{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:53:08Z","timestamp":1793055188728,"version":"4.5.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Fever can be viewed as an adaptive response to infection. Temperature control in sepsis is aimed at preventing potential harms associated with high temperature (tachycardia, vasodilation, electrolyte and water loss) and therapeutic hypothermia may be aimed at slowing metabolic activities and protecting organs from inflammation. Although high fever (&amp;gt;39.5\u00b0C) control is usually performed in critically ill patients, available cohorts and randomized controlled trials do not support its use to improve sepsis prognosis. Finally, both spontaneous and therapeutic hypothermia are associated with poor outcomes in sepsis.<\/jats:p>","DOI":"10.3389\/fmed.2023.1292468","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T10:29:49Z","timestamp":1698748189000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Temperature control in sepsis"],"prefix":"10.3389","volume":"10","author":[{"given":"Marc","family":"Doman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Thy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Dessajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Dlela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Do Rego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwann","family":"Cariou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ejzenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Bouadma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"de Montmollin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1097\/CCM.0b013e318169eda9","article-title":"Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America","volume":"36","author":"O\u2019Grady","year":"2008","journal-title":"Crit Care Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"ofab161","DOI":"10.1093\/ofid\/ofab161","article-title":"Defining fever","volume":"8","author":"Mackowiak","year":"2021","journal-title":"Open Forum Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1111\/j.1525-1497.2006.00566.x","article-title":"Brief report: incidence, etiology, risk factors, and outcome of hospital-acquired fever: a systematic, evidence-based review","volume":"21","author":"Kaul","year":"2006","journal-title":"J Gen Intern Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1001\/archinte.158.17.1870","article-title":"Concepts of fever","volume":"158","author":"Mackowiak","year":"1998","journal-title":"Arch Intern Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S2213-2600(18)30003-1","article-title":"Body temperature in sepsis: a hot topic","volume":"6","author":"Annane","year":"2018","journal-title":"Lancet Respir Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s13054-016-1375-5","article-title":"The pathophysiological basis and consequences of fever","volume":"20","author":"Walter","year":"2016","journal-title":"Crit Care Lond Engl"},{"key":"ref7","first-page":"1254","article-title":"Fever in sepsis","volume":"78","author":"Schortgen","year":"2012","journal-title":"Minerva Anestesiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s13054-016-1467-2","article-title":"Should we treat pyrexia? 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