{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:06:16Z","timestamp":1753891576871,"version":"3.41.2"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Eosinophilic cholangitis (EC) is an uncommon form of benign biliary obstruction. It frequently eludes accurate clinical diagnosis, leading to inappropriate treatment methods. It is our aspiration that this clinical report will impart comprehensive insights into EC and, specifically, the critical role of tomographic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>A 34-year-old man was urgently admitted to the hospital due to excruciating abdominal distress persisting for several hours. Following a six-day course of anti-inflammatory therapy, his symptoms displayed marginal improvement, prompting his discharge. He returned to the hospital a month later for re-examination on doctor\u2019s orders. Based on the results of the re-examination, the patient refused steroid hormone shock therapy and subsequently underwent laparoscopic left-lateral hepatic lobectomy in order to confirm the diagnosis. The preoperative absolute counts of eosinophils in the peripheral blood were documented as 2.3\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, 3.06 \u00d7\u200910<jats:sup>9<\/jats:sup>\/L, and 1.50\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L consecutively; concurrently, the corresponding percentages of eosinophils were quantified at levels of 21.90%, 30.70%, and 19.20%. The subsequent postoperative pathological assessment unveiled EC as the definitive diagnosis. The patient has since remained free from disease recurrence and is presently alive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When encountering a patient presenting with persistent elevation in absolute eosinophil count in peripheral blood, coupled with imaging manifestations suggestive of intrahepatic periductal inflammation, diagnosis of EC should be highly suspected. The most optimal diagnostic and therapeutic workflow for EC could entail CT-guided liver lesion biopsy, ensued by glucocorticoid pulse therapy, and finally, short-term monitoring utilizing CT or MRI (including T1WI, T2WI, DWI, CEMRI) techniques.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1340667","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T04:17:58Z","timestamp":1705465078000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Rare benign obstructive disease of the biliary tract\u2014a rare case of eosinophilic cholangitis"],"prefix":"10.3389","volume":"10","author":[{"given":"Xiao-Ning","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Min","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Feng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.gie.2020.12.032","article-title":"ASGE guideline on the management of cholangitis","volume":"94","author":"Buxbaum","year":"2021","journal-title":"Gastrointest Endosc"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"906496","DOI":"10.1155\/2010\/906496","article-title":"Eosinophilic cholangitis and cholangiopathy: a sheep in wolves clothing","volume":"2010","author":"Nashed","year":"2010","journal-title":"HPB Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4065\/80.1.75","article-title":"Blood eosinophilia: a new paradigm in disease classification, diagnosis, and treatment","volume":"80","author":"Tefferi","year":"2005","journal-title":"Mayo Clin Proc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.7326\/0003-4819-97-1-78","article-title":"The idiopathic hypereosinophilic syndrome: clinical, pathophysiologic and therapeutic considerations","volume":"97","author":"Fauci","year":"1982","journal-title":"Ann Intern Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"589","DOI":"10.4253\/wjge.v11.i12.589","article-title":"Eosinophilic cholangitis: a case report of diagnostically challenging eosinophilic infiltrative biliary obstruction","volume":"11","author":"Dodda","year":"2019","journal-title":"World J Gastrointest Endosc"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1002\/jhbp.862","article-title":"A case with eosinophilic cholangitis which presented the unique cholangioscopic findings","volume":"28","author":"Hirata","year":"2021","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.lrr.2018.04.001","article-title":"A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia","volume":"9","author":"Hofmans","year":"2018","journal-title":"Leuk Res Rep"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.3748\/wjg.v13.i13.1995","article-title":"A case of eosinophilic cholangitis: imaging findings of contrast-enhanced ultrasonography, cholangioscopy, and intraductal ultrasonography","volume":"13","author":"Matsumoto","year":"2007","journal-title":"World J Gastroenterol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/jgh3.12454","article-title":"A case of juvenile eosinophilic cholangitis: rapid peripheral blood hypereosinophilia after admission leading to diagnosis","volume":"5","author":"Fukatsu","year":"2020","journal-title":"JGH Open"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/ajh.26352","article-title":"World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management","volume":"97","author":"Shomali","year":"2022","journal-title":"Am J Hematol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"000","DOI":"10.14218\/JCTH.2022.00347","article-title":"Guidelines on the diagnosis and Management of Primary Biliary Cholangitis (2021)","author":"You","year":"2023","journal-title":"J Clin Transl Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jhep.2017.03.022","article-title":"Electronic address: easloffice@easloffice.eu; European Association for the Study of the liver. EASL clinical practice guidelines: the diagnosis and management of patients with primary biliary cholangitis","volume":"67","year":"2017","journal-title":"J Hepatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1111\/joa.13808","article-title":"Association between anatomic variations of extrahepatic and intrahepatic bile ducts: do look up!","volume":"242","author":"Renzulli","year":"2023","journal-title":"J Anat"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.hpb.2021.02.014","article-title":"Percutaneous management of postoperative bile leak after hepato-pancreato-biliary surgery: a multi-center experience","volume":"23","author":"Mosconi","year":"2021","journal-title":"HPB"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1340667\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T04:18:01Z","timestamp":1705465081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1340667\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":14,"alternative-id":["10.3389\/fmed.2023.1340667"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1340667","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2024,1,17]]},"article-number":"1340667"}}