{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:46:10Z","timestamp":1778071570079,"version":"3.51.4"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Neurotrophic tyrosine receptor kinase (NTRK) fusions are infrequent genetic events that can occur in various tumor types. Specifically, NTRK-rearranged sarcoma has been observed in pediatric mesenchymal tumors and, to a lesser extent, in adult mesenchymal tumors like fibrosarcoma. Recently, NTRK-rearranged uterine sarcoma (US) has been identified as a rare entity characterized by constitutive activation or overexpression of the TRK receptor, which plays a role in cell proliferation and differentiation. Since its initial description in 2018, only 46 cases of NTRK-rearranged US have been reported. In this context, herein we describe an exceptional case of an <jats:italic>STRN3::NTRK3<\/jats:italic> fused US with histologically confirmed splenic metastasis. Notably, such localization has not been previously associated with pure uterine sarcomas in the literature. The fusion involved <jats:italic>STRN3<\/jats:italic> (exon-3) and <jats:italic>NTRK3<\/jats:italic> (exon-14) genes and was identified through next-generation sequencing analysis. Recognizing this specific molecular rearrangement is crucial, as it not only enables targeted therapy but also holds diagnostic significance in specific clinical scenarios.<\/jats:p>","DOI":"10.3389\/fmed.2024.1448491","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:27:51Z","timestamp":1731040071000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case report: STRN3-NTRK3 fusion in uterine sarcoma with spleen metastasis: a new variant in the spectrum of NTRK-rearranged tumors"],"prefix":"10.3389","volume":"11","author":[{"given":"Piergiuseppe","family":"Colombo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina Adriana","family":"Buonamassa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Giulianini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"Rudini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Carnaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salumeh","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"Mongiov\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Pafumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Marletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/his.14008","article-title":"Uterine mesenchymal tumours: recent advances","volume":"76","author":"Momeni-Boroujeni","year":"2020","journal-title":"Histopathology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/gcc.22910","article-title":"NTRK and other recently described kinase fusion positive uterine sarcomas: a review of a group of rare neoplasms","volume":"60","author":"Croce","year":"2021","journal-title":"Genes Chromosomes Cancer"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1097\/PAS.0000000000001055","article-title":"NTRK fusions define a novel uterine sarcoma subtype with features of fibrosarcoma","volume":"42","author":"Chiang","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00428-023-03724-1","article-title":"NTRK-rearranged spindle cell sarcoma of the uterine cervix with a novel NUMA1::NTRK1 fusion","volume":"484","author":"Szalai","year":"2024","journal-title":"Virchows Arch"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1097\/PAS.0000000000001929","article-title":"NTRK -rearranged uterine sarcomas: clinicopathologic features of 15 cases, literature review, and risk stratification","volume":"46","author":"Costigan","year":"2022","journal-title":"Am J Surg Pathol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1097\/PAS.0000000000001292","article-title":"STRN-NTRK3-rearranged mesenchymal tumor of the uterus: expanding the morphologic spectrum of tumors with NTRK fusions","volume":"43","author":"Michal","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"ref7","volume-title":"WHO classification of tumors. 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