{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:49:07Z","timestamp":1772459347537,"version":"3.50.1"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Nocardia species are gram-positive, acid-fast, saprophytic, aerobic bacilli, predominantly resulting in opportunistic infections in immunocompromised individuals. Here, we reported a case of Nocardia infection in a 27-year-old woman with normal immunocompetence, who presented as a solitary neoplasm in the left principal bronchus with a chief complaint of postural dyspnea. By electrotomy via bronchoscopy, the neoplasm was successfully removed, and it was further identified as <jats:italic>Nocardia farcinica<\/jats:italic> by metagenomic next-generation sequencing.<\/jats:p>","DOI":"10.3389\/fmed.2023.1337303","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:22:14Z","timestamp":1704860534000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nocardia farcinica infection presenting as a solitary bronchial neoplasm in an immunocompetent adult: a case report"],"prefix":"10.3389","volume":"10","author":[{"given":"Yuying","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.mayocp.2011.11.016","article-title":"Nocardiosis: updates and clinical overview","volume":"87","author":"Wilson","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1128\/CMR.19.2.259-282.2006","article-title":"Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy","volume":"19","author":"Brown-Elliott","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.resinv.2022.11.004","article-title":"Clinical characteristics, outcomes, and factors associated with mortality in Nocardia pneumonia: 18 years' real-world data from a tertiary care hospital in Karachi","volume":"61","author":"Rahim","year":"2023","journal-title":"Pak Respir Invest"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1038\/s41587-021-01049-5","article-title":"Performance assessment of DNA sequencing platforms in the ABRF next-generation sequencing study","volume":"39","author":"Foox","year":"2021","journal-title":"Nat Biotechnol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s13258-021-01096-x","article-title":"Comparison between MGI and Illumina sequencing platforms for whole genome sequencing","volume":"43","author":"Jeon","year":"2021","journal-title":"Genes Genom"},{"key":"ref6","first-page":"2637","article-title":"Nocardia species","author":"Lerner","year":"1999","journal-title":"Principles and Practice of Infectious Diseases, Vol 2, 5th Ed. Eds. Mandell GL, Douglas RG, Bennett JE (New York, NY: Churchill Livingstone"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"246","DOI":"10.2169\/internalmedicine.40.246","article-title":"Pulmonary nocardiosis associated with idiopathic thrombocytopenic purpura","volume":"40","author":"Ando","year":"2001","journal-title":"Intern Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"390","DOI":"10.4103\/0255-0857.71831","article-title":"A fatal case of empyema thoracis by Nocardia farcinica in an immunocompromised patient","volume":"28","author":"Parande","year":"2010","journal-title":"Indian J Med Microbiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1155\/2009\/181750","article-title":"Nocardia farcinica lung abscess presenting in the context of advanced HIV infection: spontaneous resolution in response to highlyactive antiretroviral therapy alone","volume":"20","author":"King","year":"2009","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1093\/jac\/dkad236","article-title":"Phenotypic and genotypic analysis of antimicrobial resistance in Nocardia species","volume":"78","author":"Hershko","year":"2023","journal-title":"J Antimicrob Chemother"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e0156021","DOI":"10.1128\/spectrum.01560-21","article-title":"Epidemiology and antimicrobial resistance profiles of the Nocardia species in China, 2009 to 2021","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol Spectr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/MCP.0b013e3282f85dd3","article-title":"Pulmonary nocardiosis: risk factors, clinical features, diagnosis and prognosis","volume":"14","author":"Mart\u00ednez","year":"2008","journal-title":"Curr Opin Pulm Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/PEC.0b013e3181d1e3f7","article-title":"Infection caused by Nocardia farcinica mimicking pulmonary metastasis in an adolescent girl","volume":"26","author":"Babayigit","year":"2010","journal-title":"Pediatr Emerg Care"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4046\/trd.2016.79.2.101","article-title":"A case of Nocardia farcinica pneumonia and Mediastinitis in an immunocompetent patient","volume":"79","author":"Kim","year":"2016","journal-title":"Tuberc Respir Dis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.4103\/JOC.JOC_208_20","article-title":"Disseminated infection of Nocardia farcinica in an immunocompetent adult: mistaken for tuberculosis Bacilli in acid-fast staining of Bronchoalveolar lavage fluid","volume":"38","author":"Bai","year":"2021","journal-title":"J Cytol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"117954842211463","DOI":"10.1177\/11795484221146370","article-title":"Nocardia farcinica pneumonia with Sepsis and a bronchial neoplasm in a healthy patient: a case report","volume":"17","author":"Dong","year":"2023","journal-title":"Clin Med Insights Circ Respir Pulmon Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e304","DOI":"10.7759\/cureus","article-title":"Human Nocardia infections: a review of pulmonary nocardiosis","volume":"7","author":"Kandi","year":"2015","journal-title":"Cureus"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1159\/000508717","article-title":"Nocardiosis: a neglected disease","volume":"29","author":"Duggal","year":"2020","journal-title":"Med Princ Pract"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1146\/annurev-pathmechdis-012418-012751","article-title":"Clinical metagenomic next-generation sequencing for pathogen detection","volume":"14","author":"Gu","year":"2019","journal-title":"Annu Rev Pathol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"768613","DOI":"10.3389\/fcimb.2021.768613","article-title":"Detection of Nocardia by 16S ribosomal RNA gene PCR and metagenomic next-generation sequencing (mNGS)","volume":"11","author":"Ding","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e01758","DOI":"10.1016\/j.idcr.2023.e01758","article-title":"Clinical characteristics and treatment strategy of nocardiosis in lung transplant recipients: a single-center experience","volume":"32","author":"Xu","year":"2023","journal-title":"IDCases"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1186\/s12879-023-08615-z","article-title":"Clinical characteristics of hospitalized patients with Nocardia genus detection by metagenomic next generation sequencing in a tertiary hospital from southern China","volume":"23","author":"Liang","year":"2023","journal-title":"BMC Infect Dis"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"S231","DOI":"10.1093\/cid\/ciy693","article-title":"Microbiological diagnostic performance of metagenomic next-generation sequencing when applied to clinical practice","volume":"67","author":"Miao","year":"2018","journal-title":"Clin Infect Dis"},{"key":"ref24","author":"Melia","year":"2017"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1183\/09031936.97.10071542","article-title":"Pulmonary infection with Nocardia species: a report of 10 cases and review","volume":"10","author":"Men\u00e9ndez","year":"1997","journal-title":"Eur Respir J"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1337303\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:22:16Z","timestamp":1704860536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1337303\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":25,"alternative-id":["10.3389\/fmed.2023.1337303"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1337303","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"article-number":"1337303"}}