{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:05:03Z","timestamp":1753891503246,"version":"3.41.2"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Gynecomastia can be caused by neurofibromas but has rarely been reported. The present case report describes the clinical appearance, diagnosis, and therapy of a rare combination of a 14\u2009year-old adolescent male unilateral severe gynecomastia with NF-1 neurofibromatosis. In this particular case, we successfully performed minimally invasive surgery using endoscopic mastectomy, which not only resulted in a satisfactory appearance but also confirmed the presence of neurofibroma type 1 by detecting typical immunohistochemical indicators associated with the disease. Additionally, we analyzed the gene responsible for the disease, c.1431del: p. F477Lfs*21, based on the patient\u2019s family history.<\/jats:p>","DOI":"10.3389\/fmed.2024.1364089","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T04:33:30Z","timestamp":1719808410000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral severe gynecomastia in a 14\u2009year-old adolescent with neurofibromatosis type 1 undergoing endoscopic mastectomy: a case report"],"prefix":"10.3389","volume":"11","author":[{"given":"Fangjian","family":"Shang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duojun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengren","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.ijscr.2014.11.040","article-title":"Clinical and surgical management of unilateral prepubertal gynecomastia","volume":"5","author":"Ferraro","year":"2014","journal-title":"Int J Surg Case Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1186\/1752-1947-8-440","article-title":"Breast ultrasound in the management of gynecomastia in Peutz-Jeghers syndrome in monozygotic twins: two case reports","volume":"8","author":"Di Grezia","year":"2014","journal-title":"J Med Case Rep"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1007\/s00266-013-0188-z","article-title":"Management of Prepubertal Gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: from aromatase inhibitors to subcutaneous mastectomy","volume":"37","author":"Ferraro","year":"2013","journal-title":"Aesth Plast Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"5850","DOI":"10.3390\/ijms22115850","article-title":"Current understanding of neurofibromatosis type 1, 2, and schwannomatosis","volume":"22","author":"Tamura","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3238\/arztebl.2020.0354","article-title":"The neurofibromatoses","volume":"117","author":"Farschtschi","year":"2020","journal-title":"Deutsches Arzteblatt International"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.hoc.2021.08.010","article-title":"Neurofibromatoses","volume":"36","author":"Jordan","year":"2022","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.surg.2023.04.022","article-title":"The combination of endoscopic subcutaneous mastectomy and liposuction (Liu and Shang's 2-hole 7-step method) as the treatment of gynecomastia","volume":"174","author":"Shang","year":"2023","journal-title":"Surgery"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S0899-7071(04)00004-X","article-title":"Neurofibroma of the breast in a boy with neurofibromatosis type 1","volume":"28","author":"Murat","year":"2004","journal-title":"Clin Imaging"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s004280100399","article-title":"Gynecomastia in type-1 neurofibromatosis with features of pseudoangiomatous stromal hyperplasia with giant cells. Report of two cases","volume":"438","author":"Damiani","year":"2001","journal-title":"Virchows Arch"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.prp.2012.03.003","article-title":"Unilateral gynecomastia and pseudoangiomatous stromal hyperplasia in neurofibromatosis: case report and review of the literature","volume":"208","author":"Kimura","year":"2012","journal-title":"Pathol. Res. Practice"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00428-002-0656-3","article-title":"Gynecomastia with pseudoangiomatous stromal hyperplasia and multinucleated giant cells. Association with neurofibromatosis type 1","volume":"441","author":"Zamecnik","year":"2002","journal-title":"Virchows Archi"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1136\/jmg.33.1.2","article-title":"Molecular genetics of neurofibromatosis type 1 (NF1)","volume":"33","author":"Shen","year":"1996","journal-title":"J Med Genet"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1364089\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T04:33:33Z","timestamp":1719808413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1364089\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":12,"alternative-id":["10.3389\/fmed.2024.1364089"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1364089","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2024,7,1]]},"article-number":"1364089"}}