{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:01:56Z","timestamp":1753891316731,"version":"3.41.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100632"],"award-info":[{"award-number":["82100632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Patients with inflammatory bowel disease (IBD) are at risk of developing malnutrition, severe dystrophic muscle weakness, and muscle atrophy. We present a case of a 33-year-old male patient who exhibited concurrent muscle atrophy, muscle weakness, diarrhea, and mucopurulent bloody stools. Notably, the patient reported that his household or family members experienced similar symptoms of muscle weakness, without any apparent neurological or psychiatric manifestations. The patient\u2019s intestinal symptoms were most consistent with ulcerative colitis, while the muscle weakness originated from dysferlinopathy following a comprehensive diagnostic work-up. The patient was initiated on vedolizumab therapy and L-carnitine therapy, and his symptoms improved after 1\u202fmonth of follow-up. This case study underscores the necessity for clinicians to maintain a high level of suspicion for the presence of concomitant diseases when encountering IBD patients with muscle weakness. This approach is essential for achieving an early diagnosis and treatment.<\/jats:p>","DOI":"10.3389\/fmed.2024.1481780","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T07:17:15Z","timestamp":1737530235000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: A co-existing case of ulcerative colitis and dysferlinopathy in a male patient"],"prefix":"10.3389","volume":"11","author":[{"given":"Limin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhan","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiejun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nrgastro.2012.152","article-title":"The gut microbiota in IBD","volume":"9","author":"Manichanh","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","article-title":"Gut microbiota and IBD: causation or correlation?","volume":"14","author":"Ni","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1001\/jamapediatrics.2015.1982","article-title":"Inflammatory bowel disease in children and adolescents","volume":"169","author":"Rosen","year":"2015","journal-title":"JAMA Pediatr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1001\/jama.2023.23814","article-title":"What is ulcerative colitis?","volume":"331","author":"Voelker","year":"2024","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12920-022-01284-y","article-title":"Dysferlinopathy misdiagnosed with juvenile polymyositis in the pre-symptomatic stage of hyper CKemia: a case report and literature review","volume":"15","author":"Contreras-Cubas","year":"2022","journal-title":"BMC Med Genet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.nmd.2018.05.007","article-title":"229th ENMC international workshop: limb girdle muscular dystrophies\u2014nomenclature and reformed classification Naarden, the Netherlands, 17\u201319 March 2017","volume":"28","author":"Straub","year":"2018","journal-title":"Neuromuscul Disord"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/mus.25367","article-title":"Progress and challenges in diagnosis of dysferlinopathy","volume":"54","author":"Fanin","year":"2016","journal-title":"Muscle Nerve"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3390\/nu13020656","article-title":"Sarcopenia in inflammatory bowel disease: a narrative overview","volume":"13","author":"Dhaliwal","year":"2021","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"8646495","DOI":"10.1155\/2017\/8646495","article-title":"Nutrition and IBD: malnutrition and\/or sarcopenia? A practical guide","volume":"2017","author":"Scaldaferri","year":"2017","journal-title":"Gastroenterol Res Pract"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.crohns.2013.11.006","article-title":"Lower extremity mobility limitation and impaired muscle function in women with ulcerative colitis","volume":"8","author":"Zaltman","year":"2014","journal-title":"J Crohns Colitis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"5668","DOI":"10.3748\/wjg.v29.i41.5668","article-title":"Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity: the \u201cBE-FIT-IBD\u201d study","volume":"29","author":"Gravina","year":"2023","journal-title":"World J Gastroenterol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.nmd.2014.06.434","article-title":"Two patients with co-morbid myasthenia gravis in a Brazilian cohort of inflammatory bowel disease","volume":"24","author":"Gondim Fde","year":"2014","journal-title":"Neuromuscul Disord"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.arcped.2014.10.014","article-title":"Unusual association of myasthenia gravis and ulcerative colitis in a 14-year-old boy","volume":"22","author":"Guinet-Charpentier","year":"2015","journal-title":"Arch Pediatr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1016\/j.athoracsur.2016.09.077","article-title":"Myasthenia gravis, mediastinal goiter, and Crohn\u2019s disease","volume":"103","author":"Rocha","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1136\/gut.35.2.278","article-title":"Crohn\u2019s disease and myasthenia gravis: a possible role for thymectomy","volume":"35","author":"Finnie","year":"1994","journal-title":"Gut"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.3389\/fimmu.2020.01688","article-title":"Editorial: Advances in autoimmune myasthenia gravis","volume":"11","author":"Punga","year":"2020","journal-title":"Front Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S1474-4422(09)70063-8","article-title":"Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity","volume":"8","author":"Meriggioli","year":"2009","journal-title":"Lancet Neurol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1481780\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T07:17:18Z","timestamp":1737530238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1481780\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":17,"alternative-id":["10.3389\/fmed.2024.1481780"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1481780","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"article-number":"1481780"}}