{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:24:34Z","timestamp":1771565074733,"version":"3.50.1"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neurodermatitis is a chronic skin condition characterized by intense itching and skin thickening due to neurological dysfunction. Its persistent nature poses a challenge to effective treatment, significantly impacting patients\u2019 quality of life. Wet cupping therapy is increasingly being used in clinics to manage neurodermatitis, so it is imperative to assess the evidence regarding its effectiveness and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This review aimed to evaluate the efficacy and safety of wet cupping therapy in patients with neurodermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>Randomized controlled trials (RCTs) investigating wet cupping for neurodermatitis were identified through searches of eight electronic databases and three clinical trial registration platforms from inception to March 2024, using predefined search terms. Included studies underwent quality appraisal using the Cochrane Collaboration\u2019s Risk of Bias Assessment tool. The quality of evidence was assessed independently by two reviewers using the Grading of Recommendations Assessment, Development, and Evaluation System (GRADE). Meta-analysis and publication bias assessment were conducted using ReviewManager 5.4 and STATA 17.0 software, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This review encompassed 19 studies, comprising 6 types of comparisons and involving 1,505 participants. The findings revealed no significant difference in the total effective rate between wet cupping alone and high-potency steroids (<jats:italic>n<\/jats:italic>\u202f=\u202f269, RR\u202f=\u202f1.13, 95% CI [0.90, 1.41], <jats:italic>p<\/jats:italic>\u202f=\u202f0.29, I<jats:sup>2<\/jats:sup>\u202f=\u202f83%). However, wet cupping combined with medication or moxibustion exhibited superior efficacy compared to medication alone (<jats:italic>n<\/jats:italic>\u202f=\u202f272, RR\u202f=\u202f1.28, 95% CI [1.16, 1.41], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.00001, I<jats:sup>2<\/jats:sup>\u202f=\u202f43%) and (<jats:italic>n<\/jats:italic>\u202f=\u202f534, RR\u202f=\u202f1.22, 95% CI [1.14, 1.30], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.00001, I<jats:sup>2<\/jats:sup>\u202f=\u202f0%). Wet cupping groups demonstrated lower recurrence rates (<jats:italic>n<\/jats:italic>\u202f=\u202f266, RR\u202f=\u202f0.31, 95% CI [0.16, 0.60], <jats:italic>p<\/jats:italic>\u202f=\u202f0.0005, I<jats:sup>2<\/jats:sup>\u202f=\u202f0%) and a reduced incidence of adverse events (<jats:italic>n<\/jats:italic>\u202f=\u202f673, RR\u202f=\u202f0.44, 95% CI [0.21, 0.90], <jats:italic>p<\/jats:italic>\u202f=\u202f0.02, I<jats:sup>2<\/jats:sup>\u202f=\u202f36%). Furthermore, wet cupping alone or combined with moxibustion effectively lowered the levels of inflammatory factors compared to medication: TNF-<jats:italic>\u03b1<\/jats:italic> (<jats:italic>n<\/jats:italic>\u202f=\u202f120, MD\u202f=\u202f\u22126.99, 95% CI [\u22128.13, \u22125.85], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.00001, I<jats:sup>2<\/jats:sup>\u202f=\u202f0%), IL-1\u03b2 (<jats:italic>n<\/jats:italic>\u202f=\u202f120, MD\u202f=\u202f\u22125.28, 95% CI [\u22126.91, \u22123.65], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.00001, I<jats:sup>2<\/jats:sup>\u202f=\u202f48%), and IL-6 (<jats:italic>n<\/jats:italic>\u202f=\u202f180, MD\u202f=\u202f\u22128.61, 95% CI [\u221213.24, \u22123.99], <jats:italic>p<\/jats:italic>\u202f=\u202f0.0003, I<jats:sup>2<\/jats:sup>\u202f=\u202f81%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The efficacy of wet cupping therapy is comparable to that of high-potency steroids. Its combined use with medication or moxibustion appears to enhance effectiveness, reduce recurrence rates, and improve safety. However, due to the overall low grade of evidence for the identified outcomes and poor methodological quality, caution is advised when interpreting and applying these findings in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:uri>https:\/\/www.crd.york.ac.uk\/prospero<\/jats:uri>, identifier: CRD42024524398.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1478073","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T06:25:43Z","timestamp":1734589543000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of wet cupping in the treatment of neurodermatitis: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Yan","family":"Zhai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-yi","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-fei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1111\/j.1610-0387.2009.06972.x","article-title":"Atopic dermatitis: S2 guidelines","volume":"7","author":"Werfel","year":"2009","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology: JDDG"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.it.2018.10.001","article-title":"The itch\u2013scratch cycle: a Neuroimmune perspective","volume":"39","author":"Mack","year":"2018","journal-title":"Trends Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.2340\/00015555-3296","article-title":"Skin barrier damage and itch: review of mechanisms, topical management and future directions","volume":"99","author":"Yosipovitch","year":"2019","journal-title":"Acta Derm Venereol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.12290\/xhyxzz.2021-0747","article-title":"Research and therapy Progress on the mechanisms of pruritus in atopic dermatitis","volume":"13","author":"Tang","year":"2022","journal-title":"Med 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cupping and mild moxibustion in the treatment of localized neurodermatitis","volume":"2","author":"Li","year":"2007","journal-title":"J Pract Hosp Clin"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"289","DOI":"10.13633\/j.cnki.zjtcm.2017.04.045","article-title":"Observation on the efficacy of plum blossom needle combined with cupping in the treatment of 75 cases of neurodermatitis","volume":"52","author":"Lin","year":"2017","journal-title":"Zhejiang J Trad Chin Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3969\/j.issn.1671-3141.2021.87.058","article-title":"Observation on the efficacy of pricking and cupping therapy combined with compound clobetasol propionate ointment in the treatment of neurodermatitis","volume":"21","author":"Li","year":"2021","journal-title":"World Latest Med Inform"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3969\/j.issn.1671-7813.2012.10.42","article-title":"Randomized controlled clinical study of plum blossom needle combined with cupping in the treatment of localized neurodermatitis. Journal of practical traditional Chinese","volume":"26","author":"Zhang","year":"2012","journal-title":"Intern Med"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.16588\/j.cnki.issn1002-1108.1998.02.027","article-title":"A report of 60 cases of neurodermatitis treated with three-step method of seven-star needle","volume":"2","author":"Huang","year":"1998","journal-title":"J Guiyang Coll Trad Chin Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3760\/cma.j.cn115689-20230712-02580","article-title":"Therapeutic effect of pricking and cupping combined with fumigation and moxibustion on localized neurodermatitis","volume":"50","author":"Ren","year":"2023","journal-title":"Chin J Pract Med"},{"key":"ref48","first-page":"49","article-title":"Clinical analysis of 182 patients with neurodermatitis and its relationship with nerve anxiety","volume":"18","author":"Meng","year":"2015","journal-title":"Chin J Pract Nervous Dis"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"64","DOI":"10.13359\/j.cnki.gzxbtcm.2020.01.012","article-title":"Analysis of the effect of walking cupping method on serum tumor necrosis factor \u03b1 and vascular endothelial growth factor levels in patients with psoriasis vulgaris and blood stasis syndrome and its clinical efficacy","volume":"37","author":"He","year":"2020","journal-title":"J Guangzhou Univ Trad Chin Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"811","DOI":"10.13683\/j.wph.2019.11.012","article-title":"Research progress of acupuncture and cupping therapy in the treatment of psoriasis vulgaris","volume":"40","author":"Li","year":"2019","journal-title":"World Clin Drug"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"419","DOI":"10.19945\/j.cnki.issn.1006-3250.2014.03.061","article-title":"Research progress on acupuncture treatment of skin pruritus","volume":"20","author":"Wang","year":"2014","journal-title":"J Basic Chin Med"},{"key":"ref52","first-page":"48","article-title":"Effects of electroacupuncture on the content of inflammatory mediators in the inflammatory area of rats with adjuvant arthritis","volume":"1","author":"Yang","year":"1999","journal-title":"J Chengdu Univ Trad Chin Med"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"548","DOI":"10.14148\/j.issn.1672-0482.2016.0548","article-title":"Effects of fire needle on JNK and p 38 mitogen-activated protein kinase in ankle joints of rats with rheumatoid arthritis","volume":"32","author":"Shen","year":"2016","journal-title":"J Nanjing Univ Chin Med"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"125","DOI":"10.15909\/j.cnki.cn61-1347\/r.004363","article-title":"Effects of fire acupuncture combined with Halomethasone ointment on symptom score and serum inflammatory factors in patients with Neurodermatitis","volume":"30","author":"Zhao","year":"2021","journal-title":"Chinese J Aesth Med"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.steroids.2017.07.007","article-title":"Inflammation regulates 11\u03b2-hydroxysteroid dehydrogenase type 1 differentially in specific compartments of the gut mucosal immune system\u2014science direct","volume":"126","author":"Ergang","year":"2017","journal-title":"Steroids"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3390\/ijms25010236","article-title":"Key factors in the complex and coordinated network of skin keratinization: their significance and involvement in common skin conditions","volume":"25","author":"Pondeljak","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/964069","article-title":"IL-6 as a Druggable target in psoriasis: focus on pustular variants","volume":"2014","author":"Saggini","year":"2014","journal-title":"J Immunol Res"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"11662","DOI":"10.3390\/ijms241411662","article-title":"Inflammatory cytokines in psoriatic arthritis: understanding pathogenesis and implications for treatment","volume":"24","author":"Lee","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jgr.2016.02.003","article-title":"Korean red ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro","volume":"41","author":"Kee","year":"2017","journal-title":"J Ginseng Res"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"9","DOI":"10.14164\/j.cnki.cn11-5581\/r.2017.24.004","article-title":"Clinical observation of tazarotene gel combined with compound flumetasone ointment in the treatment of 62 patients with local neurodermatitis","volume":"11","author":"Long","year":"2017","journal-title":"Chin J Modern 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