{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:17Z","timestamp":1753891217792,"version":"3.41.2"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Retroperitoneal fibrosis, a condition of uncertain origin, is rarely linked to 8% of malignant cases, including breast, lung, gastrointestinal, genitourinary, thyroid, and carcinoid. The mechanism leading to peritoneal fibrosis induced by tumors is not well understood, possibly encompassing direct infiltration of neoplastic cells or the initiation of inflammatory responses prompted by cytokines released by tumor cells. We report a case of breast cancer with renal metastasis and retroperitoneal fibrosis detected using <jats:sup>18<\/jats:sup>F-FDG PET\/CT, providing help for clinical diagnosis and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 49-year-old woman was referred to the hospital with elevated creatinine and oliguria for over a month. Abdominal computer tomography (CT) and magnetic resonance imaging (MRI) showed a retroperitoneal fibrosis-induced acute kidney injury (AKI) was suspected. However, a percutaneous biopsy of the kidney lesion confirmed metastasis from breast cancer. The physical examination revealed inverted nipples and an orange peel appearance on the skin of both breasts. Ultrasonography revealed bilateral hyperplasia (BIRADS 4a) of the mammary glands and bilateral neck and axillary lymphadenopathy. Subsequently, <jats:sup>18<\/jats:sup>F-deoxyglucose positron emission tomography\/computer tomography (<jats:sup>18<\/jats:sup>F-FDG PET\/CT) detected abnormally high uptake (SUVmax) in the bilateral mammary glands and axillary lymph nodes, suggesting bilateral breast cancer. Furthermore, abnormal <jats:sup>18<\/jats:sup>F-FDG uptake was detected in the kidney, suggesting renal metastasis. In addition, abnormal <jats:sup>18<\/jats:sup>F-FDG uptake was observed in the vertebrae, accompanied by an elevation in inhomogeneous bone mineral density, raising suspicion of bone metastases. However, the possibility of myelodysplasia cannot be dismissed, and further investigations will be conducted during close follow-ups. There was significant <jats:sup>18<\/jats:sup>F-FDG uptake in the retroperitoneal position indicating a potential association between retroperitoneal fibrosis and breast cancer. The final pathological diagnosis of the breast tissue confirmed bilateral invasive ductal carcinoma. The patient had been treated with 11\u2009cycles of albumin-bound (nab)-paclitaxel (0.3\u2009mg) and had no significant adverse reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this case, neither the bilateral breast cancer nor the kidney metastatic lesion showed typical nodules or masses, so breast ultrasound, abdominal CT, and MRI did not suggest malignant lesions. PET\/CT played an important role in detecting occult metastases and primary lesions, thereby contributing to more accurate staging, monitoring treatment responses, and prediction of prognosis in breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1353822","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T04:29:56Z","timestamp":1714364996000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Untypical bilateral breast cancer with peritoneal fibrosis on 18F-FDG PET\/CT: case report and literature review"],"prefix":"10.3389","volume":"11","author":[{"given":"Lele","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongkang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenpeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushuo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1089\/end.1996.10.535","article-title":"Laparoscopic diagnosis of malignant retroperitoneal fibrosis","volume":"10","author":"Kava","year":"1996","journal-title":"J Endourol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.pathol.2019.12.004","article-title":"Metastatic lobular carcinoma presenting as retroperitoneal fibrosis: a rare presentation detected using post-mortem cytology","volume":"52","author":"MacNeil","year":"2020","journal-title":"Pathology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.clinimag.2011.10.001","article-title":"Frequency and etiology of unexplained bilateral Hydronephrosis in patients with breast Cancer: results of a longitudinal Ct study","volume":"36","author":"Kane","year":"2012","journal-title":"Clin Imaging"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1080\/11024150152619408","article-title":"Metastatic retroperitoneal and mediastinal fibrosis as first sign of recurrence of breast cancer","volume":"167","author":"Gogas","year":"2001","journal-title":"Eur J Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e32031","DOI":"10.7759\/cureus.32031","article-title":"A case of follicular lymphoma mimicking idiopathic retroperitoneal fibrosis","volume":"14","author":"Lan","year":"2022","journal-title":"Cureus"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1177\/1078155214543279","article-title":"Retroperitoneal fibrosis due to B-cell non-Hodgkin lymphoma: responding to rituximab!","volume":"22","author":"Alvarez Argote","year":"2016","journal-title":"J Oncol Pharm Pract"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s13730-014-0164-8","article-title":"A case of acute kidney injury due to secondary retroperitoneal fibrosis caused by direct invasion of esophageal squamous cell carcinoma","volume":"4","author":"Mori","year":"2015","journal-title":"CEN Case Rep"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1159\/000521888","article-title":"Gastric signet-ring-cell adenocarcinoma with delayed retroperitoneal metastasis and fibrosis","volume":"15","author":"Benesch","year":"2022","journal-title":"Case Rep Oncol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.jtho.2015.10.023","article-title":"Retroperitoneal metastasis from lung adenocarcinoma mimics retroperitoneal fibrosis","volume":"11","author":"Nishiyama","year":"2016","journal-title":"J Thorac Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1200\/jco.2006.10.5056","article-title":"Incidence and prognosis of synchronous and Metachronous bilateral breast Cancer","volume":"25","author":"Hartman","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"S341","DOI":"10.4103\/jcrt.JCRT_1729_20","article-title":"Bilateral breast Cancer-its Clinicopathological profile and management: an experience from a tertiary care center from eastern India","volume":"18","author":"Mishra","year":"2022","journal-title":"J Cancer Res Ther"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10549-022-06532-4","article-title":"Synchronous and Metachronous bilateral breast Cancer among women with a history of lobular carcinoma in situ","volume":"194","author":"Mallory","year":"2022","journal-title":"Breast Cancer Res Treat"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.gyobfe.2003.01.002","article-title":"Bilateral breast Cancer. Incidence and risk factors","volume":"32","author":"El Hanchi","year":"2004","journal-title":"Gynecol Obstet Fertil"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s12885-018-4229-5","article-title":"Germline breast Cancer susceptibility gene mutations and breast Cancer outcomes","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Cancer"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/cancers10120524","article-title":"Brca mutations and breast","volume":"10","author":"Kotsopoulos","year":"2018","journal-title":"Cancer Prev"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e4975","DOI":"10.1097\/md.0000000000004975","article-title":"Effect of Brca germline mutations on breast Cancer prognosis: a systematic review and Meta-analysis","volume":"95","author":"Baretta","year":"2016","journal-title":"Medicine"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1200\/jco.2008.20.7019","article-title":"Pathologic complete response rates in young women with Brca1-positive breast cancers after neoadjuvant chemotherapy","volume":"28","author":"Byrski","year":"2010","journal-title":"J Clin Oncol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1093\/annonc\/mdt384","article-title":"Parp inhibitors for Brca1\/2 mutation-associated and Brca-like malignancies","volume":"25","author":"Lee","year":"2014","journal-title":"Ann Oncol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast Cancer for Brca1 and Brca2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1111\/tbj.13972","article-title":"Medical Management of Newly Diagnosed Breast Cancer in a Brca1\/2 mutation carrier","volume":"26","author":"Desai","year":"2020","journal-title":"Breast J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"15881","DOI":"10.1002\/cam4.6226","article-title":"A study of clinical and molecular characteristics in bilateral primary breast Cancer","volume":"12","author":"Li","year":"2023","journal-title":"Cancer Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/j.1524-4741.2010.00976.x","article-title":"Bilateral breast carcinoma: clinical characteristics and its impact on survival","volume":"16","author":"Vuoto","year":"2010","journal-title":"Breast J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/sj.bjc.6601042","article-title":"Epidemiologic and molecular risk factors for contralateral breast Cancer among young women","volume":"89","author":"Li","year":"2003","journal-title":"Br J Cancer"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"4763","DOI":"10.1200\/jco.2011.35.0165","article-title":"A case-match study comparing unilateral with synchronous bilateral breast Cancer outcomes","volume":"29","author":"Nichol","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/bjs.6553","article-title":"Prognosis of synchronous bilateral breast Cancer","volume":"96","author":"Irvine","year":"2009","journal-title":"Br J Surg"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10549-011-1491-5","article-title":"Multiple foci of invasive breast Cancer: can breast Mri influence surgical management?","volume":"128","author":"Johnson","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1102\/1470-7330.2010.9031","article-title":"PET\/CT and breast cancer","volume":"10","author":"Hegarty","year":"2010","journal-title":"Cancer Imaging"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1097\/00007611-198012000-00009","article-title":"Breast Cancer and retroperitoneal metastasis","volume":"73","author":"Carloss","year":"1980","journal-title":"South Med J"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"791","DOI":"10.4067\/s0034-98872014000600015","article-title":"Retroperitoneal fibrosis associated with malignancies: report of eight cases","volume":"142","author":"Vega","year":"2014","journal-title":"Rev Med Chile"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3949\/ccjm.69.2.160","article-title":"Idiopathic retroperitoneal fibrosis: prompt diagnosis preserves organ function","volume":"69","author":"Monev","year":"2002","journal-title":"Cleve Clin J Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e11842","DOI":"10.1097\/md.0000000000011842","article-title":"Mediastinal and retroperitoneal fibrosis as a manifestation of breast Cancer metastasis: a case report and literature review","volume":"97","author":"Kim","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"ref33","first-page":"15417","article-title":"Metastasis of breast cancer to renal cancer: report of a rare case","volume":"8","author":"Huo","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/1097-0142(1950)3:1<74::aid-cncr2820030111>3.0.co;2-7","article-title":"Metastases in carcinoma; analysis of 1000 autopsied cases","volume":"3","author":"Abrams","year":"1950","journal-title":"Cancer"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"101302","DOI":"10.1016\/j.eucr.2020.101302","article-title":"Breast Cancer metastatic to the kidney: case report","volume":"33","author":"Ahmed","year":"2020","journal-title":"Urol Case Rep"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"80","DOI":"10.12865\/chsj.46.01.11","article-title":"Metastases to the kidney: a case report and review of the literature","volume":"46","author":"Cazacu","year":"2020","journal-title":"Curr Health Sci J"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1111\/bju.13194","article-title":"Metastases to the kidney: a comprehensive analysis of 151 patients from a tertiary referral Centre","volume":"117","author":"Zhou","year":"2016","journal-title":"BJU Int"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/08998280.2015.11929235","article-title":"Carcinoma of the lungs causing enlarged kidneys","volume":"28","author":"Srisung","year":"2015","journal-title":"Proc (Baylor Univ Med Cent)"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1353822\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T04:30:02Z","timestamp":1714365002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1353822\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":38,"alternative-id":["10.3389\/fmed.2024.1353822"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1353822","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2024,4,29]]},"article-number":"1353822"}}