{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:30:52Z","timestamp":1758267052323,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>A 40-year-old woman visited our clinic for recurred pterygium and symblepharon in the right eye. She had a history of pterygium excision 8 years before. Over the course of 7 years, we performed pterygium excision combined initially with mitomycin C (MMC) application and conjunctival autograft. This was followed by three procedures using limbal allografts, MMC application, and amniotic membrane transplantation. All procedures were unsuccessful, resulting in aggressive recurrences of pterygial mass and symblepharon, extraocular movement limitation, corneal astigmatism, and decreased visual acuity. Ultimately, we applied a labial mucosal autograft after the recession of pterygial tissue. No complications were observed. Two and a half years postoperatively, the labial mucosal autograft was well-integrated into the conjunctival surface without symblepharon recurrence or abduction limitation. Corneal clarity was restored, and astigmatism was reduced, with no recurrence of pterygium. In conclusion, a labial mucosal autograft is a viable treatment option in complex cases of recalcitrantly recurrent pterygium with symblepharon.<\/jats:p>","DOI":"10.3389\/fmed.2024.1452579","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T05:07:18Z","timestamp":1729660038000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Superior outcome of labial mucosal autograft over limbal allograft in the management of recurrent pterygium with symblepharon: a case report"],"prefix":"10.3389","volume":"11","author":[{"given":"Joo Youn","family":"Oh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang In","family":"Khwarg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/ICO.0000000000003422","article-title":"Risk factors for recurrence in the treatment of recurrent pterygium","volume":"43","author":"Kusano","year":"2024","journal-title":"Cornea."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1001\/archopht.1997.01100160405001","article-title":"Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision","volume":"115","author":"Tan","year":"1997","journal-title":"Arch Ophthalmol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4314\/ahs.v14i1.11","article-title":"Young patient's age determines pterygium recurrence after surgery","volume":"14","author":"Anguria","year":"2014","journal-title":"Afr Health Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"CD011349","DOI":"10.1002\/14651858.CD011349.pub2","article-title":"Conjunctival autograft for pterygium","volume":"2","author":"Clearfield","year":"2016","journal-title":"Cochr Database Syst Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3341\/jkos.2015.56.6.856","article-title":"Surgical outcome of primary pterygium excision with conjunctival autograft","volume":"56","author":"Kim","year":"2015","journal-title":"J Korean Ophthalmol Soc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1016\/S0161-6420(85)33831-9","article-title":"Conjunctival autograft transplantation for advanced and recurrent pterygium","volume":"92","author":"Kenyon","year":"1985","journal-title":"Ophthalmology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1016\/S0161-6420(02)01160-0","article-title":"Limbal versus conjunctival autograft transplantation for advanced and recurrent pterygium","volume":"109","author":"Al","year":"2002","journal-title":"Ophthalmology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1097\/ICO.0b013e3182a73a48","article-title":"A comparison of anchored conjunctival rotation flap and conjunctival autograft techniques in pterygium surgery","volume":"32","author":"Kim","year":"2013","journal-title":"Cornea."},{"key":"B9","doi-asserted-by":"publisher","first-page":"209401","DOI":"10.1155\/2013\/209401","article-title":"Comparison of wide conjunctival flap and conjunctival autografting techniques in pterygium surgery","volume":"2013","author":"Aslan","year":"2013","journal-title":"J Ophthalmol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.ophtha.2005.01.037","article-title":"Limbal allograft, amniotic membrane transplantation, and intraoperative mitomycin C for recurrent pterygium","volume":"112","author":"Miyai","year":"2005","journal-title":"Ophthalmology."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1007\/s00417-016-3483-y","article-title":"Long-term follow-up of transplantation of preserved limbal allograft and amniotic membrane for recurrent pterygium","volume":"254","author":"Ono","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000351631","article-title":"Oral mucosal grafts: old technique in new light","volume":"50","author":"Mai","year":"2013","journal-title":"Ophthalmic Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3109\/02713689408999878","article-title":"Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells","volume":"13","author":"Dushku","year":"1994","journal-title":"Curr Eye Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1080\/01676830.2018.1435693","article-title":"Oral mucosa grafting in periorbital reconstruction","volume":"37","author":"Grixti","year":"2018","journal-title":"Orbit."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e000337","DOI":"10.1136\/bmjophth-2019-000337","article-title":"Assessing full thickness oral mucosal grafting: complications and postoperative outcomes in a broad collective of patients","volume":"5","author":"Pilger","year":"2020","journal-title":"BMJ Open Ophthalmol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1452579\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T05:07:20Z","timestamp":1729660040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1452579\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":15,"alternative-id":["10.3389\/fmed.2024.1452579"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1452579","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2024,10,23]]},"article-number":"1452579"}}