{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:57:20Z","timestamp":1787169440883,"version":"build-2736575974"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"\n Aim<\/jats:title>\n To explore the relationship between physical activity levels and wound healing and recurrence in people with venous leg ulcers.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Questionnaires and medical records were used to collect data, with responses used to group participants into different physical activity groups. The differences in healing and recurrence outcomes of ulcers among different physical activity groups were compared using Chi-square, Kaplan Meier survival analysis, Cox proportional hazards regression analysis, and Kruskal-Wallis test. To measure the strength of the association between physical activity levels and patient outcomes, Spearman\u2019s Rho tests were used. We used descriptive analysis to examine how physical activity levels change over 24\u2009weeks.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants were classified into four distinct groups based on physical activity levels reported at baseline and week 12. The survival analysis showed higher physical activity level was associated with a shorter time to healing (log-rank test\u2009=\u200914.78,\n df<\/jats:italic>\n \u2009=\u20093;\n p<\/jats:italic>\n \u2009=\u20090.002). The persistently moderate-to-vigorous group had a 7.3-fold increased likelihood of healing compared to the persistently sedentary group. High levels of physical activity were also associated with a better quality of life score at baseline (\n \n \n \u03c1<\/mml:mi>\n <\/mml:math>\n <\/jats:inline-formula>\n = 0.41,\n p<\/jats:italic>\n \u2009&lt;\u20090.000), week 12 (\n \n \n \u03c1<\/mml:mi>\n <\/mml:math>\n <\/jats:inline-formula>\n = 0.36,\n p<\/jats:italic>\n \u2009&lt;\u20090.001), and week 24 (\n \n \n \u03c1<\/mml:mi>\n <\/mml:math>\n <\/jats:inline-formula>\n = 0.49,\n p<\/jats:italic>\n \u2009&lt;\u20090.000). Most participants (48.5%) reported low levels of physical activity, which remained low for the entire study period.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n An increased level of physical activity was linked to a shorter healing time and enhanced quality of life. Low levels of physical activity appeared common among people with venous leg ulcers.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmed.2023.1305594","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T23:32:23Z","timestamp":1703115143000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between physical activity levels and healing in people with venous leg ulcers: secondary analysis of prospective cohort data"],"prefix":"10.3389","volume":"10","author":[{"given":"Yunjing","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Osadnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha K.","family":"Brusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Sussman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Gleghorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina D.","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s41038-018-0119-y","article-title":"The venous ulcer continues to be a 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likelihood of delayed venous leg ulcer healing and recurrence: development and reliability testing of risk assessment tools","volume":"63","author":"Parker","year":"2017","journal-title":"Ostomy Wound Manage"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0140-6736(13)62368-5","article-title":"Clinical and cost-effectiveness of compression hosiery versus compression bandages in treatment of venous leg ulcers (venous leg ulcer study IV, VenUS IV): a randomised controlled trial","volume":"383","author":"Ashby","year":"2014","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1007\/s11136-019-02128-6","article-title":"Comparison of EQ-5D-5L and SPVU-5D for measuring quality of life in patients with venous leg ulcers in an Australian setting","volume":"28","author":"Cheng","year":"2019","journal-title":"Qual Life Res Int J Qual Life Asp Treat Care 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people with venous leg ulcers: a multicentre, prospective, cohort study","volume":"15","author":"Smith","year":"2018","journal-title":"Int Wound J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1111\/bjd.16089","article-title":"Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomized controlled feasibility trial","volume":"178","author":"Klonizakis","year":"2018","journal-title":"Br J Dermatol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/iwj.12571","article-title":"Evaluating the effectiveness of a self-management exercise intervention on wound healing, functional ability and health-related quality of life outcomes in adults with venous leg ulcers: a randomised controlled trial","volume":"14","author":"O'Brien","year":"2017","journal-title":"Int Wound J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/iwj.12610","article-title":"Correlation between 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with venous leg ulcers: a qualitative study","volume":"16","author":"Kesterton","year":"2019","journal-title":"Int Wound J"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jtv.2023.03.004","article-title":"Planning exercise interventions as an adjunct treatment in managing venous leg ulcers: a qualitative study of nurses' perspectives","volume":"32","author":"Qiu","year":"2023","journal-title":"J Tissue Viability"}],"container-title":["Frontiers in 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