{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:14:46Z","timestamp":1790007286770,"version":"4.0.1"},"reference-count":130,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Obesity in adults is a known risk factor for cardiovascular events and is associated with a decline in arterial elasticity. This study aims to evaluate the utility of pulse wave analysis (PWA) parameters in routine clinical practice for the primary prevention of cardiovascular events by developing a prediction model for arterial stiffness among obese and overweight individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study enrolled 84 adult patients, aged 18 to 85 years, with varying degrees of weight status, including optimal weight, overweight, and obesity. The lifestyle habits, the personal and family history of cardiometabolic diseases, as well the clinical evaluation that included BMI (body mass index), WHR (waist-to-hip ratio), WC (waist circumferance) were performed. PWA evaluation was conducted using the Mobil-O-Graph device, assessing the following parameters: pulse wave velocity (PWV), augmentation index (AIx), heart rate (HR), central pulse pressure (cPP), peripheral and central blood pressure (SBP, DBP, cSBP, cDBP). Body composition analysis was performed using the TANITA BC-418 body analyzer. Laboratory results from the past 3 months were also collected during initial nutritional consultations for each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Family history of cardiovascular events showed positive correlations with all PWA parameters, while diabetes history only with PWV and family history of obesity with PWV, DBP, and cSBP. Insufficient sleep duration showed positive associations with all arterial stiffness parameters except cDBP. Smoking status correlated with significantly elevated PWV and Aix values, while insufficient physical activity was associated solely with PWV. Positive correlations were showed between current weight and PWV, while WC demonstrated positive associations with PWV, SBP, and cSBP. Body composition analysis revealed significant associations between trunk adipose tissue mass (%) and PWV, SBP, and cSBP. Hydration status (%) emerged as an independent predictor for PWV, exhibiting an inverse relationship. HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) showed a strong positive correlation with PWV. Negative associations were observed with HDL-c and vitamin D. Threshold values for age, cDBP and Cardiac Index providing positive diagnostic for vascular impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The assessment of arterial stiffness can be considered a reliable approach to prevent obesity-related cardiovascular events and facilitate the comprehensive management of such pathologies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1430437","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T17:48:35Z","timestamp":1724089715000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a comprehensive risk prediction model for arterial stiffness assessment in individuals with obesity"],"prefix":"10.3389","volume":"11","author":[{"given":"Denisa","family":"Pescari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Borlea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simina","family":"Mihuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Stoian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1161\/CIRCRESAHA.121.318093","article-title":"Obesity, adipose tissue, and vascular dysfunction","volume":"128","author":"Koenen","year":"2021","journal-title":"Circ Res."},{"key":"B2","unstructured":"GenevaWorld Health OrganizationObesity and Overweight.2021"},{"key":"B3","unstructured":"Adult Obesity Prevalence Maps2023"},{"key":"B4","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1161\/01.CIR.67.5.968","article-title":"Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study","volume":"67","author":"Hubert","year":"1983","journal-title":"Circulation."},{"key":"B5","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3390\/app13010610","article-title":"A review of the relationship between gut microbiome and obesity","volume":"13","author":"Zs\u00e1lig","year":"2023","journal-title":"Appl Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1161\/01.CIR.0000161369.71722.10","article-title":"Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment","volume":"111","author":"Daniels","year":"2005","journal-title":"Circulation."},{"key":"B7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1001\/jamacardio.2018.0022","article-title":"Association of body mass index with lifetime risk of cardiovascular disease and compression of morbidity","volume":"3","author":"Khan","year":"2018","journal-title":"JAMA Cardiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N Engl J Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.3390\/jcm11164843","article-title":"Arterial stiffness\u2014what do we know about it and what do we expect from this biomarker?","volume":"11","author":"Reiner","year":"2022","journal-title":"J Clin Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.3390\/nu15061440","article-title":"The influence of dietary interventions on arterial stiffness in overweight and obese subjects","volume":"15","author":"Stanek","year":"2023","journal-title":"Nutrients"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1210\/en.2015-1681","article-title":"Endothelial estrogen receptor-\u03b1 does not protect against vascular stiffness induced by Western diet in female mice","volume":"157","author":"Manrique","year":"2016","journal-title":"Endocrinology."},{"key":"B12","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1080\/pdp.21.2.213.237","article-title":"Natural history and risk factors of atherosclerosis in children and youth: the PDAY study","volume":"21","author":"Zieske","year":"2002","journal-title":"Pediatr Pathol Mol Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e984","DOI":"10.1161\/CIR.0000000000000973","article-title":"Obesity and cardiovascular disease: a scientific statement from the American heart association","volume":"143","author":"Powell-Wiley","year":"2021","journal-title":"Circulation."},{"key":"B14","first-page":"289","article-title":"Co spojuje obezitu a ateroskler\u00f3zu? 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