{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:04:20Z","timestamp":1772114660909,"version":"3.50.1"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary artery pressure and vascular resistance, leading to systemic venous hypertension and potential right heart failure. These elevated pressures can extend to ocular veins, resulting in complications such as central retinal vein occlusion (CRVO). This case report highlights a rare instance of CRVO combined with cilioretinal artery occlusion (CilRAO), an uncommon ocular manifestation associated with PAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 13-year-old girl with a history of surgically repaired ventricular septal defect presented with sudden vision loss and a central visual field defect. Investigation confirmed CRVO and an unusual concurrent CilRAO. Although laboratory tests were inconclusive, the echocardiographic examination suggested severe pulmonary arterial hypertension (PAH). The patient received treatment with Bosentan and traditional Chinese medicine, which improved her vision to 20\/20, though a paracentral scotoma remained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case underscores the critical link between systemic cardiovascular abnormalities and ocular health in PAH, where elevated venous pressure can result in severe and distinctive ocular manifestations. The co-occurrence of CRVO and CilRAO in this patient highlights the susceptibility of cilioretinal arteries to hemodynamic changes, as these arteries lack autoregulatory capacity. Additionally, this case demonstrates the potential for positive outcomes in ocular lesions with targeted PAH therapy. Importantly, it emphasizes the need for vigilance when managing complex cases where conclusions cannot be drawn solely from ocular findings. A multidisciplinary approach and comprehensive diagnostics are essential for identifying underlying causes, ensuring active treatment, and preventing permanent vision loss and serious systemic complications.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1493834","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:29:12Z","timestamp":1734676152000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case report: Cilioretinal artery occlusion combined with central retinal vein occlusion as the initial presentation of pulmonary arterial hypertension"],"prefix":"10.3389","volume":"11","author":[{"given":"Yane","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingshuai","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1136\/heartjnl-2018-314025","article-title":"Assessment of reversibility in pulmonary arterial hypertension and congenital heart disease","volume":"105","author":"van der Feen","year":"2019","journal-title":"Heart"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e23476","DOI":"10.7759\/cureus.23476","article-title":"Spontaneous visual acuity recovery after Cilioretinal artery occlusion combined with central retinal vein occlusion in a young patient","volume":"14","author":"Markakis","year":"2022","journal-title":"Cureus"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2147\/IMCRJ.S96858","article-title":"Preservation of retinal structure and function after cilioretinal artery occlusion: a case report","author":"Brown","year":"2016","journal-title":"IMCRJ"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1097\/IAE.0b013e31815ec29b","article-title":"Central retinal vein occlusion associated with Cilioretinal artery 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Consensus statement from the congenital heart disease and pediatric task forces, pulmonary vascular research institute (PVRI)","volume":"4","author":"Lopes","year":"2014","journal-title":"Pulm Circ"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3928\/15428877-20090101-18","article-title":"Secondary open-angle Glaucoma and central retinal vein occlusion in a patient with primary pulmonary hypertension","volume":"40","author":"Senthil","year":"2009","journal-title":"Ophthalmic Surg Lasers Imaging Retina"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1493834\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:29:14Z","timestamp":1734676154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1493834\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":14,"alternative-id":["10.3389\/fmed.2024.1493834"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1493834","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"article-number":"1493834"}}