{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:51:09Z","timestamp":1780933869482,"version":"3.54.1"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Giant congenital pigmented nevi constitute an extremely diverse group of skin lesions with varying morphologies. These nevi are often associated with many clinical implications, such as increased risk of melanoma and the presence of neurocutaneous melanosis, with melanoma being the primary concern. We present a rare case of a 62-year-old patient with a giant congenital birthmark who reported to the oncology department due to a tumor in the lower abdomen detected during an ultrasound examination. A biopsy of the lesion showed the presence of melanoma metastasis. Four independent dermatologists performed a dermoscopic examination of the patient\u2019s skin and mucous membranes. In the PET\/CT examination, apart from the previously described change in the lower abdomen, no metabolically active foci with features of malignant growth were found. The patient underwent surgical removal of the lesion in the lower abdomen. The postoperative histopathological examination confirmed the presence of metastasis of melanoma in the subcutaneous tissue of the abdomen with no connection to the epidermis. The <jats:italic>BRAFV600<\/jats:italic> mutation was not found in the molecular test. For stage IV R0 melanoma with distant metastasis, with stage T0N0M1a, the only adjuvant treatment option following radical resection is nivolumab. After a rheumatological consultation, the patient was qualified for adjuvant treatment with nivolumab.<\/jats:p>","DOI":"10.3389\/fmed.2024.1427982","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T04:28:12Z","timestamp":1728966492000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolated melanoma metastasis in a patient with large congenital nevus without detectable primary melanoma: a case report and review of literature"],"prefix":"10.3389","volume":"11","author":[{"given":"Marta","family":"Pabianek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Jatczak-Grochala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Lesiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Narbutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Siekierko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Stasikowska-Kanicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Ci\u0105\u017cy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"ref1","volume-title":"International agency for research on cancer (IARC) GLOBOCAN","year":"2020"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.jaad.2021.03.109","article-title":"United States burden of melanoma and non-melanoma skin cancer from 1990 to 2019","volume":"85","author":"Aggarwal","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejca.2017.12.024","article-title":"Trends in incidence of thick, thin and in situ melanoma in europe","volume":"92","author":"Sacchetto","year":"2018","journal-title":"Eur J Cancer"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1002\/jso.25604","article-title":"Melanoma","volume":"120","author":"O\u2019Neill","year":"2019","journal-title":"J Surg Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1056\/NEJMoa1709030","article-title":"Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma","volume":"377","author":"Weber","year":"2017","journal-title":"The New England journal of medicine"},{"key":"ref6","first-page":"3925","volume-title":"J Clin Oncol","author":"Eggermont","year":"2020"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1200\/JCO.18.01219","article-title":"Longer follow-up confirms relapse-free survival benefit with adjuvant Dabrafenib plus Trametinib in patients with resected BRAF V600-mutant stage III melanoma","volume":"36","author":"Hauschild","year":"2018","journal-title":"J Clin Oncol"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.15586\/codon.noncutaneousmelanoma.2018.ch7","article-title":"Melanoma of unknown primary","volume-title":"Non cutaneous melanoma","author":"Scott","year":"2018"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.4103\/idoj.IDOJ_107_19","article-title":"Giant congenital melanocytic nevi successfully treated with combined laser therapy","volume":"11","author":"Sakhiya","year":"2020","journal-title":"Indian Dermatol Online J"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.jaad.2003.09.023","article-title":"A nonepidermal, primary malignant melanoma arising in a giant congenital melanocytic nevus 40 years after partial surgical removal","volume":"50","author":"Streams","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3889\/oamjms.2017.077","article-title":"Late onset achromatic melanoma arising in a Giant congenital melanocytic nevus","volume":"5","author":"Tchernev","year":"2017","journal-title":"Open Access Maced J Med Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1245\/s10434-018-6513-7","article-title":"Melanoma staging: American joint committee on Cancer (AJCC) 8th edition and beyond","volume":"25","author":"Gershenwald","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G","article-title":"The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. 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