{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:33:30Z","timestamp":1792100010187,"version":"4.4.0"},"reference-count":116,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>This review summarizes the research progress over the past 30 years on the relationship between <jats:italic>Mycoplasma pneumoniae<\/jats:italic> infection and chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and bronchiectasis. <jats:italic>Mycoplasma pneumoniae<\/jats:italic> is a common cause of community-acquired pneumonia, particularly in children and young adults. Key findings from recent studies indicate that <jats:italic>M. pneumoniae<\/jats:italic> infection is associated with a higher risk of asthma exacerbations and may contribute to the development of bronchiectasis in susceptible individuals. Additionally, emerging evidence suggests that <jats:italic>M. pneumoniae<\/jats:italic>-induced immune dysregulation plays a crucial role in the pathogenesis of chronic lung diseases. This review aims to summarize the current understanding of the potential links between <jats:italic>M. pneumoniae<\/jats:italic> pneumonia and various chronic respiratory conditions, including asthma, chronic obstructive pulmonary disease (COPD), and bronchiectasis. We discuss the epidemiological data, pathogenic mechanisms, clinical manifestations, and long-term consequences of <jats:italic>M. pneumoniae<\/jats:italic>-related respiratory illnesses. Additionally, we highlight the challenges in diagnosis and treatment, as well as future research directions in this field.<\/jats:p>","DOI":"10.3389\/fmed.2024.1437731","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T12:40:04Z","timestamp":1727268004000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["A comprehensive review of Mycoplasma pneumoniae infection in chronic lung diseases: recent advances in understanding asthma, COPD, and bronchiectasis"],"prefix":"10.3389","volume":"11","author":[{"given":"Zai-qiang","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-yi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-ying","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/jgf2.15","article-title":"Mycoplasma pneumoniae infection: basics","volume":"18","author":"Saraya","year":"2017","journal-title":"J Gen Fam Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1128\/CMR.17.4.697-728.2004","article-title":"Mycoplasma 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