{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:17:21Z","timestamp":1782742641636,"version":"3.54.5"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504800"],"award-info":[{"award-number":["2022YFC2504800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>In-58, a peptide derived from indolicidin, shows extraordinary antibacterial activity and lower toxicity than indolicidin toward mammalian cells. Here, we investigated the antifungal activity of In-58 against the human pathogen <jats:italic>Sporothrix globosa in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. In-58 markedly inhibited the growth of <jats:italic>Sporothrix globosa<\/jats:italic> isolates in microdilution assays and showed no antagonism with any tested antifungal agent (itraconazole, terbinafine or amphotericin B). Scanning electron microscopy and propidium iodide staining indicated that In-58 alters the cell wall integrity and interacts with DNA, leading to disruption of <jats:italic>S. globosa<\/jats:italic> in a dose-dependent manner. In <jats:italic>S. globosa<\/jats:italic>, the mitochondrial membrane potential decreased and reactive oxygen species increased after treatment with In-58. <jats:italic>In vivo<\/jats:italic> experiments in the <jats:italic>Galleria mellonella<\/jats:italic> (greater wax moth) larval infection model revealed the effectiveness of In-58 against <jats:italic>S. globosa<\/jats:italic> infection with low toxicity. Our results indicate that In-58 possesses remarkable antifungal activity against <jats:italic>S. globosa in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. It has potential as a novel drug for the treatment of sporotrichosis.<\/jats:p>","DOI":"10.3389\/fmed.2024.1458951","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T05:05:46Z","timestamp":1726117546000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Antifungal activity of indolicidin-derived peptide In-58 against Sporothrix globosa in vitro and in 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