{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:31:45Z","timestamp":1768905105977,"version":"3.49.0"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>In dermatology, a keloid is one of the most common skin morphological abnormalities caused by excessive proliferation of fibroblasts. Keloids that are large or occur near important joint sites often cause varying degrees of physiological dysfunction in patients, therefore requiring medical treatment. A boy with congenital syndactyly developed huge keloids at the surgical site after undergoing surgical correction treatment. After treatment using trepanation combined with superficial radiotherapy (SRT-100) in our hospital, most of the boy\u2019s keloids shrank and flattened. The affected foot returned to its normal appearance, and the boy could wear shoes normally. The boy did not complain of pain, numbness, or any other distinctive discomfort after completing the treatment. This suggested that the combination of trepanation and SRT-100 may be one of the options for treating hypertrophic keloids that cannot be treated by surgical excision.<\/jats:p>","DOI":"10.3389\/fmed.2024.1369953","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T14:46:15Z","timestamp":1716907575000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful treatment of Giant keloid on the right toes using trepanation combined with superficial radiotherapy (SRT-100): a case report with literature review"],"prefix":"10.3389","volume":"11","author":[{"given":"Ying-hua","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-min","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-lu","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1097\/00006534-199910000-00031","article-title":"On the nature of hypertrophic scars and keloids: a review","volume":"104","author":"Niessen","year":"1999","journal-title":"Plast Reconstr Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00403-006-0651-7","article-title":"Quality of life of patients with keloid and hypertrophic scarring","volume":"297","author":"Bock","year":"2006","journal-title":"Arch Dermatol Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"300060519891664","DOI":"10.1177\/0300060519891664","article-title":"Spontaneous symmetrical giant keloids at the bilateral labia majora: a case report","volume":"48","author":"Zhang","year":"2020","journal-title":"J Int Med Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0007-1226(65)80062-5","article-title":"Early post-operative irradiation in the treatment of keloid scars","volume":"18","author":"Craig","year":"1965","journal-title":"Br J Plast Surg"},{"key":"ref5","first-page":"104","article-title":"Radiotherapy treatment of keloids in Ibadan","volume":"6","author":"Abdus","year":"2016","journal-title":"J Te West African College of Surgeons"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3109\/02841869509127180","article-title":"Cancer incidence after radiotherapy for skin Haemangioma during infancy","volume":"34","author":"Lindberg","year":"1995","journal-title":"Acta Oncol"},{"key":"ref7","first-page":"4223","article-title":"Sensitization of keloid fibroblasts by quercetin through the PI3K\/Akt pathway is dependent on regulation of HIF-1\u03b1","volume":"10","author":"Si","year":"2018","journal-title":"Am J Transl Res"},{"key":"ref8","article-title":"Soheil S","author":"Mohammadi","year":"","journal-title":"Manag Ear Keloids Using Surg Excision Comb"},{"key":"ref9","first-page":"187","article-title":"Response of keloid fibroblasts to vitamin D3 and quercetin treatment - 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