{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:30:10Z","timestamp":1777674610036,"version":"3.51.4"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Many patients with constipation also suffer from varying degrees of malnutrition, and the relationship between the two conditions is a vicious cycle. Surgery is the final step in the treatment of constipation, with a success rate of up to 95%. This study aims to investigate the effects of surgical treatment on the nutritional status of patients with chronic constipation and malnutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 60 patients with chronic constipation and various degrees of malnutrition who underwent surgery in our department from January 2020 to March 2023 were included in this study. Biochemical tests including BMI, albumin, total protein, hemoglobin, cholesterol and lymphocyte count were conducted, as well as measurements of inflammatory markers such as Interleukin-6 (IL-6), Interleukin-8 (IL-8), and C-reactive protein (CRP). Additionally, multiple nutritional risk screening scales (NRS2002, MUST, NRI, and MNA) and the prognostic nutritional index (PNI) were used to assess the nutritional status of patients before surgery, as well as at 1\u2009month, 3\u2009months, and 6\u2009months post-surgery. Finally, we analyzed the factors influencing postoperative recovery outcomes in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to pre-operation, the BMI of patients significantly increased at 1\u2009month, 3\u2009months, and 6\u2009months after the operation, with statistically significant differences (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). Multiple nutritional risk assessment tools (NRS2002, MUST, NRI, and MNA), as well as the prognostic nutritional index (NPI), indicated a reduction in nutritional risk and improvement in nutritional status at 1, 3, and 6\u2009months post-surgery, compared to pre-surgery levels (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). The levels of albumin, total protein, and hemoglobin in patients at 1, 3, and 6\u2009months after the surgery were significantly higher than those before the surgery (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). However, there was no significant change in the number of lymphocytes. Inflammatory markers such as IL-6, IL-8, and CRP exhibited a significant decrease after the surgery, reaching normal levels at 6\u2009months post-surgery (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). Low BMI, low PNI, and low cholesterol levels are independent risk factors for patient prognosis (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgical treatment can enhance the nutritional status of constipation patients with malnutrition, which in turn promotes the restoration of intestinal motility. The patient\u2019s nutritional status will impact the postoperative recovery outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1335203","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:32:13Z","timestamp":1725337933000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["To explore the postoperative nutritional status and factors influencing prognosis in patients with chronic constipation complicated by malnutrition"],"prefix":"10.3389","volume":"11","author":[{"given":"Le","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"ref1","first-page":"276","article-title":"Current status in surgical treatment of constipation","volume":"21","author":"Wang","year":"2018","journal-title":"Chin J Gastrointes Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1016\/j.mayocp.2019.01.031","article-title":"Chronic constipation","volume":"94","author":"Bharucha","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.bpg.2007.07.001","article-title":"Constipation","volume":"21","author":"Bharucha","year":"2007","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.3389\/fmed.2019.00019","article-title":"Gut microbiota and chronic constipation: a review and update","volume":"6","author":"Ohkusa","year":"2019","journal-title":"Front Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1096\/fj.14-259598","article-title":"Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells","volume":"29","author":"Reigstad","year":"2015","journal-title":"FASEB J"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.chom.2018.05.004","article-title":"Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion","volume":"23","author":"Bhattarai","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1053\/j.gastro.2020.09.030","article-title":"Sympathetic input to multiple cell types in mouse and human Colon produces region-specific responses","volume":"160","author":"Smith-Edwards","year":"2021","journal-title":"Gastroenterology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1053\/gast.2002.36600","article-title":"Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon","volume":"123","author":"Wedel","year":"2002","journal-title":"Gastroenterology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1136\/gut.51.4.496","article-title":"Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation","volume":"51","author":"Lyford","year":"2002","journal-title":"Gut"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/s41586-020-1975-8","article-title":"Neuronal programming by microbiota regulates intestinal physiology","volume":"578","author":"Obata","year":"2020","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"19375","DOI":"10.1038\/s41598-019-55937-7","article-title":"Rhubarb-evoke mucus secretion through aggregation and degranulation of mast cell in the Colon of rat: in vivo and ex vivo studies","volume":"9","author":"Wu","year":"2019","journal-title":"Sci Rep"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"G581","DOI":"10.1152\/ajpgi.00237.2016","article-title":"Ion channelopathies in functional GI disorders","volume":"311","author":"Beyder","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0889-8553(05)70168-0","article-title":"Slow transit constipation","volume":"30","author":"Bharucha","year":"2001","journal-title":"Gastroenterol Clin N Am"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"86","DOI":"10.5694\/mja18.00241","article-title":"Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management","volume":"209","author":"Black","year":"2018","journal-title":"Med J Aust"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/MCO.0000000000000238","article-title":"The ageing gastrointestinal tract","volume":"19","author":"Soenen","year":"2016","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"32128","DOI":"10.1242\/dmm.032128","article-title":"The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice","volume":"11","author":"Langhorst","year":"2018","journal-title":"Dis Model Mech"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s12603-016-0725-y","article-title":"Reduced intestinal motility, mucosal barrier function, and inflammation in aged monkeys[J]","volume":"21","author":"Mitchell","year":"2017","journal-title":"J Nutr Health Aging"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1802866","DOI":"10.1080\/19490976.2020.1802866","article-title":"Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health[J]","volume":"12","author":"Mukherjee","year":"2020","journal-title":"Gut Microbes"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev-immunol-070119-115104","article-title":"Interaction between the microbiota, epithelia, and immune cells in the intestine[J]","volume":"38","author":"Kayama","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.chom.2013.05.013","article-title":"A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice","volume":"13","author":"Hayashi","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1136\/gut.28.5.601","article-title":"Effect of changing transit time on colonic microbial metabolism in man","volume":"28","author":"Stephen","year":"1987","journal-title":"Gut"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1111\/j.1651-2227.1998.tb01547.x","article-title":"The intestinal ecosystem in chronic functional constipation","volume":"87","author":"Zoppi","year":"1998","journal-title":"Acta Paediatrica"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.15171\/mejdd.2017.78","article-title":"The association between modulating inflammatory cytokines and constipation of geriatrics in Iran","volume":"9","author":"Mokhtare","year":"2017","journal-title":"Middle East J Digestive Diseases"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e875","DOI":"10.1038\/s41581-024-00875-5","article-title":"Lymphocytes and innate immune cells in acute kidney injury and repair","volume":"24","author":"Lee","year":"2024","journal-title":"Nat Rev Nephrol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/s41577-021-00537-8","article-title":"CD8(+) T cell metabolism in infection and cancer","volume":"21","author":"Reina-Campos","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"ref26","first-page":"47","article-title":"Surgical treatment of constipation","volume":"49","author":"B\u0142achut","year":"1995","journal-title":"Rocz Akad Med Bialymst"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1111\/j.1600-6143.2012.04262.x","article-title":"Intestinal regeneration, residual function and immunological priming following rescue therapy after rat small bowel transplantation","volume":"12","author":"Pech","year":"2012","journal-title":"Am J Transplant Off J Am Soc Transplant Am Soc Transplant Surg"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1172\/JCI130176","article-title":"Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility","volume":"130","author":"Ye","year":"2020","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.surg.2020.11.004","article-title":"Beta-1 blocker reduces inflammation and preserves intestinal barrier function after open abdominal surgery","volume":"169","author":"Tan","year":"2021","journal-title":"Surgery"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1335203\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:32:17Z","timestamp":1725337937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1335203\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":29,"alternative-id":["10.3389\/fmed.2024.1335203"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1335203","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"article-number":"1335203"}}