{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:02:01Z","timestamp":1753891321419,"version":"3.41.2"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Malacoplakia is a rare chronic granulomatous disease that mostly affects the gastrointestinal tract and urinary tract of immunocompromised patients; malacoplakia rarely effects the female reproductive tract. Here, we report a 56-year-old patient who underwent thymectomy for thymoma and myasthenia gravis prior to developing cervical and vaginal malacoplakia. The patient presented with recurrent vaginal bleeding. We discovered that there were alterations in the cervical cauliflower pattern during colposcopy, which is suggestive of cervical cancer. Pathological examination of the lesion tissue showed that a large number of macrophages aggregated, and M-G bodies with concentric circles and refractive properties were observed between cells. Immunostaining for CD68 and CD163 was positive, and special staining for D-PAS and PAS was positive. The discovery of <jats:italic>Escherichia coli<\/jats:italic> in bacterial culture can aid in the diagnosis of malacoplakia. Following surgery, we performed vaginal lavage with antibiotics in addition to resection of local cervical and vaginal lesions. This study provides a fresh perspective on the management of genital malacoplakia.<\/jats:p>","DOI":"10.3389\/fmed.2024.1409239","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T05:27:44Z","timestamp":1717478864000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: A rare case of malacoplakia resembling a malignant tumor of the cervix: a case report and review of the literature"],"prefix":"10.3389","volume":"11","author":[{"given":"Jiaorong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1007\/s11255-023-03920-7","article-title":"Malakoplakia of urinary bladde: 3 cases reports and review","volume":"56","author":"Xia","year":"2024","journal-title":"Int Urol Nephrol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/PGP.0b013e31815788fc","article-title":"Concomitant malacoplakia and granuloma inguinale of the cervix in acquired immune deficiency syndrome","volume":"27","author":"Ramdial","year":"2008","journal-title":"Int J Gynecol Pathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.5858\/2008-132-113-CM","article-title":"Cutaneous malakoplakia","volume":"132","author":"Kohl","year":"2008","journal-title":"Arch Pathol Lab Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1365-2303.1991.tb00498.x","article-title":"Malacoplakia of the uterine cervix and endometrium","volume":"2","author":"Stewart","year":"1991","journal-title":"Cytopathology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1097\/00004347-198302000-00011","article-title":"Malacoplakia of the cervix and corpus uteri: a light microscopic, electron microscopic, and X-ray microprobe analysis of a case","volume":"2","author":"Will\u00e9n","year":"1983","journal-title":"Int J Gynecol Pathol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1080\/j.0001-6349.2004.077c.x","article-title":"Malacoplakia of the cervix uteri and vulva","volume":"83","author":"Agnarsd\u00f3ttir","year":"2004","journal-title":"Acta Obstet Gynecol Scand."},{"key":"B7","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/0002-9378(80)90134-9","article-title":"Malacoplakia of the female genital tract","volume":"138","author":"Chalvardjian","year":"1980","journal-title":"Am J Obstet Gynecol."},{"volume-title":"Malacoplakie van de tractus genitalis bij een vrouw met postmenopauzaal bloedverlies.","year":"2003","author":"Wiltenburg","key":"B8"},{"key":"B9","first-page":"691","article-title":"Malacoplakia of the uterine cervix: report of two cases","volume":"26","author":"Wahl","year":"1982","journal-title":"Acta Cytol"},{"key":"B10","first-page":"281","article-title":"Malacoplakia of the uterine cervix. 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