{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:07:35Z","timestamp":1784671655232,"version":"3.55.0"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Parabacteroides goldsteinii,<\/jats:italic> a member of the <jats:italic>Parabacteroides genus<\/jats:italic>, was initially discovered in the feces and abdominal tissue of patients with appendicitis, peritonitis, and abdominal abscesses. In recent years, <jats:italic>P. goldsteinii<\/jats:italic> has been widely regarded as a gut probiotic, and human infections have been extremely rare. In 2010, <jats:italic>P. goldsteinii<\/jats:italic> was first isolated from the blood culture of a patient with abdominal infection, confirming its ability to cause bacteremia. In this study, we report a rare case of puerperal infection with septic shock caused by <jats:italic>P. goldsteinii<\/jats:italic> infection in a pregnant woman.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 31-year-old female experienced perineal lacerations, cervical lacerations, and postpartum hemorrhage during childbirth. Nine days postpartum, the patient developed septic shock, and <jats:italic>P. goldsteinii<\/jats:italic> infection was identified through blood culture and mass spectrometry. We administered broad-spectrum antibiotics, including meropenem\/nalidixic acid and piperacillin tazobactam, intravenously, but the antimicrobial effect was not satisfactory. Upon ultrasound examination, we identified a focus of infection in the patient\u2019s uterus. Subsequently, uterine curettage was performed, followed by uterine cavity irrigation with metronidazole and intramuscular injection of gentamicin and dexamethasone. Following treatment, the patient\u2019s physiological parameters gradually returned to normal, and she was discharged 30\u2009days after admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Parabacteroides goldsteinii<\/jats:italic> bacteraemia is extremely rare, and clinically, the postinfection toxicity of this bacterium appears to be significant. In this report, we review the research history of <jats:italic>P. goldsteinii<\/jats:italic> and relevant infection cases, aiming to enhance awareness among clinical practitioners, particularly obstetricians and gynecologists, regarding <jats:italic>P. goldsteinii<\/jats:italic> bloodstream infections, facilitating early diagnosis and timely treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1450931","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T04:39:42Z","timestamp":1723178382000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal puerperal infection caused by Parabacteroides goldsteinii: a case report"],"prefix":"10.3389","volume":"11","author":[{"given":"Liwei","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjiang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4522","DOI":"10.1128\/JCM.43.9.4522-4527.2005","article-title":"\"Bacteroides goldsteinii sp. nov.\" isolated from clinical specimens of human intestinal origin","volume":"43","author":"Song","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1099\/ijs.0.64192-0","article-title":"Reclassification of Bacteroides distasonis, Bacteroides goldsteinii and Bacteroides merdae as Parabacteroides distasonis gen. Nov., comb. nov., Parabacteroides goldsteinii comb. nov. and Parabacteroides merdae comb. nov","volume":"56","author":"Sakamoto","year":"2006","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1136\/gutjnl-2017-315458","article-title":"Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis","volume":"68","author":"Wu","year":"2019","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1136\/gutjnl-2020-322599","article-title":"Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide","volume":"71","author":"Lai","year":"2022","journal-title":"Gut"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.anaerobe.2010.01.001","article-title":"First report of Parabacteroides goldsteinii bacteraemia in a patient with complicated intra-abdominal infection","volume":"16","author":"Awadel-Kariem","year":"2010","journal-title":"Anaerobe"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.idnow.2021.04.004","article-title":"Parabacteroides goldsteinii abdominal infection in a patient with lymphoma","volume":"52","author":"Cobo","year":"2022","journal-title":"Infect Dis Now"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3389\/fpubh.2020.00326","article-title":"Diversity of vaginal microbiome in pregnancy: deciphering the obscurity","volume":"8","author":"Gupta","year":"2020","journal-title":"Front Public Health"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1450931\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T04:39:44Z","timestamp":1723178384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1450931\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":7,"alternative-id":["10.3389\/fmed.2024.1450931"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1450931","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]},"article-number":"1450931"}}