{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:36Z","timestamp":1753891236657,"version":"3.41.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Riehl's melanosis is a pigmented dermatitis that manifests as brown-gray facial pigmentation with pigment incontinence and infiltration of cells in the upper dermis. The associated inflammation is induced by a variety of products such as drugs and cosmetics. Henna, commonly referred to as a hypoallergenic cosmetic, has been reported to cause Riehl's melanosis in some cases. Although skin depigmenting agents have been occasionally used, satisfactory results have not been obtained and no established therapeutic strategies exist to treat Riehl's melanosis. Meanwhile, picosecond lasers effectively treat other hyperpigmentation disorders. In this study, we report safe and effective treatment of henna induced-atypical Riehl's melanosis using a 755-nm picosecond Alexandrite laser. Immunohistochemical analyses revealed a potential role of CD8-positive lymphocytes in henna-induced inflammation and hyperpigmentation of the basal layer, and a role of melanophages in the pigmented dermis of Riehl's melanosis.<\/jats:p>","DOI":"10.3389\/fmed.2024.1401938","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:04:51Z","timestamp":1718197491000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Usefulness of a picosecond Alexandrite laser therapy on atypical henna-induced Riehl's melanosis inferred from immunohistochemical analyses"],"prefix":"10.3389","volume":"11","author":[{"given":"Mami","family":"Kishimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Iwayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Horita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3109\/14764172.2015.1007058","article-title":"Low-pulse energy Q-switched Nd: YAG laser treatment for hair-dye-induced Riehl's melanosis","volume":"17","author":"Hong","year":"2015","journal-title":"J Cosmet Laser Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1684\/ejd.2018.3404","article-title":"Acquired diffuse slate-gray facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients","volume":"28","author":"Woo","year":"2018","journal-title":"Eur J Dermatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s10103-020-03077-0","article-title":"Treatment of henna-induced Riehl's melanosis with a 755-nm picosecond Alexandrite laser","volume":"35","author":"Iwayama","year":"2020","journal-title":"Lasers Med Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.jaad.2018.07.047","article-title":"Comparison of the efficacy and safety of a picosecond Alexandrite laser and a Q-switched Alexandrite laser for the treatment of freckles in Chinese patients","volume":"79","author":"Yang","year":"2018","journal-title":"J Am Acad Dermatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"779","DOI":"10.5021\/ad.2017.29.6.779","article-title":"Treatment of melasma and post-inflammatory hyperpigmentation by a picosecond 755-nm Alexandrite laser in Asian patents","volume":"29","author":"Lee","year":"2017","journal-title":"Ann Dermatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1041492","DOI":"10.3389\/fmed.2022.1041492","article-title":"Case report: severe non-pigmenting fixed drug eruption showing general symptoms caused by chondroitin sulfate sodium","volume":"9","author":"Otsuka","year":"2022","journal-title":"Front Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e13626","DOI":"10.1111\/dth.13626","article-title":"NB-UVB irradiation attenuates inflammatory response in psoriasis","volume":"33","author":"Ye","year":"2020","journal-title":"Dermatol Therapy"},{"key":"B8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.abd.2021.03.001","article-title":"Phototherapy","volume":"96","author":"Barros","year":"2021","journal-title":"Anais Bras Dermatol"},{"unstructured":"Role of lymphocyte subpopulations in the immunopathogenesis of psoriasis and the effect of narrow band UVB phototherapy on the immunological profile of psoriasis patients105117\n            FattouhM\n            El-DinAN\n            El-HamdMA\n          29120583Egypt J Immunol242017","key":"B9"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1401938\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:04:54Z","timestamp":1718197494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1401938\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":9,"alternative-id":["10.3389\/fmed.2024.1401938"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1401938","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2024,6,11]]},"article-number":"1401938"}}