{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:02:33Z","timestamp":1753891353209,"version":"3.41.2"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Isolated corneal squamous cell carcinoma without conjunctiva and limbus involvement is rare. We report a case of isolated squamous cell carcinoma <jats:italic>in situ<\/jats:italic> of the cornea. A 67-year-old male presented with visual disturbance in the left eye (visual acuity, 0.5), with a lesion isolated to the cornea. After an initial diagnosis of keratitis, he was lost to follow-up for 15\u2009months. He subsequently returned for re-evaluation by a corneal specialist owing to progressive visual impairment in the left eye (visual acuity, 0.2). A left scrape biopsy and histopathological examination revealed squamous cell carcinoma <jats:italic>in situ<\/jats:italic>. No systemic evaluation findings of lymphadenopathy or metastasis were observed. Following removal of the residual mass from the cornea, conjunctival tissue samples, including the limbus, were collected for histopathological examination, with negative findings. No recurrence was observed at 15\u2009months postoperatively. Isolated corneal squamous cell carcinoma <jats:italic>in situ<\/jats:italic> can be misdiagnosed as simple corneal opacity or keratitis during clinical examination. This condition should be considered in patients with unresponsive keratitis or corneal opacities.<\/jats:p>","DOI":"10.3389\/fmed.2024.1418228","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T04:44:06Z","timestamp":1731559446000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: Squamous cell carcinoma in situ of the cornea without involvement of the limbus and conjunctiva"],"prefix":"10.3389","volume":"11","author":[{"given":"Ji Kyu","family":"Yun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Joon","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongwoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/s0039-6257(05)80054-2","article-title":"Ocular surface squamous neoplasia","volume":"39","author":"Lee","year":"1995","journal-title":"Surv Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1038\/s41433-021-01662-3","article-title":"Ocular surface squamous neoplasia in New Zealand: a ten-year review of incidence in the Waikato region","volume":"36","author":"Hossain","year":"2022","journal-title":"Eye"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s10792-007-9147-5","article-title":"Squamous cell carcinoma of Cornea","volume":"28","author":"Arya","year":"2008","journal-title":"Int Ophthalmol"},{"key":"ref4","first-page":"1621","article-title":"A case of conjunctival squamous cell carcinoma similar with herpetic keratitis","volume":"42","author":"Kim","year":"2001","journal-title":"J Korean Ophthalmol Soc"},{"key":"ref5","first-page":"300","article-title":"Squamous cell carcinoma of the conjunctiva","volume":"32","author":"Lee","year":"1991","journal-title":"J Korean Ophthalmol Soc"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/s0161-6420(86)33764-3","article-title":"Conjunctival and corneal intraepithelial and invasive neoplasia","volume":"93","author":"Erie","year":"1986","journal-title":"Ophthalmology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1016\/s0140-6736(96)91685-2","article-title":"Effect of ambient solar ultraviolet radiation on incidence of squamous-cell carcinoma of the eye","volume":"347","author":"Newton","year":"1996","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1001\/archopht.1992.01080160103042","article-title":"Incidence of ocular surface epithelial dysplasia in metropolitan Brisbane. A 10-year survey","volume":"110","author":"Lee","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/s0140-6736(95)90870-6","article-title":"Conjunctival squamous-cell carcinoma associated with Hiv infection in Kampala","volume":"345","author":"Ateenyi-Agaba","year":"1995","journal-title":"Uganda Lancet"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000502096","article-title":"P16 expression correlates with invasive ocular surface squamous neoplasms in Hiv-infected Mozambicans","volume":"6","author":"Carrilho","year":"2020","journal-title":"Ocul Oncol Pathol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1097\/ICO.0000000000002809","article-title":"Ocular surface squamous neoplasia with coexistent microbial keratitis: incidence, risk factors, clinical features, microbiological profile, and treatment outcome","volume":"41","author":"Kapoor","year":"2022","journal-title":"Cornea"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1080\/09286586.2021.1925307","article-title":"Racial and socioeconomic disparities in ocular surface squamous neoplasia: a National Cancer Database Analysis","volume":"29","author":"Zhang","year":"2022","journal-title":"Ophthalmic Epidemiol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1418228\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T04:44:08Z","timestamp":1731559448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1418228\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":12,"alternative-id":["10.3389\/fmed.2024.1418228"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1418228","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2024,11,14]]},"article-number":"1418228"}}