{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:33:50Z","timestamp":1780925630918,"version":"3.54.1"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the relationship between hypertensive disorders of pregnancy (HDP) and adverse pregnancy outcomes and explore the risk factors for HDP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from the Maternal Near-Miss Surveillance System in Hunan Province, China, 2012\u20132022. Chi-square trend tests (<jats:italic>\u03c7<jats:sup>2<\/jats:sup><\/jats:italic><jats:sub>trend<\/jats:sub>) were used to determine trends in prevalence by year. Unadjusted odds ratios (uORs) were used to examine the association between HDP and adverse pregnancy outcomes. Multivariate logistic regression analysis (method: Forward, Wald, <jats:italic>\u03b1<\/jats:italic>\u202f=\u202f0.05) and adjusted odds ratios (aORs) were used to identify risk factors for HDP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study included 780,359 pregnant women, and 38,397 women with HDP were identified, with a prevalence of 4.92% (95% CI 4.87\u20134.97). The prevalence of preeclampsia-eclampsia, gestational hypertension, chronic hypertension, and chronic hypertension with superimposed preeclampsia was 2.28% (95% CI 2.25\u20132.31), 2.04% (95% CI 2.00\u20132.07), 0.43% (95% CI 0.41\u20130.44), and 0.18% (95% CI 0.17\u20130.19), respectively. From 2012 to 2022, the prevalence of HDP increased from 3.11 to 7.39%, showing an upward trend (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup><jats:sub>trend<\/jats:sub>\u202f=\u202f2220.88, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01). HDP was associated with the following adverse pregnancy outcomes: maternal deaths (uOR =4.05), maternal near-miss (uOR =6.37), preterm birth (uOR =2.51), stillbirth and neonatal death (uOR =1.45), low birthweight (uOR =4.37), abruptio placentae (uOR =4.45), uterine atony (uOR =1.49), retained placenta (uOR =1.54), puerperal infections (uOR =2.14), abdominal surgical site infections (uOR =2.50), urinary tract infections (uOR =1.60), upper respiratory tract infections (uOR =1.75), heart disease (uOR =2.76), embolism (uOR =2.66), liver disease (uOR =1.25), anemia (uOR =1.38), diabetes mellitus (uOR =2.35), renal disease (uOR =4.66), and pulmonary disease (uOR =4.70, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05). Results of multivariate logistic regression analysis showed risk factors for HDP: maternal age\u202f&amp;gt;\u202f30\u202fyears (aOR\u202f&amp;gt;\u202f1, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05), gravidity &amp;gt;\u202f=\u202f4 (aOR =1.10, 95% CI 1.05\u20131.14), primipara (aOR\u202f&amp;gt;\u202f1, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05), and previous cesarean sections (aOR =1.27, 95% CI 1.24\u20131.31).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of HDP was relatively high in Hunan Province. HDP was associated with many adverse pregnancy outcomes. Advanced maternal age, high gravidity, primipara, and previous cesarean section were risk factors for HDP.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1415696","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:29:55Z","timestamp":1734676195000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypertensive disorders of pregnancy in Hunan Province, China, 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Scand"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12884-018-1667-7","article-title":"Prevalence of hypertensive disorders of pregnancy in Ethiopia: a systemic review and meta-analysis","volume":"18","author":"Berhe","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1745506520973105","DOI":"10.1177\/1745506520973105","article-title":"Prevalence of hypertensive disorders of pregnancy and pregnancy outcomes in sub-Saharan Africa: a systematic review and meta-analysis","volume":"16","author":"Gemechu","year":"2020","journal-title":"Women\u2019s Health"},{"key":"ref10","volume-title":"A global brief on hypertension: silent killer, global public health crisis: World health day","year":"2013"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1161\/01.Hyp.0000054981.03589.E9","article-title":"Summary of the NHLBI working group on research on hypertension during 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services?","volume":"15","author":"Paredes","year":"2016","journal-title":"Int J Equity Health"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1016\/s0140-6736(16)31395-2","article-title":"Next generation maternal health: external shocks and health-system innovations","volume":"388","author":"Kruk","year":"2016","journal-title":"Lancet"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e0301145","DOI":"10.1371\/journal.pone.0301145","article-title":"The epidemiology of gestational diabetes, gestation hypertension, and anemia in North Palestine from 2018 to 2020: a retrospective study","volume":"19","author":"Damiri","year":"2024","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e236347","DOI":"10.1001\/jamanetworkopen.2023.6347","article-title":"Ozone exposure during pregnancy and risk of gestational hypertension or preeclampsia in China","volume":"6","author":"Cheng","year":"2023","journal-title":"JAMA Netw 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China","volume":"22","author":"Nwaru","year":"2012","journal-title":"Eur J Pub Health"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3389\/fneur.2018.00583","article-title":"The epidemiological characteristics of stroke in Hunan Province","volume":"9","author":"He","year":"2018","journal-title":"Front Neurol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"14048","DOI":"10.3390\/ijerph17114048","article-title":"Prevalence of overweight and obesity among people aged 18 years and over between 2013 and 2018 in Hunan, China","volume":"17","author":"Hua","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.midw.2019.06.005","article-title":"Changes of second-time mothers and their infants under the universal two-child policy in Changsha, China","volume":"77","author":"Liu","year":"2019","journal-title":"Midwifery"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e1226","DOI":"10.1016\/s2214-109x(21)00298-9","article-title":"Preterm births in China between 2012 and 2018: an observational study of more than 9 million women","volume":"9","author":"Deng","year":"2021","journal-title":"Lancet Glob Health"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"m997","DOI":"10.1136\/bmj.m997","article-title":"Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study","volume":"369","author":"Li","year":"2020","journal-title":"BMJ"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e13492","DOI":"10.1111\/1753-0407.13492","article-title":"Changes in the prevalence of diabetes and control of risk factors for diabetes among Chinese adults from 2007 to 2017: an analysis of repeated national cross-sectional surveys","volume":"16","author":"Jin","year":"2024","journal-title":"J Diabetes"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.puhe.2022.02.015","article-title":"Trends in maternal age and the relationship between advanced age and adverse pregnancy outcomes: a population-based register study in Wuhan, China, 2010-2017","volume":"206","author":"Cao","year":"2022","journal-title":"Public Health"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"9517","DOI":"10.3390\/ijerph17249517","article-title":"Prevalence, prevention and lifestyle intervention of gestational diabetes mellitus in China","volume":"17","author":"Juan","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1097\/aog.0000000000003020","article-title":"203: chronic hypertension in pregnancy","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e237","DOI":"10.1097\/aog.0000000000003891","article-title":"Gestational hypertension and preeclampsia","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/1471-0528.15427","article-title":"Maternal near-miss and death among women with hypertensive disorders in pregnancy: a secondary analysis of the Nigeria near-miss and maternal death survey","volume":"126","author":"Adamu","year":"2019","journal-title":"BJOG"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/hjh.0000000000003020","article-title":"Association of low birthweight and premature birth with hypertensive disorders in pregnancy: a systematic review and meta-analysis","volume":"40","author":"Tsujimoto","year":"2022","journal-title":"J 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