{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:54:10Z","timestamp":1789592050819,"version":"build-2803163510"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kimura disease is characterized by inflammation, with its underlying causes remaining uncertain. There is a lack of comprehensive and systematic research on the pathology of this condition in pediatric patients. Our objective is to study the clinical and pathological attributes of Kimura disease in pediatric patients and investigate the potential diagnostic significance of immunoglobulin E (IgE) in this context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and laboratory information, pathological characteristics, and follow-up data were correlated to examine the distinctive features. Immunohistochemistry, acid-fast staining, and molecular assay were used to identify the presence of IgE and pathogens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We conducted an analysis of five cases of Kimura disease in pediatric patients at our hospital. The patients\u2019 ages ranged from 5\u2009years and 7\u2009months to 14\u2009years and 2\u2009months, with 4 (80%) being male. The most common site was the head and neck region, particularly the postauricular subcutaneous area. Eosinophilia was observed in four patients (80%), and two patients (40%) had elevated serum immunoglobulin E (IgE) levels. Histopathological changes included eosinophilic infiltrates, follicular hyperplasia, and the proliferation of postcapillary venules. Immunohistochemical results supported the reactive nature of the lymphoid process and IgE deposition in the follicle, while no specific pathogens were discovered by special staining. All patients underwent surgical excision, and none experienced recurrence in their original location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Children with Kimura disease show distinct eosinophilic and IgE alterations in both laboratory findings and pathological features. The application of immunohistochemical staining of IgE could serve as a promising marker for diagnosing Kimura disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2024.1352206","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:30:07Z","timestamp":1714005007000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The clinical and pathological features of Kimura disease in pediatric patients"],"prefix":"10.3389","volume":"11","author":[{"given":"Lili","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2019ou","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"ref1","first-page":"179","article-title":"On 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unusual and challenging case simulating venous malformation on imaging studies-case report and review of literature","volume":"11","author":"Dokania","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1182\/blood.V82.5.1471.1471","article-title":"Relative contributions of human types 1 and 2 T-helper cell-derived eosinophilotrophic cytokines to development of eosinophilia","volume":"82","author":"Wierenga","year":"1993","journal-title":"Blood"},{"key":"ref13","first-page":"585","article-title":"Tuberculous lymphadenitis","volume":"57","author":"Mohapatra","year":"2009","journal-title":"J Assoc Physicians India"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1309\/JC8YM53L4E0L6PT5","article-title":"Cat-scratch disease: historic, clinical, and pathologic perspectives","volume":"121","author":"Lamps","year":"2004","journal-title":"Am J Clin 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Nephrol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"720144","DOI":"10.3389\/fmed.2021.720144","article-title":"Clinical, pathological, laboratory characteristics, and treatment regimens of Kimura disease and their relationships with tumor size and recurrence","volume":"8","author":"Fan","year":"2021","journal-title":"Front Med"}],"container-title":["Frontiers in 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