{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:24:25Z","timestamp":1790681065610,"version":"4.1.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    <jats:italic>Edwardsiella tarda<\/jats:italic>\n                    is frequently isolated from aquatic animals and environments. While human infections caused by\n                    <jats:italic>E. tarda<\/jats:italic>\n                    are rare, some extraintestinal infections can be severe. This case report describes a patient with cellulitis of the right upper extremity of unknown origin. Metagenomic next-generation sequencing (mNGS) indicated that the patient was infected with\n                    <jats:italic>E. tarda<\/jats:italic>\n                    . Antimicrobial susceptibility testing revealed that the isolate was resistant to quinolones and trimethoprim\/sulfamethoxazole. The isolate, positive for four virulence genes (\n                    <jats:italic>fimA, gadB, mukF<\/jats:italic>\n                    , and\n                    <jats:italic>sodB<\/jats:italic>\n                    ), was confirmed to be virulent using the\n                    <jats:italic>Galleria mellonella<\/jats:italic>\n                    larvae model. Following early pus drainage and a 9-day course of imipenem, the patient ultimately recovered. This case report aimed to illustrate the presentation, diagnosis, and management of uncommon cellulitis caused by drug-resistant, virulent\n                    <jats:italic>E. tarda<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fmed.2024.1413561","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:55:21Z","timestamp":1729040121000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["mNGS-identified cellulitis due to quinolone-resistant Edwardsiella tarda: a case report"],"prefix":"10.3389","volume":"11","author":[{"given":"Xuejin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danxia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1099\/00207713-15-1-33","article-title":"Edwardsiella, a new genus of Enterobacteriaceae based on a new species, E. tarda. 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