{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:24:54Z","timestamp":1787793894690,"version":"build-2784847793"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is an uncommon, recurrent, inflammatory skin illness of the apocrine glands, with a questionable etiology. The disease is associated with a multitude of comorbidities, of which the appearance of malignancy is the most important. Squamous cell carcinoma is considered the most frequent malignancy that can appear in HS. A case report of a 72\u2009years-old male is presented, who suffered over 40\u2009years from persistent, extensive hidradenitis suppurativa in stage Hurley III, on the buttocks and perianal region, who recently presented two verrucous semi-consistent, skin-colored tumors on the right buttock. The biopsy and histopathological exam confirmed a verrucous type of squamous cell carcinoma. There are about 100 reported clinical cases of squamous cell carcinoma complicating hidradenitis suppurativa in the literature, but only a few describe a verrucous carcinoma as a clinical form. The particularity of the case is the rare appearance of multiple verrucous types of squamous cell carcinomas in a male patient, in Hurley Stage III, with a long HS disease duration, appearing on the perianal\/gluteal region, being the first case report in our country. We suggest that a tumor screening should be done for all the patients with HS who have these risks.<\/jats:p>","DOI":"10.3389\/fmed.2024.1336688","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T16:41:51Z","timestamp":1705077711000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Multiple verrucous squamous cell carcinomas developing on chronic hidradenitis suppurativa lesions\u2014a rare case report from Romania"],"prefix":"10.3389","volume":"11","author":[{"given":"Gyula L\u00e1szl\u00f3","family":"Fekete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Fekete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3 Barna","family":"Iantovics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia E.","family":"Fekete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilarie","family":"Brihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.4161\/derm.2.1.12490","article-title":"Comorbidities of hidradenitis suppurativa (acne inversa)","volume":"2","author":"Fimmel","year":"2010","journal-title":"Dermatoendocrinology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.12688\/f1000research.26083.1","article-title":"The most recent advances in understanding and managing hidradenitis suppurativa","volume":"9","author":"Narla","year":"2020","journal-title":"F1000Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.ijwd.2019.06.026","article-title":"Comorbidities of hidradenitis suppurativa: a review of the literature","volume":"5","author":"Cartron","year":"2019","journal-title":"Int J Womens Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1111\/j.1468-3083.2009.03356.x","article-title":"Hidradenitis suppurativa","volume":"23","author":"Revuz","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"350","DOI":"10.5114\/ada.2023.126563","article-title":"Hidradenitis suppurativa and squamous cell carcinoma: a systematic review of the literature","volume":"40","author":"Gierek","year":"2023","journal-title":"Postepy Dermatol Alergol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.15570\/actaapa.2018.5","article-title":"Cutaneous squamous cell carcinoma complicating hidradenitis suppurativa: a review of the prevalence, pathogenesis, and treatment of this dreaded complication","volume":"27","author":"Chapman","year":"2018","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1056\/NEJMcp1014163","article-title":"Clinical practice. 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