{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:14:27Z","timestamp":1771658067552,"version":"3.50.1"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Toxic epidermal necrolysis (TEN) is a rare but serious immune-mediated life-threatening skin and mucous membrane reaction that is mainly caused by drugs, infections, vaccines, and malignant tumors. A 74-year-old woman presented with a moderate fever of unknown cause, which was relieved after 2\u2009days, but with weakness and decreased appetite. Red maculopapules appeared successively on the neck, trunk, and limbs, expanding gradually, forming herpes and fusion, containing a yellow turbidous liquid and rupturing to reveal a bright red erosive surface spreading around the eyes and mouth. The affected body surface area was &amp;gt;90%. The severity of illness score for toxic epidermal necrolysis was 2 points. The drug eruption area and severity index score was 77. She was diagnosed with TEN caused by hepatitis A virus and treated with 160\u2009mg\/day methylprednisolone, 300\u2009mg\/day cyclosporine, and 20\u2009g\/day gammaglobulin. Her skin showed improvements after 3\u2009days of treatment and returned to nearly normal after 1\u2009month, and liver function was completely normal after 2\u2009months.<\/jats:p>","DOI":"10.3389\/fmed.2024.1395236","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T04:26:17Z","timestamp":1717561577000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Toxic epidermal necrolysis caused by viral hepatitis A: a case report and literature review"],"prefix":"10.3389","volume":"11","author":[{"given":"Yun","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Wen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1001\/archdermatol.2007.48","article-title":"Toxic epidermal necrolysis due to zonisamide associated with reactivation of human herpesvirus 6","volume":"144","author":"Teraki","year":"2008","journal-title":"Arch Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/all.12410","article-title":"The dynamics of herpesvirus reactivations during and after severe drug eruptions: their relation to the clinical phenotype and therapeutic outcome","volume":"69","author":"Ishida","year":"2014","journal-title":"Allergy"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"457161","DOI":"10.1155\/2013\/457161","article-title":"Mycoplasma pneumoniae with atypical Stevens-Johnson syndrome: a diagnostic challenge","volume":"2013","author":"Yachoui","year":"2013","journal-title":"Case Rep Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e21825","DOI":"10.7759\/cureus.21825","article-title":"Atypical Stevens-Johnson syndrome associated with Mycoplasma pneumoniae","volume":"14","author":"Beheshti","year":"2022","journal-title":"Cureus"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"25284","DOI":"10.51894\/001c.25284","article-title":"Mycoplasma pneumoniae-induced rash and mucositis: a systematic review of the literature","volume":"6","author":"Lofgren","year":"2021","journal-title":"Spartan Med Res J"},{"key":"ref6","first-page":"V10210804","article-title":"COVID-19 induced Stevens-Johnson syndrome","volume":"184","author":"Pagh","year":"2022","journal-title":"Ugeskr Laeger"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e23562","DOI":"10.7759\/cureus.23562","article-title":"COVID-19: a curious abettor in the occurrence of Stevens-Johnson syndrome","volume":"14","author":"Grover","year":"2022","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1046\/j.1523-1747.2000.00061.x","article-title":"SCORTEN: a severity-of-illness score for toxic epidermal necrolysis","volume":"115","author":"Bastuji-Garin","year":"2000","journal-title":"J Invest Dermatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"187 e1-16","DOI":"10.1016\/j.jaad.2013.05.002","article-title":"Toxic epidermal necrolysis: part II. 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