{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:28:50Z","timestamp":1758814130222,"version":"3.41.2"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to report the ocular manifestations in individuals with coronavirus disease 2019 (COVID-19) and investigate any correlation between the occurrence of ocular symptoms and systemic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective electronic survey was conducted among the general public in northern China from December 2022 through February 2023. Inclusion criteria for COVID-19 was confirmed testing positive via a polymerase chain reaction (PCR) test or testing positive for COVID-19 via an antigen kit. The anonymous survey collected information on demographics, systemic COVID-19 symptoms, ocular diagnosis and symptoms, comorbidities and disease history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,405 survey responses were collected and the final analysis included individuals in the 335 COVID-19 positive group and 434 individuals in the COVID-19 negative group. Among COVID-19 positive patients 66.3% (<jats:italic>n<\/jats:italic>\u202f=\u202f222) reported experiencing ocular symptoms. Dryness (<jats:italic>n<\/jats:italic>\u202f=\u202f106, 31.6%), blurred vision (<jats:italic>n<\/jats:italic>\u202f=\u202f81, 24.2%), eye pain (<jats:italic>n<\/jats:italic>\u202f=\u202f72, 21.5%), and itching (<jats:italic>n<\/jats:italic>\u202f=\u202f71, 21.2%) were the main features. COVID-19 was found to be associated with a higher prevalence of conjunctivitis, iritis, uveitis, retinal vein occlusion and optic neuritis. The majority of individuals (51.0%) developed eye symptoms after the onset of COVID-19 systemic symptoms. There was no significant association between the severity of systemic symptoms and ocular symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals with COVID-19 were significantly more likely to experience ocular symptoms. COVID-19 was found to be associated with a higher prevalence of retinal diseases. The majority of individuals developed ocular symptoms right after the onset of systemic symptoms.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1292821","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T15:57:48Z","timestamp":1736783868000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics of ocular findings of patients with coronavirus disease 2019 in China"],"prefix":"10.3389","volume":"11","author":[{"given":"Shudan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaoyang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"volume-title":"Features, 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