{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:01:48Z","timestamp":1753891308716,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>The genus Salmonella consists of Gram-negative bacteria with various serotypes. It commonly causes bacterial infections that affect the intestines. Infection can occur in humans and animals through the ingestion of contaminated food or water, or through contact with infected animals or environments. Complications commonly include intestinal hemorrhage and perforation, though vertebral osteomyelitis is rarely observed. Therefore, in patients with spinal cord abscesses, The genus Salmonella is typically not considered a likely pathogen, especially in the absence of typical symptoms. In this case, the limited information provided by traditional cultivation methods, particularly under the influence of antibiotics. However, next-generation sequencing (NGS) unexpectedly detected Salmonella, which assisted in formulating the final treatment plan. This underscores the role and clinical value of NGS in pathogen identification.<\/jats:p>","DOI":"10.3389\/fmed.2024.1419356","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T04:45:49Z","timestamp":1723783549000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Thoracic vertebral abscess caused by Salmonella via diagnosed next-generation sequencing"],"prefix":"10.3389","volume":"11","author":[{"given":"Xiao-guang","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-xi","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong-jian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"127631","DOI":"10.1016\/j.micres.2024.127631","article-title":"Epidemiology and antimicrobial resistance of salmonella serovars Typhimurium and 4,[5],12:i- recovered from hospitalized patients in China","volume":"282","author":"Nambiar","year":"2024","journal-title":"Microbiol Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"4220","DOI":"10.1007\/s00586-023-07707-3","article-title":"Pathogen detection in suspected spinal infection: metagenomic next-generation sequencing versus culture","volume":"32","author":"Huang","year":"2023","journal-title":"Eur Spine J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"704152","DOI":"10.3389\/fmicb.2021.704152","article-title":"Global genomic characterization of Salmonella enterica Serovar Telelkebir","volume":"12","author":"Qiu","year":"2021","journal-title":"Front Microbiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e0133323","DOI":"10.1128\/mbio.01333-23","article-title":"An integrated nationwide genomics study reveals transmission modes of typhoid fever in China","volume":"14","author":"Feng","year":"2023","journal-title":"MBio"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"mgen000401","DOI":"10.1099\/mgen.0.000401","article-title":"Genomic characterization of salmonella Uzaramo for human invasive infection","volume":"6","author":"Xu","year":"2020","journal-title":"Microb Genom"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"753085","DOI":"10.3389\/fmed.2022.753085","article-title":"Genomic investigation reveals a community typhoid outbreak caused by contaminated drinking water in China, 2016","volume":"9","author":"Hu","year":"2022","journal-title":"Front Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3944\/AOTT.2014.3107","article-title":"Endovascular treatment of an iliac artery rupture caused by invasive salmonella spondylodiscitis","volume":"48","author":"Kur\u015fun","year":"2014","journal-title":"Acta Orthop Traumatol Turc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1590\/S0004-282X2002000600029","article-title":"Espondilodiscite cervical espont\u00e2nea causada por Salmonella typhi em paciente imunocompetente [Spontaneous cervical spondylodiscitis caused by Salmonella typhi in an immunocompetent patient]","volume":"60","author":"Falavigna","year":"2002","journal-title":"Arq Neuropsiquiatr"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"206","DOI":"10.4184\/asj.2014.8.2.206","article-title":"Literature review and clinical presentation of cervical spondylitis due to salmonella enteritidis in immunocompetent","volume":"8","author":"Feng","year":"2014","journal-title":"Asian Spine J"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"C8","DOI":"10.1016\/j.vaccine.2015.02.030","article-title":"Diagnostics for invasive salmonella infections: current challenges and future directions","volume":"33","author":"Andrews","year":"2015","journal-title":"Vaccine"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1212\/CON.0000000000000930","article-title":"Infectious myelopathies","volume":"27","author":"Toledano","year":"2021","journal-title":"Continuum"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3390\/microorganisms8040476","article-title":"Spinal infections: an update","volume":"8","author":"Tsantes","year":"2020","journal-title":"Microorganisms"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12875-016-0433-z","article-title":"Primary care providers' experiences caring for complex patients in primary care: a qualitative study","volume":"17","author":"Loeb","year":"2016","journal-title":"BMC Fam Pract"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"5148","DOI":"10.3390\/jcm11175148","article-title":"Intramedullary spinal cord abscess with concomitant spinal degenerative diseases: a case report and systematic literature review","volume":"11","author":"Jabbar","year":"2022","journal-title":"J Clin Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1093\/jpids\/piab104","article-title":"Metagenomic next-generation sequencing for infectious disease diagnosis: a review of the literature with a focus on Pediatrics","volume":"10","author":"Edward","year":"2021","journal-title":"J Pediatric Infect Dis Soc"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"4818","DOI":"10.1039\/C6CS00693K","article-title":"Methods for the detection and identification of pathogenic bacteria: past, present, and future","volume":"46","author":"V\u00e1radi","year":"2017","journal-title":"Chem Soc Rev"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1419356\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T04:45:51Z","timestamp":1723783551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1419356\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":16,"alternative-id":["10.3389\/fmed.2024.1419356"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1419356","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2024,8,16]]},"article-number":"1419356"}}