{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:26:23Z","timestamp":1764433583592,"version":"3.41.2"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>This paper reports a case of pseudolithiasis caused by the use of ceftriaxone sodium. The patient, a 54-year-old female, presented with intermittent abdominal pain and distension for 1 month. Initial ultrasonography showed no abnormalities. However, after receiving ceftriaxone sodium treatment for an upper respiratory tract infection, she developed discomfort in the right upper abdomen. A CT scan subsequently diagnosed her with gallbladder stones. Six weeks after discontinuing the medication, a follow-up examination revealed the disappearance of the stones, confirming the diagnosis of drug-induced pseudolithiasis. Through a literature review, this paper summarizes the mechanism, clinical manifestations, diagnostic methods, and treatment recommendations of ceftriaxone sodium-induced pseudolithiasis, providing a reference for clinical safe medication use.<\/jats:p>","DOI":"10.3389\/fmed.2024.1445228","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:24:59Z","timestamp":1732681499000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A case report and literature review: one case of ceftriaxone sodium-induced reversible gallbladder stone"],"prefix":"10.3389","volume":"11","author":[{"given":"Changqin","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingmin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"B1","first-page":"569","article-title":"Acute pancreatitis associated with the administration of ceftriaxone in an adult patient","volume":"106","author":"Sasaki","year":"2009","journal-title":"Nihon Shokakibyo Gakkai Zasshi."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1016\/0016-5085(91)90667-A","article-title":"Ceftriaxone-associated gallbladder sludge. Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate","volume":"100","author":"Park","year":"1991","journal-title":"Gastroenterology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/jac\/10.3.207","article-title":"Ceftriaxone: renal and biliary excretion and effect on the colon microflora","volume":"10","author":"Arvidsson","year":"1982","journal-title":"J Antimicrob Chemother."},{"key":"B4","first-page":"675","article-title":"Drug induced lithiases","volume":"27","author":"Daudon","year":"1998","journal-title":"Presse Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/(SICI)1097-0096(200005)28:4<166::AID-JCU2>3.0.CO;2-G","article-title":"Sonographic assessment of ceftriaxone-associated biliary pseudolithiasis in children","volume":"28","author":"Palanduz","year":"2000","journal-title":"J Clin Ultrasound"},{"key":"B6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/jcu.20228","article-title":"Ceftriaxone-associated biliary pseudolithiasis in children","volume":"34","author":"Biner","year":"2006","journal-title":"J Clin Ultrasound."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1136\/adc.2003.044156","article-title":"Nephrolithiasis associated with ceftriaxone therapy: a prospective study in 51 children","volume":"89","author":"Avci","year":"2004","journal-title":"Arch Dis Child."},{"key":"B8","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1440-1746.1992.tb01496.x","article-title":"Gall-bladder sludge: lessons from ceftriaxone","volume":"7","author":"Kim","year":"1992","journal-title":"J Gastroenterol Hepatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e04924","DOI":"10.1002\/ccr3.4924","article-title":"Gallstone ileus: a rare cause of small intestine obstruction","volume":"9","author":"Mulita","year":"2021","journal-title":"Clin Case Rep."},{"key":"B10","first-page":"113","article-title":"Ceftriaxone-associated biliary pseudolithiasis","volume":"67","author":"Rienstra","year":"2009","journal-title":"Neth J Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1016\/S0140-6736(88)90596-X","article-title":"Reversible ceftriaxone-associated biliary pseudolithiasis in children","volume":"2","author":"Schaad","year":"1988","journal-title":"Lancet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1128\/AAC.34.6.1146","article-title":"Apparent biliary pseudolithiasis during ceftriaxone therapy","volume":"34","author":"Heim-Duthoy","year":"1990","journal-title":"Antimicrob Agents Chemother."},{"key":"B13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1179\/027249304225013349","article-title":"Gallbladder and urinary tract precipitations associated with ceftriaxone therapy in children: a prospective study","volume":"24","author":"Acun","year":"2004","journal-title":"Ann Trop Paediatr."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1364841","DOI":"10.3389\/fnut.2024.1364841","article-title":"Causal association of plasma circulating metabolites with nephritis: a Mendelian randomization study","volume":"11","author":"Shao","year":"2024","journal-title":"Front Nutr."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1445228\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:25:02Z","timestamp":1732681502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1445228\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":14,"alternative-id":["10.3389\/fmed.2024.1445228"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1445228","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"article-number":"1445228"}}