{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:19:44Z","timestamp":1785766784713,"version":"3.56.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the impact of corneas from donors over 80\u2009years of age on the activity of the North of France Tissue Bank and to determine the potential cost implications for banks using corneas from older donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data from a single-center retrospective cohort study of 6,023 corneas preserved at the Lille Tissue Bank between 2012 and 2023. Donors, unrestricted by age, were divided into two groups: younger (\u2264 80\u2009years) and older (&amp;gt; 80\u2009years). Corneas were categorized based on endothelial cell density (ECD). Data were collected from patients who underwent corneal transplantation. A financial impact model was created to assess the effects of using corneas from different age groups on the overall benefits of corneal transplant procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average donor age was 67.5 \u00b1 14.5\u2009years. The median age of donors gradually increased from 66 to 73\u2009years over the 12-year study period, with donors over 80\u2009years old representing more than 24% since 2021. Corneas from older donors had a higher discard rate (62.53% vs. 39.66%) due to poor endothelial quality and serological concerns (both <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.0001). Additionally, these corneas had lower ECD, with a larger proportion deemed unsuitable for grafting due to low ECD (30% vs. 8.2%). Corneas from younger donors were more often used for endothelial transplants, which require higher ECD. The mean economic benefit per cornea showed a moderate negative correlation with donor age. The net benefit of corneal transplants decreased as the proportion of donors aged over 80\u2009years increased. It is predicted that a net benefit of zero would be attained when the proportion of donors over 80\u2009years is 44.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using corneas from donors over 80\u2009years of age can help alleviate the shortage of donor tissue and be effective if certain quality standards are met. However, additional costs incurred by eye banks must be factored into this equation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1415515","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T04:51:10Z","timestamp":1729745470000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Medical and economic impacts of managing corneas from older donors at the tissue bank\u2014a single-center retrospective study spanning over 12 years"],"prefix":"10.3389","volume":"11","author":[{"given":"Anne-Sophie","family":"Hatzfeld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Germain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Maboudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Dhayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"i43","DOI":"10.1093\/bja\/aer398","article-title":"Tissue and corneal donation and transplantation in the UK","volume":"108","author":"Gaum","year":"2012","journal-title":"Br J Anaesth"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2147\/bsam.s114197","article-title":"The structure and evolution of eye banking: a review on eye banks\u2019 historical, present, and future contribution to corneal transplantation","volume":"5","author":"Lambert","year":"2017","journal-title":"J Biorepository Sci Appl Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/aos.13162","article-title":"Endothelium-in versus endothelium-out for Descemet membrane endothelial keratoplasty graft preparation and implantation","volume":"95","author":"Parekh","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s10561-020-09875-8","article-title":"Factors influencing endothelial cell density of corneas for transplantation","volume":"22","author":"Sampaio","year":"2021","journal-title":"Cell Tissue Bank"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.ophtha.2008.01.003","article-title":"The effect of donor age on corneal transplantation outcome results of the cornea donor study","volume":"115","author":"gal","year":"2008","journal-title":"Ophthalmology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1016\/j.ophtha.2013.08.026","article-title":"The effect of donor age on penetrating Keratoplasty for endothelial disease graft survival after 10 years in the cornea donor study","volume":"120","author":"Mannis","year":"2013","journal-title":"Ophthalmology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/eye.2009.312","article-title":"Influencing factors on the suitability of organ-cultured corneas","volume":"24","author":"Gavrilov","year":"2010","journal-title":"Eye"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1755-3768.2011.02271.x","article-title":"Influence of donor age, post-mortem time and cold storage on metabolic profile of human cornea","volume":"91","author":"Kryczka","year":"2011","journal-title":"Acta Ophthalmol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1136\/bjo.2006.112656","article-title":"Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study","volume":"91","author":"Niederer","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/s0886-3350(01)00925-7","article-title":"Behavior of corneal endothelial density over a lifetime","volume":"27","author":"Abib","year":"2001","journal-title":"J Cataract Refract Surg"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1136\/bjophthalmol-2015-306871","article-title":"(19) NHSB and TOTAG (OTAG AS). 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