{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:14:04Z","timestamp":1792610044177,"version":"4.5.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012632","name":"Nazarbayev University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Endometriosis is a condition affecting reproductive-age women and associated with dysmenorrhea, pelvic organs dysfunction, pelvic pain, and infertility. The real epidemiology of endometriosis remains underestimated. No data are available on prevalence of endometriosis in Kazakhstan. Therefore, the aim of this was to investigate the epidemiology, complications, surgical management approach, and outcomes of endometriosis in Kazakhstan by analyzing large-scale Kazakhstani healthcare data from the Unified Nationwide Electronic Health System (UNEHS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population-based study among women with endometriosis treated in any healthcare setting of the Republic of Kazakhstan during the period of 2014\u20132019 was performed. The International Classification of Diseases (ICD) 10th edition was used to retrieve data on endometriosis (\u201cN80\u201d and \u201cN97\u201d). ICD 9th edition\u2019s procedural codes were utilized to retrieve information on surgical procedures performed to manage patients with endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 7,682 records of women diagnosed with endometriosis were analyzed from all Kazakhstani regions. The overall prevalence of endometriosis among Kazakhstani female population was 0.12%, with 50.1% of them suffering from endometriosis of the uterus, 34.5% with ovarian endometriosis, and 9.5% with endometriosis of pelvic peritoneum. The most affected group was reproductive-age women (25\u201344 years old). Endometriosis rates were higher among women of 35\u201339, 40\u201344, and 45\u201349 years old age groups \u2013 0.4 per 1000 women of corresponding age. The most common procedures performed for surgical management were laparoscopic cystectomy and closed biopsy of the uterus, 16.4 and 13.5%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among all registered cases of endometriosis, ovarian endometriosis is the most prevalent condition. However, the analysis of the UNEHS records on endometriosis reveals incomplete and inconsistent registration of the disease, which results in the underestimation of the disease\u2019s real burden. Clinical specialist and health authorities in Kazakhstan must work to ensure the endometriosis proper diagnosis end registration to improve the disease management and outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1436458","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T05:35:54Z","timestamp":1736228154000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiology of endometriosis in Kazakhstan: a national population-based cohort analysis (2014\u20132019) using data from the national electronic healthcare system"],"prefix":"10.3389","volume":"11","author":[{"given":"Gulzhanat","family":"Aimagambetova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesbolat","family":"Sakko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talshyn","family":"Ukybassova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Terzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizada","family":"Marat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazira","family":"Kamzayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnur","family":"Gusmanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnur","family":"Zhakhina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sauran","family":"Yerdessov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla","family":"Mussina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy","family":"Syssoyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abduzhappar","family":"Gaipov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.23736\/S0026-4806.19.06346-8","article-title":"Ovulation induction in infertile women with endometriotic ovarian cysts: current evidence and potential pitfalls.","volume":"111","author":"Terzic","year":"2020","journal-title":"Minerva Med"},{"key":"B2","first-page":"31","article-title":"Endometriotic cyst and infertility.","author":"Aimagambetova","year":"2021","journal-title":"Advances in Health and Disease."},{"key":"B3","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations.","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179274","article-title":"Molecular basis of endometriosis and endometrial cancer: current knowledge and future perspectives.","volume":"22","author":"Terzic","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.fertnstert.2023.03.006","article-title":"Endometriosis and adenomyosis: shared pathophysiology.","volume":"119","author":"Bulun","year":"2023","journal-title":"Fertil Steril."},{"key":"B6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bpobgyn.2020.08.005","article-title":"The epidemiology of endometriosis is poorly known as the pathophysiology and diagnosis are unclear. 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