{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:20:15Z","timestamp":1768285215107,"version":"3.49.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Familial exudative retinopathy (FEVR) is a hereditary disease involving abnormal retinal vascular development in which macular heterotopia (MH) caused by mechanical-like pulling of the vitreous may lead to pseudo-strabismus. We describe the case of a 12-year-old male patient from China who presented to our hospital with a request for surgical correction of exotropia. Examination revealed that the strabismic appearance was due to MH, and dilated pupil examination of the peripheral fundus revealed that the blood vessels of the left eye and the macula were displaced toward the temporal retina by pulling, and further FFA examination was performed to diagnose FEVR. With good binocular vision and stereoscopic distance vision, corrective surgery for strabismus in this patient would have resulted in a hard-to-resolve diplopia. Therefore, it is important to identify FEVR combined with MH in clinical practice to avoid wrong diagnostic and treatment options.<\/jats:p>","DOI":"10.3389\/fmed.2024.1409074","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T05:06:28Z","timestamp":1724648788000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["FEVR combined with macular heterotopia in children presenting as pseudo-exotropia: a case report and literature review"],"prefix":"10.3389","volume":"11","author":[{"given":"Yujie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuimiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanghui","family":"Xiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.22608\/APO.201855","article-title":"Familial exudative vitreoretinopathy: pathophysiology, diagnosis, and management","volume":"7","author":"Tauqeer","year":"2018","journal-title":"Asia Pac J Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/s12886-022-02522-8","article-title":"Long-term clinical prognosis of 335 infant single-gene positive FEVR cases","volume":"22","author":"Chen","year":"2022","journal-title":"BMC Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/eye.2014.70","article-title":"Familial exudative vitreoretinopathy and related retinopathies","volume":"29","author":"Gilmour","year":"2015","journal-title":"Eye"},{"key":"ref4","first-page":"410","article-title":"Visual outcome in infants with cicatricial retinopathy of prematurity","volume":"32","author":"Birch","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1167\/iovs.03-1157","article-title":"Determination of the location of the fovea on the fundus","volume":"45","author":"Rohrschneider","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1055\/s-2008-1034686","article-title":"Disturbances of binocular vision in macular heterotopia","volume":"215","author":"Schroeder","year":"1999","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/0002-9394(75)90682-0","article-title":"Strabismus and pseudostrabismus with retrolental fibroplasia","volume":"79","author":"Foster","year":"1975","journal-title":"Am J Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1055\/s-0033-1350689","article-title":"Retinal exudative disease in childhood: Coats' disease and familial exudative vitreoretinopathy (FEVR)","volume":"230","author":"Joussen","year":"2013","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1001\/archopht.1993.01090080046017","article-title":"Prediction of visual function in eyes with mild to moderate posterior pole residua of retinopathy of prematurity. 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