{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:28:06Z","timestamp":1789140486591,"version":"build-2803163510"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy of probiotics and early oral feeding in patients with severe acute pancreatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective, randomized, controlled trial was conducted involving 66 patients, who were randomly divided into a control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f32) receiving standard enteral nutrition and an observation group (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f34) receiving additional Bifidobacterium quadruplex live bacterial tablets. Serum inflammatory markers, including white blood cells (WBC), interleukin-6 (IL-6), tumor necrosis factor-\n                      <jats:italic>\u03b1<\/jats:italic>\n                      (TNF-\u03b1), and C-reactive protein (CRP), were measured on days 1, 3, and 7 post-admission. Abdominal pain scores, the computed tomography severity index (CTSI), and the Bedside Index for Severity in Acute Pancreatitis (BISAP) scores were also assessed. Additionally, defecation time and the total duration of hospitalization were compared between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Inflammatory markers declined in all groups by the third day post-admission, with the observation group exhibiting a significantly greater reduction compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Similarly, from the first day to the third day, both groups experienced a decrease in abdominal pain scores, CTSI, and BISAP scores, with the observation group showing a significantly more pronounced decrease in BISAP scores compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). By the seventh day of admission, inflammatory markers continued to decline in all groups compared to the third day, except for TNF-\n                      <jats:italic>\u03b1<\/jats:italic>\n                      levels, and the observation group demonstrated a significantly greater decrease compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Abdominal pain scores, CTSI, and BISAP scores also decreased further in both groups compared to the third day, with the observation group again showing a significantly greater improvement than the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Additionally, the observation group had a significantly shorter time to bowel movement resumption (38.23\u202f\u00b1\u202f2.31\u202fh vs. 43.43\u202f\u00b1\u202f2.75\u202fh,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.013) and total hospital stay compared to the control group (10.97\u202f\u00b1\u202f0.35\u202fdays vs. 13.40\u202f\u00b1\u202f0.50\u202fdays,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early oral ingestion combined with probiotics can reduce the levels of inflammatory factors, improve abdominal pain symptoms, alleviate pancreatic edema and shorten defecation time and hospital stay in patients with severe acute pancreatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2024.1492108","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T23:22:12Z","timestamp":1733181732000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Observation on the therapeutic effect of probiotics on early oral feeding in the treatment of severe acute pancreatitis"],"prefix":"10.3389","volume":"11","author":[{"given":"Yanan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.3748\/wjg.v28.i33.4926","article-title":"Prediction of moderately severe and severe acute pancreatitis in pregnancy: several issues","volume":"28","author":"Yang","year":"2022","journal-title":"World J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/s12664-019-00962-7","article-title":"Efficacy of enteral glutamine supplementation in patients with severe and predicted severe acute pancreatitis- a randomized controlled trial","volume":"38","author":"Arutla","year":"2019","journal-title":"Indian J Gastroenterol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12934-020-1289-4","article-title":"Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier","volume":"19","author":"Liu","year":"2020","journal-title":"Microb Cell Factories"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"578","DOI":"10.3760\/cma.j.cn112139-20210416-00172","article-title":"Chinese Pancreatic Surgery Association, Chinese Society of Surgery Chinese Medical Association. Guidelines for diagnosis and treatment of acute pancreatitis in China","volume":"59","year":"2021","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.joim.2023.10.004","article-title":"Electroacupuncture for abdominal pain relief in patients with acute pancreatitis: a three-arm randomized controlled trial","volume":"21","author":"Kee Jang","year":"2023","journal-title":"J Integr Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/1751-2980.12961","article-title":"Evaluation of the modified computed tomography severity index (MCTSI) and computed tomography severity index (CTSI) in predicting severity and clinical outcomes in acute pancreatitis","volume":"22","author":"Alberti","year":"2021","journal-title":"J Dig Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.47391\/JPMA.03-417","article-title":"Bedside index (BISAP) v\/s Ranson scores in predicting mortality and severity in patients with acute pancreatitis","volume":"71","author":"Kapadia","year":"2021","journal-title":"J Pak Med Assoc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1097\/CCM.0000000000003152","article-title":"Early enteral nutrition provided within 24 hours of ICU admission: a Meta-analysis of randomized controlled trials","volume":"46","author":"Tian","year":"2018","journal-title":"Crit Care Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"110770","DOI":"10.1016\/j.biopha.2020.110770","article-title":"Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: a troublesome trio for acute pancreatitis","volume":"132","author":"Ge","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e08852","DOI":"10.1016\/j.heliyon.2022.e08852","article-title":"Immediate enteral nutrition can accelerate recovery and be safe in mild acute pancreatitis: a meta-analysis of randomized controlled trials","volume":"8","author":"Guo","year":"2022","journal-title":"Heliyon"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1177\/0148607112440823","article-title":"International consensus guidelines for nutrition therapy in pancreatitis","volume":"36","author":"Mirtallo","year":"2012","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"907","DOI":"10.5152\/tjg.2021.201033","article-title":"Effect of early enteral nutrition on serum inflammatory factors and intestinal mucosal permeability in patients with severe acute pancreatitis","volume":"32","author":"Li","year":"2021","journal-title":"Turk J Gastroenterol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.21037\/apm-21-429","article-title":"The role of gut microbiota in the pathogenesis and treatment of acute pancreatitis: a narrative review","volume":"10","author":"Lu","year":"2021","journal-title":"Ann Palliat Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.pan.2021.11.009","article-title":"Effects of immediate or early oral feeding on acute pancreatitis: a systematic review and meta-analysis","volume":"22","author":"Yao","year":"2022","journal-title":"Pancreatology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"96","DOI":"10.29271\/jcpsp.2020.01.96","article-title":"Efficacy of Microecopharmaceutics combined with early enteral nutrition support in the treatment of severe acute pancreatitis","volume":"30","author":"Qiu","year":"2020","journal-title":"J Coll Physicians Surg Pak"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3969\/j.issn.1002-1949.2021.05.016","article-title":"Research progress of intestinal flora in severe acute pancreatitis","volume":"41","author":"Ayijiang","year":"2021","journal-title":"Chin J Crit Care"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1097\/MPA.0000000000000355","article-title":"Dysbiosis of intestinal microbiota associated with inflammation involved in the progression of acute pancreatitis","volume":"44","author":"Tan","year":"2015","journal-title":"Pancreas"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/MEG.0000000000002124","article-title":"Bacterial infections in acute pancreatitis","volume":"33","author":"Marstrand-Joergensen","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s00268-001-0146-9","article-title":"Characteristics of infection with Candida species in patients with necrotizing pancreatitis","volume":"26","author":"Isenmann","year":"2002","journal-title":"World J Surg"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1016\/S0002-9270(99)00808-4","article-title":"The effects of antibiotic use on gastrointestinal function","volume":"95","author":"Levy","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3109\/00365521.2010.531486","article-title":"Systematic review and meta-analysis of antibiotic prophylaxis in severe acute pancreatitis","volume":"46","author":"Wittau","year":"2011","journal-title":"Scand J Gastroenterol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"690","DOI":"10.3389\/fphar.2018.00690","article-title":"Supplemented use of pre-, pro-, and Synbiotics in severe acute pancreatitis: an updated systematic review and Meta-analysis of 13 randomized controlled trials","volume":"9","author":"Tian","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0140-6736(08)60207-X","article-title":"Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial","volume":"371","author":"Besselink","year":"2008","journal-title":"Lancet"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: a review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1007\/s00268-022-06844-y","article-title":"Impact of early enteral nutrition on delayed gastric emptying and nutritional status after Pancreaticoduodenectomy","volume":"47","author":"Hosoda","year":"2023","journal-title":"World J Surg"},{"key":"ref26","first-page":"2261","article-title":"Effect of ecological immune-enhanced enteral nutrition on patients with gastrointestinal fistulas","volume":"21","author":"Wang","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref27","first-page":"1185","article-title":"Effects of Bifidobacterium tetragenous viable bacteria tablets on gut microbiota in6 non-alcoholic fatty liver disease patients based on high-throughput sequencing","volume":"33","author":"Wei","year":"2024","journal-title":"Chin J Gastroenterol Hepatol"},{"key":"ref28","first-page":"185","article-title":"The changes of gut microbiota in patients with constipation-predominant irritable bowel syndrome and efficacy of Bifidobacterium Tetravaccine tablets","volume":"36","author":"Wang","year":"2024","journal-title":"Chinese J Microecol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/1751-2980.13138","article-title":"Effects of probiotics on gastric microbiota and its precombination with quadruple regimen for Helicobacter pylori eradication","volume":"23","author":"Wu","year":"2022","journal-title":"J Dig Dis"},{"key":"ref30","first-page":"74","volume-title":"Ketorolac and predicted severe acute pancreatitis: A randomized, controlled clinical trialClin Med Res","author":"Shahbazi","year":"2020"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3748\/wjg.v27.i2.224","article-title":"Effect of probiotics on length of hospitalization in mild acute pancreatitis: a randomized, double-blind, placebo-controlled trial","volume":"27","author":"Wan","year":"2021","journal-title":"World J Gastroenterol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1492108\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T23:22:17Z","timestamp":1733181737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1492108\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,3]]},"references-count":31,"alternative-id":["10.3389\/fmed.2024.1492108"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1492108","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,3]]},"article-number":"1492108"}}