{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:11:47Z","timestamp":1784891507814,"version":"3.55.0"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chlamydia abortus is a pathogen capable of infecting both humans and animals. In most known cases, this pathogen primarily infects pregnant women, leading to miscarriage and preterm birth. However, it is exceedingly rare for this pathogen to cause pneumonia that progresses to severe Acute Respiratory Distress Syndrome (ARDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case introduction<\/jats:title><jats:p>We present a case of a 76-year-old male patient who was clinically diagnosed with Acute Respiratory Distress Syndrome (ARDS) caused by Chlamydia abortus and successfully treated. The patient\u2019s condition rapidly deteriorated over six days, evolving from a lung infection to severe pneumonia, ultimately leading to ARDS and sepsis. Initially, he was admitted to a local hospital for a lung infection where routine etiological examinations failed to identify any significant pathogens, and he received only empirical antimicrobial therapy. However, the lung infection was not controlled, and the patient\u2019s condition rapidly worsened, resulting in severe respiratory distress. This necessitated tracheal intubation and assisted ventilation, after which he was transferred to our hospital for treatment. Due to the patient\u2019s family\u2019s inability to afford the cost of ECMO treatment, we adopted a prone positioning ventilation strategy to improve the patient\u2019s ventilation-perfusion matching. Additionally, we performed metagenomic next-generation sequencing on the patient\u2019s bronchoalveolar lavage fluid, which confirmed the infection with Chlamydia abortus. These measures ultimately led to the successful treatment of the patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chlamydia abortus infection can lead to severe ARDS, necessitating timely diagnosis and active intervention by clinicians. This case highlights the crucial role of metagenomic next-generation sequencing in diagnosing rare pathogens. Timely adoption of prone positioning ventilation can significantly improve ventilation-perfusion matching, effectively treating ARDS caused by Chlamydia abortus. Additionally, the combination of moxifloxacin and piperacillin-tazobactam can treat ARDS caused by Chlamydia abortus.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1428300","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T04:39:48Z","timestamp":1726115988000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prone positioning ventilation treatment rescuing a patient with chlamydia abortus-induced ARDS diagnosed by next generation sequencing: a case report"],"prefix":"10.3389","volume":"11","author":[{"given":"Yi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kechun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1024\/0036-7281.144.9.463","article-title":"Abortion in humans caused by Chlamydophila abortus (Chlamydia psittaci serovar 1).","volume":"144","author":"Pospischil","year":"2002","journal-title":"Schweiz Arch Tierheilkd."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1097\/01.AOG.0000161060.69470.9c","article-title":"An unusual cause of sepsis during pregnancy: Recognizing infection with Chlamydophila abortus.","volume":"106","author":"Walder","year":"2005","journal-title":"Obst Gynecol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3201\/eid2603.191417","article-title":"Chlamydia abortus in pregnant woman with acute respiratory distress syndrome.","volume":"26","author":"Pichon","year":"2020","journal-title":"Emerg Infect Dis."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-022-01052-x","article-title":"Recent advances and public health implications for environmental exposure to Chlamydia abortus: From enzootic to zoonotic disease. Recent advances and public health implications for environmental exposure to Chlamydia abortus: From enzootic to zoonotic disease.","volume":"53","author":"Turin","year":"2022","journal-title":"Vet Res."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s13620-016-0067-4","article-title":"Isolation of Chlamydia abortus from a laboratory worker diagnosed with atypical pneumonia.","volume":"69","author":"Ortega","year":"2015","journal-title":"Ir Vet J."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07158-z","article-title":"Bloodstream infection and pneumonia caused by Chlamydia abortus infection in China: A case report.","volume":"22","author":"Zhu","year":"2022","journal-title":"BMC Infect Dis."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00756-8","article-title":"Septic shock with Chlamydia abortus infection.","volume":"22","author":"Liu","year":"2022","journal-title":"Lancet Infect Dis."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2022.w30102","article-title":"Zoonotic Chlamydiae as rare causes of severe pneumonia.","volume":"152","author":"Imkamp","year":"2022","journal-title":"Swiss Med Wkly."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3893","DOI":"10.2147\/IDR.S411331","article-title":"Extracorporeal membrane oxygenation in severe acute respiratory distress syndrome caused by Chlamydia abortus: A case report.","volume":"16","author":"Huang","year":"2023","journal-title":"Infect Drug Resist."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1164\/rccm.201308-1532CI","article-title":"Prone position in acute respiratory distress syndrome. Rationale, indications, and limits.","volume":"188","author":"Gattinoni","year":"2013","journal-title":"Am J Respir Crit Care Med."},{"key":"B11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1164\/ajrccm.150.1.8025748","article-title":"Mechanism by which the prone position improves oxygenation in acute lung injury.","volume":"150","author":"Lamm","year":"1994","journal-title":"Am J Respir Crit Care Med."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03552-2","article-title":"Prone position in intubated, mechanically ventilated patients with COVID-19: A multi-centric study of more than 1000 patients.","volume":"25","author":"Langer","year":"2021","journal-title":"Crit Care."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1157540","article-title":"Clinical identification and microbiota analysis of Chlamydia psittaci- and Chlamydia abortus- pneumonia by metagenomic next-generation sequencing.","volume":"13","author":"Xie","year":"2023","journal-title":"Front Cell Infect Microbiol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1428300\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T04:39:51Z","timestamp":1726115991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1428300\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":13,"alternative-id":["10.3389\/fmed.2024.1428300"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1428300","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"article-number":"1428300"}}