{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:55:55Z","timestamp":1793228155670,"version":"4.5.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Preeclampsia (PE), a pregnancy specific syndrome, is defined as new-onset hypertension (\u2265140\/90\u2009mmHg) and proteinuria diagnosed after gestational week 20 or new-onset pre-eclampsia associated signs in the absence of proteinuria, and it may tend to present as late as 4\u20136\u2009weeks\u2019 postpartum period. It is a leading cause of maternal mortality in both developed and developing countries. In order to prevent PE, the disease must be diagnosed at its earliest stage, however, the triads of high blood pressure, edema and albuminuria is neither specific nor sensitive enough for diagnosing the disease. Lactate dehydrogenase (LDH) is useful biochemical marker reflecting the occurrence of complications associated with preeclampsia. Besides, it has been suggested as potential biomarker to predict the severity of preeclampsia and as indicator of multi-organ involvement. The aim of this study was to investigate the diagnostic accuracy of LDH, which is affordable and easy to test, as a potential clinical biomarker to predict onset of preeclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A hospital based cross-sectional study was conducted as of September 9 to December 24, 2022 at Debre Birhan Comprehensive Specialized Hospital (DBCSH). A total of 132 study subjects (66 preeclamptic and 66 normotensive controls) were enrolled in the study. A receiver operating characteristics (ROC) curve was used to calculate the area under the curve (AUC) and determine diagnostic accuracy of LDH. Youden\u2019s index was used to identify an optimal cut-off point for LDH in detecting preeclampsia associated complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>AUC for LDH was found to be 0.963 (95% CI, 0.91, 1.0; <jats:italic>p<\/jats:italic>\u2009=\u20090.000) from ROC curve analysis. An optimal cut-off point for LDH was 376.5\u2009U\/L having a sensitivity and specificity of 87.5 and 90.8%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum LDH had an AUC of greater than 0.8 and showed good diagnostic accuracy in predicting development of preeclampsia. Disease duration, gestational age, systolic and diastolic blood pressure among enormous number of predictor variables had association with serum level of LDH.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1240848","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T05:02:11Z","timestamp":1715317331000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic performance of lactate dehydrogenase as a potential biomarker in predicting preeclampsia and associated factors"],"prefix":"10.3389","volume":"11","author":[{"given":"Awgichew Behaile","family":"Teklemariam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endeshaw Chekol","family":"Abebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melaku Mekonnen","family":"Agidew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atalo Agemas","family":"Ayenew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misganaw Asmamaw","family":"Mengistie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nega Dagnew","family":"Baye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelalem Tilahun","family":"Muche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"ref1","volume-title":"The differences between early-and late-onset pre-eclampsia preeclampsia: basic, genomic, and clinical","year":"2018"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1161\/01.HYP.0000054981.03589.E9","article-title":"Summary of the NHLBI working group on research on hypertension during pregnancy","volume":"41","author":"Roberts","year":"2003","journal-title":"Hypertension"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/1471-2458-13-138","article-title":"Pre-pregnancy predictors of hypertension in pregnancy among aboriginal and Torres Strait islander women in North Queensland, Australia; a prospective cohort study","volume":"13","author":"Campbell","year":"2013","journal-title":"BMC Public Health"},{"key":"ref4","first-page":"50","article-title":"Gamma Glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia","volume":"8","author":"Munde","year":"2014","journal-title":"Int J Med Health, Biomed Bioeng Pharmaceut Eng"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4108271","DOI":"10.1155\/2019\/4108271","article-title":"Early-and late-onset preeclampsia: a comprehensive cohort study of laboratory and clinical findings according to the new ISHHP criteria","volume":"2019","author":"Anna","year":"2019","journal-title":"Int J Hypertens"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1373\/clinchem.2016.254920","article-title":"Toward a better diagnosis for preeclampsia","volume":"62","author":"Young","year":"2016","journal-title":"Clin Chem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.18203\/2320-1770.ijrcog20193044","article-title":"Serum lactate dehydrogenase: a prognostic factor in pre-eclampsia","volume":"8","author":"Mehta","year":"2019","journal-title":"Int J Reproduct Contracept Obstetetr Gynecol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.5455\/2320-6012.ijrms20131110","article-title":"Evaluation of serum lactate dehydrogenase and gamma glutamyl transferase in preeclamptic pregnancy and its comparison with normal pregnancy in third trimester","volume":"1","author":"Sarkar","year":"2013","journal-title":"Int J Res Med Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"01","DOI":"10.9790\/0853-1601080104","article-title":"Maternal outcome in PIH patients in relation with serum LDH levels","volume":"16","author":"Sharma","year":"2017","journal-title":"IOSR Journal of Dental and Medical Sciences"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"571","DOI":"10.18231\/j.ijcbr.2019.118","article-title":"Can GGT and LDH be indicators of endothelial vascular damage in preeclampsia?","volume":"6","author":"Vanishree","year":"2019","journal-title":"Int J Clin Biochem Res"},{"key":"ref11","first-page":"4","article-title":"Role of serum lactate dehydrogenase as a biochemical prognostic marker for pre-eclampsia: a case control study in a tertiary Care Hospital in South India","volume":"6","author":"Garg","year":"2019","journal-title":"J Pregnancy Child Health"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3329\/jbsp.v10i2.27168","article-title":"Serum lactate dehydrogenase (LDH) level in severe preeclampsia","volume":"10","author":"Afroz","year":"2018","journal-title":"J Bangl Soc Physiol"},{"key":"ref13","first-page":"88","article-title":"Role of LDH (lactate dehydrogenase) in preeclampsia \u2013 eclampsia as a prognostic marker: an observational study","volume":"2","author":"Umasatyasri","year":"2015","journal-title":"Int Arch Integr Med"},{"key":"ref14","first-page":"1014","article-title":"Serum level of lactate dehydrogenase, Homocystein, hemoglobin and platelet in preeclampsia","volume":"27","author":"Borghei","year":"2011","journal-title":"Pakis J Med Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.12669\/pjms.344.14393","article-title":"Evaluation of serum biomarkers for detection of preeclampsia severity in pregnant women","volume":"34","author":"Kasraeian","year":"2018","journal-title":"Pak J Med Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s13224-011-0093-9","article-title":"Lactic dehydrogenase: a biochemical marker for preeclampsia \u2013 eclampsia","volume":"61","author":"Jaiswar","year":"2011","journal-title":"J Obstetr Gynecol India"},{"key":"ref17","first-page":"36","article-title":"Role of serum lactate dehydrogenase in preeclampsia in assessing the maternal and fetal outcome","volume":"3","author":"Munagavalasa","year":"2017","journal-title":"IOSR J Biotechnol Biochem"},{"key":"ref18","first-page":"17198","article-title":"Practice bulletin of the American college of obstetrics and gynaecologists 2019 on management of hypertensive disorders in pregnancy-a short review of the current recommendations","volume":"23","author":"Popovski","year":"2019","journal-title":"J Sci Tech Res"},{"key":"ref19","first-page":"313","article-title":"Evaluation of activities of serum gamma GLUTAMYL transferase and adenosine deaminase in pre-eclampsia-a CASE control study","volume":"6","author":"Patil","year":"2016","journal-title":"Nat J Med Res"},{"key":"ref20","first-page":"147","article-title":"Hypertensive disorders of pregnancy in Jimma university specialized hospital","volume":"21","author":"Wolde","year":"2011","journal-title":"Ethiop. J Health Sci"},{"key":"ref21","first-page":"5","article-title":"Hypertensive disorders of pregnancy: an ongoing holocoust","volume":"5","author":"Borade","year":"2014","journal-title":"Nat J Commun Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0100180","article-title":"The 2011 survey on hypertensive disorders of pregnancy (HDP) in China: prevalence, risk factors, complications pregnancy and perinatal outcomes","volume":"9","author":"Ye","year":"2014","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1007\/s40265-017-0823-0","article-title":"Aspirin for prevention of preeclampsia","volume":"77","author":"Atallah","year":"2017","journal-title":"Drugs"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.30699\/jogcr.7.6.497","article-title":"Evaluation of lactate dehydrogenase and gamma Glutamyl transferase among pregnant women with hypertensive disorders and their association with disease severity in Jimma medical center, Ethiopia","volume":"7","author":"Teklemariam","year":"2022","journal-title":"J Obstetr Gynecol Cancer Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.14260\/jemds\/2019\/600","article-title":"To study levels of LDH in Normal pregnancy, pre-eclampsia & eclampsia","volume":"8","author":"Kulkarni","year":"2019","journal-title":"J Evol Med Dent Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.18203\/2320-1770.ijrcog20183294","article-title":"Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women","volume":"7","author":"Ezzaldein","year":"2018","journal-title":"Int J Reproduct Contracept Obster Gynecol"},{"key":"ref27","first-page":"36","article-title":"Comparison of the level of uric acid and LDH in mothers in early and late preeclampsia and determination of its association with the severity of preeclampsia","author":"Shojaei","year":"2019","journal-title":"J Biochem Tech"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.preghy.2014.02.002","article-title":"How accurate are placental growth factor, urate, lactate dehydrogenase and proteinuria in diagnosing preeclampsia and its severity?","volume":"4","author":"Khalil","year":"2014","journal-title":"Preg Hypertens"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/7815214","article-title":"Alterations of several serum parameters are associated with preeclampsia and may be potential markers for the assessment of PE severity","volume":"2020","author":"Duan","year":"2020","journal-title":"Dis Markers"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1240848\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T05:02:20Z","timestamp":1715317340000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1240848\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,10]]},"references-count":29,"alternative-id":["10.3389\/fmed.2024.1240848"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1240848","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,10]]},"article-number":"1240848"}}