{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:48:41Z","timestamp":1765547321341,"version":"3.41.2"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Long COVID-19 symptoms may have a variety of potential overlapping causes. In this study, we aimed to investigate the potential correlation between abdominal adipose tissue and long COVID-19 symptoms in non-hospitalized patients in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective observational study. 424 subjects, recovered from COVID-19 for 2\u20134 weeks, were enrolled and 408 subjects were finished the follow-up investigation at baseline, 8<jats:sup>th<\/jats:sup> week and 12<jats:sup>th<\/jats:sup> week. Physical measurements were collected. Kaplan-Meier analysis and cox regression analysis were carried out to assess the correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 72 subjects reported the long COVID-19 symptoms. The adjusted Kaplan-Meier analysis and Cox regression analysis revealed a significant correlation with accumulated subcutaneous fat (SFA \u2265 2.0 dm<jats:sup>2<\/jats:sup>) and the long COVID-19 symptoms (<jats:italic>HR<\/jats:italic> = 2.63, <jats:italic>P<\/jats:italic> &amp;lt; 0.001 for male, <jats:italic>HR<\/jats:italic> = 1.52, P = 0.048 for female). However, overweight and central obesity showed positive correlation only in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study suggested that accumulated subcutaneous fat in abdomen (SFA \u2265 2.0 dm<jats:sup>2<\/jats:sup>) was an important positive factor associated with long COVID-19 symptoms among Chinese non-hospitalized patients. Large investigation and prospective studies are needed to validate the correlation in the future.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1410559","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T13:07:17Z","timestamp":1728911237000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Accumulated subcutaneous fat in abdomen is associated with long COVID-19 symptoms among non-hospitalized patients: a prospective observational 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