{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:23:43Z","timestamp":1769505823044,"version":"3.49.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ultrasound-guided microwave ablation (MWA) has become a popular method for treating malignant liver tumors. However, few studies have investigated its use in the treatment of hepatoalveolar echinococcosis (HAE). This study aimed to explore the effectiveness and safety of contrast-enhanced ultrasound combined with two-dimensional ultrasound-guided MWA for the treatment of HAE in difficult\/dangerous locations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 81 patients, who were diagnosed with hepatic alveolar hydatid disease in difficult\/dangerous locations between January 2018 and January 2023, and underwent contrast-enhanced ultrasonography combined with two-dimensional ultrasound-guided MWA, were analyzed. After undergoing MWA, patients were followed up to determine whether the lesions recurred and to evaluate the therapeutic effect of MWA. Preoperatively, individualized strategies were designed for lesions in different locations, and different auxiliary ablation technologies were used for contrast-enhanced ultrasound combined with two-dimensional ultrasound-guided MWA to achieve complete inactivation of lesions in difficult\/dangerous locations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MWA was performed on 89 HAE lesions in 81 patients. The median diameter of the lesions was 2.86\u2009cm (interquartile range [IQR] 2.36\u20133.49\u2009cm). The complete ablation rate after surgery was 100%, with a recurrence rate of 11.11%, and median follow-up of 24\u2009months (IQR 12\u201348\u2009months). The incidence of minor complications was 14.81%; no serious complications or deaths occurred. Compared with before surgery, TB, DB, alanine aminotransferase, and aspartate aminotransferase levels increased (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), albumin platelets and activated partial thromboplastin time decreased (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05), with no statistical difference in prothrombin time (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MWA may be a safe and effective method for treating HAE in difficult\/dangerous locations, and may represent a new and alternative option for this patient population.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1436753","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T04:40:37Z","timestamp":1723178437000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of percutaneous microwave ablation guided by contrast-enhanced and two-dimensional ultrasound for in hepatic alveolar echinococcosis in difficult\/dangerous locations"],"prefix":"10.3389","volume":"11","author":[{"given":"Wangxing","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1097\/00001432-200310000-00010","article-title":"Echinococcus 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(Oxford)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e7137","DOI":"10.1097\/MD.0000000000007137","article-title":"Efficacy and safety of ultrasound-guided percutaneous microwave ablation for the treatment of hepatic alveolar echinococcosis: a preliminary study","volume":"96","author":"Cairang","year":"2017","journal-title":"Medicine"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jus.2012.09.001","article-title":"Contrast enhanced ultrasound: roles in immediate post-procedural and 24-h evaluation of the effectiveness of thermal ablation of liver tumors","volume":"15","author":"Meloni","year":"2012","journal-title":"J Ultrasound"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/j.1440-1673.2007.01871.x","article-title":"Post-radiofrequency ablation syndrome after percutaneous radiofrequency of abdominal tumours: one Centre experience and review of published works","volume":"51","author":"Carrafiello","year":"2007","journal-title":"Australas Radiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.clinimag.2022.02.019","article-title":"Re: liver tumor ablation in difficult locations: microwave ablation of perivascular and subdiaphragmatic hepatocellular carcinoma","volume":"85","author":"Ozen","year":"2022","journal-title":"Clin Imaging"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1148\/radiol.2433060157","article-title":"Percutaneous radiofrequency ablation of hepatic tumors against the diaphragm: frequency of diaphragmatic injury","volume":"243","author":"Head","year":"2007","journal-title":"Radiology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3109\/02656736.2012.665565","article-title":"Percutaneous microwave ablation for liver cancer adjacent to the diaphragm","volume":"28","author":"Li","year":"2012","journal-title":"Int J Hyperth"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s00535-003-1181-0","article-title":"Risk factors for the local recurrence of hepatocellular carcinoma after a single session of percutaneous radiofrequency ablation","volume":"38","author":"Hori","year":"2003","journal-title":"J Gastroenterol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3109\/02656736.2014.891765","article-title":"Efficacy and safety of artificial ascites in assisting percutaneous microwave ablation of hepatic tumours adjacent to the gastrointestinal tract","volume":"30","author":"Zhang","year":"2014","journal-title":"Int J Hyperth"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s12072-015-9639-8","article-title":"Artificial ascites is feasible and effective for difficult-to-ablate hepatocellular carcinoma","volume":"9","author":"Wang","year":"2015","journal-title":"Hepatol Int"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"830","DOI":"10.5732\/cjc.010.10095","article-title":"Percutaneous ultrasound-guided thermal ablation for liver tumor with artificial pleural effusion or ascites","volume":"29","author":"Liu","year":"2010","journal-title":"Chin J Cancer"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.ejrad.2013.12.015","article-title":"Percutaneous microwave ablation for hepatocellular carcinoma adjacent to large vessels: a long-term follow-up","volume":"83","author":"Huang","year":"2014","journal-title":"Eur J Radiol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.clinimag.2020.11.010","article-title":"Liver tumor ablation in difficult locations: microwave ablation of perivascular and subdiaphragmatic hepatocellular carcinoma","volume":"71","author":"Makovich","year":"2021","journal-title":"Clin Imaging"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12880-022-00752-2","article-title":"Effectiveness and safety of ultrasound-guided percutaneous microwave ablation for hepatic alveolar echinococcosis","volume":"22","author":"Deng","year":"2022","journal-title":"BMC Med Imaging"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"20191025","DOI":"10.1259\/bjr.20191025","article-title":"Efficacy and safety of percutaneous microwave ablation for hepatocellular carcinomas <4 cm in difficult location","volume":"93","author":"Mukund","year":"2020","journal-title":"Br J 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