{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:05:10Z","timestamp":1753891510432,"version":"3.41.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Idiopathic nodular glomerulosclerosis (ING) is a rare condition characterized by poor renal prognosis. The pathophysiology remains incompletely understood. Histologically, it closely resembles diabetic nephropathy. The development of this disease seems to be influenced by factors such as metabolic syndrome, particularly hypertension and glucose intolerance, along with active smoking. We report a case of ING in an obese 71-year-old male patient who had a long history of untreated hypertension and smoking. The patient underwent conservative treatment involving the administration of an angiotensin-2 receptor antagonist and dapagliflozin, resulting in favorable disease progression. Additional therapeutic measures, such as discontinuation of smoking and efforts toward weight loss, are strongly advised. Furthermore, regular screening for diabetes in the follow-up is crucial, as it can play a pathophysiological role in the disease and may manifest at a later stage, as observed in our clinical case.<\/jats:p>","DOI":"10.3389\/fmed.2024.1379547","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T04:29:33Z","timestamp":1716179373000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Idiopathic nodular glomerulosclerosis: a case report"],"prefix":"10.3389","volume":"11","author":[{"given":"Claudia","family":"Landry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rodriguez-Calero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Bocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"B1","first-page":"68","article-title":"Idiopathic lobular glomerulonephritis (nodular mesangial sclerosis): A distinct diagnostic entity.","volume":"32","author":"Alpers","year":"1989","journal-title":"Clin Nephrol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1016\/j.humpath.2008.05.004","article-title":"Idiopathic nodular glomerulosclerosis: A clinicopathologic study of 15 cases.","volume":"39","author":"Li","year":"2008","journal-title":"Hum Pathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1053\/hupa.2002.126189","article-title":"Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity linked to hypertension and smoking.","volume":"33","author":"Markowitz","year":"2002","journal-title":"Hum Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1093\/ndt\/gfaa331","article-title":"Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans.","volume":"37","author":"Eadon","year":"2021","journal-title":"Nephrol Dial Transplant."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1093\/ndt\/gfl422","article-title":"Idiopathic nodular glomerulosclerosis in a non-diabetic hypertensive smoker\u2013case report and review of literature.","volume":"21","author":"Sarat","year":"2006","journal-title":"Nephrol Dial Transplant."},{"key":"B6","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.mehy.2018.09.036","article-title":"Impaired glucose metabolism \u2013 A potential risk factor for idiopathic nodular glomerulosclerosis: A single center study.","volume":"121","author":"Hamrahian","year":"2018","journal-title":"Med Hypoth."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.01.222","article-title":"217 Is it idiopathic nodular glomerulosclerosis or diabetic glomerulosclerosis?","volume":"79","author":"Akther","year":"2022","journal-title":"Am J Kidney Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/joim.12803","article-title":"Inflammation of brown\/beige adipose tissues in obesity and metabolic disease.","volume":"284","author":"Villarroya","year":"2018","journal-title":"J Intern Med."},{"key":"B9","first-page":"5","article-title":"KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease (CKD).","volume":"3","year":"2013","journal-title":"Kidney Int Suppl."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1379547\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T04:29:35Z","timestamp":1716179375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1379547\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":9,"alternative-id":["10.3389\/fmed.2024.1379547"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1379547","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"article-number":"1379547"}}