{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:40:01Z","timestamp":1769272801857,"version":"3.49.0"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>This study aimed to investigate the dose\u2013response relationship of rocuronium administered based on skeletal muscle weight and to assess the feasibility of calculating rocuronium dosage by skeletal muscle weight in short surgeries for patients with obesity. This single-center, randomized controlled clinical trial included 71 patients with obesity aged 28\u201370\u2009years, with body fat percentages (PBF) &amp;gt;20% in men and\u2009&amp;gt;\u200928% in women, ASA status I-III, scheduled for tracheoscopy. Patients were randomly allocated into two groups: skeletal muscle group (SM group) received rocuronium based on the skeletal muscle content (1.0\u2009mg\/kg, <jats:italic>n<\/jats:italic>\u2009=\u200931), and the conventional administration group (conventional group) received rocuronium based on total body weight (0.45\u2009mg\/kg, <jats:italic>n<\/jats:italic>\u2009=\u200930). General anesthesia was administered using the same protocol. Parameters recorded included patients\u2019 general condition, muscle relaxant usage, onset time of muscle relaxants, non-response time, clinical effect time, 75% recovery time, and recovery index. Additionally, occurrences of body movement, choking, and incomplete muscle relaxation during surgery were recorded. Compared to the conventional group, the SM group required significantly less rocuronium dosage, resulting in significantly lower non-response time, clinical effect time, 75% recovery time, and recovery index (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05), and the onset time is slightly longer. Neither group experienced body movement, choking, or incomplete muscle relaxation (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05). Utilizing skeletal muscle weight to calculate rocuronium dosage in short surgeries for patients with obesity can reduce dosage, shorten recovery time, and prevent residual muscle relaxation while achieving satisfactory muscle relaxation to meet surgical requirements.<\/jats:p>","DOI":"10.3389\/fmed.2024.1399475","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T12:20:05Z","timestamp":1717071605000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility of calculating rocuronium dosage by skeletal muscle weight in patients with obesity"],"prefix":"10.3389","volume":"11","author":[{"given":"Zhenhua","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benmu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengqun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"E1157","DOI":"10.1152\/ajpendo.00351.2011","article-title":"Update on adipose tissue blood flow regulation","volume":"302","author":"Sotornik","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"306","DOI":"10.4103\/sja.sja_185_22","article-title":"Physiologic and pharmacologic considerations in morbid obesity and bariatric anesthesia","volume":"16","author":"Brondeel","year":"2022","journal-title":"Saudi J Anaesth"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"862632","DOI":"10.3389\/fsurg.2022.862632","article-title":"Postoperative recovery outcomes for obese patients undergoing general anesthesia: a meta-analysis of randomized controlled trials","volume":"9","author":"Hu","year":"2022","journal-title":"Front Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"332","DOI":"10.4103\/sja.sja_235_22","article-title":"The patient with obesity and super-super obesity: perioperative anesthetic considerations","volume":"16","author":"Kaye","year":"2022","journal-title":"Saudi J Anaesth"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1213\/ane.0b013e3181f6d9c0","article-title":"Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects","volume":"113","author":"Ingrande","year":"2011","journal-title":"Anesth Anal"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/osp4.321","article-title":"Evaluation of multi-frequency bioelectrical impedance analysis for the assessment of body composition in individuals with obesity","volume":"5","author":"Sullivan","year":"2018","journal-title":"Obes Sci Pract"},{"key":"ref7","volume-title":"Nutritional assessment","author":"Lee","year":"1996"},{"key":"ref8","volume-title":"Contemporary diagnosis and management of obesity","author":"Bray","year":"1998"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"101086","DOI":"10.1016\/j.accpm.2022.101086","article-title":"Influence of the amount of skeletal muscle mass on rocuronium-induced neuromuscular block","volume":"41","author":"Doo","year":"2022","journal-title":"Anaesth Crit Care Pain Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1124\/dmd.116.071605","article-title":"Morbid obesity alters both pharmacokinetics and pharmacodynamics of propofol: dosing recommendation for anesthesia induction","volume":"44","author":"Dong","year":"2016","journal-title":"Drug Metab Dispos"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1097\/00000542-199809000-00004","article-title":"Remifentanil pharmacokinetics in obese versus lean patients","volume":"89","author":"Egan","year":"1998","journal-title":"Anesthesiology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s12630-017-0852-x","article-title":"Posologie optimale de propofol pour l\u2019induction des patients ob\u00e8ses morbides: Une \u00e9tude randomis\u00e9e contr\u00f4l\u00e9e comparant l\u2019indice bispectral et une \u00e9chelle de poids id\u00e9al","volume":"64","author":"Subramani","year":"2017","journal-title":"Can J Anesth"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1213\/ane.0000000000000317","article-title":"Performance of propofol target-controlled infusion models in the obese","volume":"119","author":"Cort\u00ednez","year":"2014","journal-title":"Anesth Anal"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.15537\/smj.2016.1.14099","article-title":"Comparison of the effect of rocuronium dosing based on corrected or lean body weight on rapid sequence induction and neuromuscular blockade duration in obese female patients","volume":"37","author":"Sak\u0131zc\u0131-Uyar","year":"2016","journal-title":"Saudi Med J"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1213\/01.ane.0000132781.62934.37","article-title":"The effects of Cisatracurium on morbidly obese women","volume":"99","author":"Leykin","year":"2004","journal-title":"Anesth Anal"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.redar.2019.03.005","article-title":"Bloqueo neuromuscular residual en pacientes vulnerables: complicaciones pulmonares postoperatorias a causa de obesidad y apnea Obstructiva del Sue\u00f1o","volume":"66","author":"Brull","year":"2019","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1365-2125.2010.03803.x","article-title":"Comparative evaluation of atracurium dosed on ideal body weight vs. total body weight in morbidly obese patients","volume":"71","author":"Van Kralingen","year":"2010","journal-title":"Br J Clin Pharmacol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1213\/ane.0b013e3181b0826a","article-title":"Should dosing of rocuronium in obese patients be based on ideal or corrected body weight?","volume":"109","author":"Meyhoff","year":"2009","journal-title":"Anesth Anal"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1399475\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T12:20:09Z","timestamp":1717071609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1399475\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":18,"alternative-id":["10.3389\/fmed.2024.1399475"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1399475","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,30]]},"article-number":"1399475"}}