume":"15","author":"Chan","year":"2012","journal-title":"Pediatr Dev Pathol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.siny.2006.02.011","article-title":"Infammatory responses in the placenta and umbilical cord","volume":"11","author":"Redline","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/5952326","article-title":"Intrauterine transfusion complicated by umbilical artery thrombosis. Case rep","volume":"2019","author":"Donepudi","year":"2019","journal-title":"Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00404-020-05910-x","article-title":"10 cases of umbilical cord thrombosis in the third trimester","volume":"304","author":"Zhu","year":"2021","journal-title":"Arch Gynecol Obstet"},{"key":"ref15","first-page":"320","article-title":"Umbilical vein thrombosis and maternal diabetes mellitus","volume":"26","author":"Fritz","year":"1981","journal-title":"J Reprod Me"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/7154560","article-title":"A case report of umbilical vein varix with thrombosis: prenatal ultrasonographic diagnosis and management","volume":"2019","author":"Matsumoto","year":"2019","journal-title":"Case Rep Obstet Gynecol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.jpeds.2006.01.051","article-title":"Portal vein thrombosis in the neonate: risk factors, course and outcome","volume":"148","author":"Morag","year":"2006","journal-title":"J Pediatr"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1281896\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T08:25:37Z","timestamp":1701851137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1281896\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":17,"alternative-id":["10.3389\/fmed.2023.1281896"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1281896","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,6]]},"article-number":"1281896"}}