{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:53:28Z","timestamp":1793386408718,"version":"4.5.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Constrictive bronchiolitis is a rare and severe condition characterized by progressive and irreversible obstruction of small airways. Constrictive bronchiolitis could be part of paraneoplastic autoimmune multiorgan syndrome secondary to Castleman disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case description<\/jats:title><jats:p>A 20-year-old female presented with progressive exertional dyspnea and severe obstructive ventilatory dysfunction. She also experienced recurrent and painful oral mucosal erosions. Upon investigation for underlying conditions, contrast-enhanced CT imaging revealed a pelvic mass exhibiting marked enhancement and hypertrophied vessels. A diagnosis of Castleman disease was confirmed via ultrasound-guided percutaneous biopsy of the pelvic tumor. Autoantibodies indicative of paraneoplastic pemphigus were detected using indirect immunofluorescence on rat bladder tissue. Complete surgical resection of the pelvic mass was undertaken with the collaborative efforts of a multidisciplinary team. Despite resolution of mucocutaneous lesions, symptoms of constrictive bronchiolitis persisted after the surgery. Subsequently, the patient underwent lung transplantation and demonstrated significant improvement in lung function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Timely diagnosis and comprehensive multidisciplinary management of this rare and life-threatening syndrome are crucial for enhancing patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1468251","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T04:31:56Z","timestamp":1728966716000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Constrictive bronchiolitis and paraneoplastic pemphigus caused by unicentric Castleman disease in a young woman: a case report"],"prefix":"10.3389","volume":"11","author":[{"given":"Ruxuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqun","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinbo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"6039","DOI":"10.1182\/bloodadvances.2020003334","article-title":"International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease","volume":"4","author":"van Rhee","year":"2020","journal-title":"Blood Adv"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41572-021-00317-7","article-title":"Castleman disease","volume":"7","author":"Carbone","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1056\/NEJMra1204664","article-title":"Obliterative bronchiolitis","volume":"370","author":"Barker","year":"2014","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1183\/2312508X.10003823","article-title":"Bronchiolitis","volume-title":"Rare diseases of the respiratory system (ERS monograph)","author":"Poletti","year":"2023"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1378\/chest.09-0800","article-title":"Bronchiolar disorders: a clinical-radiological diagnostic algorithm","volume":"137","author":"Devakonda","year":"2010","journal-title":"Chest"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaad.2023.08.020","article-title":"Paraneoplastic pemphigus\/paraneoplastic autoimmune multiorgan syndrome: part I. Clinical overview and pathophysiology","volume":"91","author":"Anderson","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1016\/j.jaad.2018.03.043","article-title":"Risk factors for death and survival in paraneoplastic pemphigus associated with hematologic malignancies in adults","volume":"80","author":"Ouedraogo","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.3389\/fimmu.2019.01259","article-title":"Paraneoplastic pemphigus: paraneoplastic autoimmune disease of the skin and mucosa","volume":"10","author":"Kim","year":"2019","journal-title":"Front Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1590\/abd1806-4841.20199165","article-title":"Paraneoplastic pemphigus: a clinical, laboratorial, and therapeutic overview","volume":"94","author":"Maruta","year":"2019","journal-title":"An Bras Dermatol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1046\/j.1365-2133.2002.04992.x","article-title":"Paraneoplastic pemphigus in children and adolescents","volume":"147","author":"Mimouni","year":"2002","journal-title":"Br J Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s40644-019-0238-0","article-title":"Imaging and clinical features of Castleman disease","volume":"19","author":"Zhao","year":"2019","journal-title":"Cancer Imaging"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"100720","DOI":"10.1016\/j.lanwpc.2023.100720","article-title":"A national, multicenter, retrospective study of Castleman disease in China implementing CDCN criteria","volume":"34","author":"Zhang","year":"2023","journal-title":"Lancet Reg Health West Pac"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e14496","DOI":"10.1111\/ctr.14496","article-title":"Bilateral lung transplantation for Castleman disease with end-stage bronchiolitis obliterans","volume":"36","author":"Yue","year":"2022","journal-title":"Clin Transpl"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00432-010-0874-z","article-title":"Improved outcomes after complete resection of underlying tumors for patients with paraneoplastic pemphigus: a single-center experience of 22 cases","volume":"137","author":"Zhang","year":"2011","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"304","DOI":"10.21037\/hbsn.2019.05.05","article-title":"Retrospective analysis of 45 cases of localized retroperitoneal Castleman disease from a single center","volume":"9","author":"Tang","year":"2020","journal-title":"Hepatobiliary Surg Nutr"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1468251\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T04:31:57Z","timestamp":1728966717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1468251\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":15,"alternative-id":["10.3389\/fmed.2024.1468251"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1468251","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,15]]},"article-number":"1468251"}}