{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:39:17Z","timestamp":1761845957268,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Acute cholecystitis is a common acute abdominal disease, but the occurrence of secondary gallbladder perforation is relatively rare, and poses a serious threat to the lives of patients. The conventional methods for diagnosing acute cholecystitis are abdominal contrast-enhanced CT and ultrasound. However, these methods may have limitations in detecting gallbladder perforation, especially in cases where perforation size are small. In contrast, contrast-enhanced ultrasound (CEUS) has the distinct advantage of providing dynamic, real-time visualization of the gallbladder wall enhancement, thereby enabling a more confident diagnosis of gallbladder perforation. Here, we report two cases of acute cholecystitis initially diagnosed by abdominal contrast-enhanced CT, and secondary gallbladder perforation detected by further contrast-enhanced ultrasound. Both patients were finally treated in a timely manner. Our cases suggest that CEUS can be an important complementary method for diagnosing gallbladder perforation.<\/jats:p>","DOI":"10.3389\/fmed.2024.1422708","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T04:24:41Z","timestamp":1733372681000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Improved detection of gallbladder perforation by contrast-enhanced ultrasound: two case reports"],"prefix":"10.3389","volume":"11","author":[{"given":"Yaxin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1001\/jama.2022.2350","article-title":"Acute cholecystitis: a review","volume":"327","author":"Gallaher","year":"2022","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.5005\/jp-journals-10018-1289","article-title":"Gallbladder perforation: a prospective study of its divergent appearance and management","volume":"9","author":"Patel","year":"2019","journal-title":"Euroasian J Hepatogastroenterol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1097\/JS9.0000000000000994","article-title":"Gallbladder perforation in acute acalculous vs. calculous cholecystitis: a retrospective comparative cohort study with 10-year single-center experience","volume":"110","author":"Lee","year":"2024","journal-title":"Int J Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.ajem.2008.04.024","article-title":"Can acute cholecystitis with gallbladder perforation be detected preoperatively by computed tomography in ED? 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