{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:52:57Z","timestamp":1773935577651,"version":"3.50.1"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the health-related quality of life (HRQoL) in ankylosing spondylitis (AS) patients in the Chaoshan region and identify factors influencing the ASAS Health Index (ASAS-HI) to enhance comprehensive AS treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A survey of ASAS-HI was conducted on 82 AS patients from the rheumatology outpatient department of the First Affiliated Hospital of Shantou University Medical College. The Bath Ankylosing Spondylitis Global Score (BAS-G) assessed overall health status, the Ankylosing Spondylitis Quality of Life Questionnaire (AS-QOL) evaluated quality of life, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) measured disease activity, and the Bath Ankylosing Spondylitis Functional Index (BASFI) assessed functional difficulties. Inflammatory markers and patient data were collected, and univariate\/multivariate logistic regression analyses were used to explore influencing factors of ASAS-HI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean ASAS-HI score was 3.52\u202f\u00b1\u202f3.12. ASAS-HI was positively correlated with BASDAI (<jats:italic>r<\/jats:italic>\u202f=\u202f0.478, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), ASDAS-CRP (<jats:italic>r<\/jats:italic>\u202f=\u202f0.406, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), BASFI (<jats:italic>r<\/jats:italic>\u202f=\u202f0.338, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.002), and BAS-G (<jats:italic>r<\/jats:italic>\u202f=\u202f0.335, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.002). Patients with ASDAS-ES<jats:italic>R<\/jats:italic> \u2265\u202f2.1, ASDAS-CRP\u202f\u2265\u202f2.1, and spinal tenderness had significantly higher ASAS-HI scores than others (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001). Spinal tenderness and radiographic grading were identified as key influencing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ASAS-HI is significantly impacted by disease activity and functional limitations. Early assessment of ASAS-HI is crucial for optimizing disease management in AS patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2024.1499798","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T06:16:44Z","timestamp":1736317004000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of ASAS health index and its influencing factors in ankylosing spondylitis: a prospective study based on the population of Chaoshan region"],"prefix":"10.3389","volume":"11","author":[{"given":"Aikang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongji","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangbin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/NOR.0000000000000938","article-title":"Ankylosing Spondylitis","volume":"42","author":"Graham","year":"2023","journal-title":"Orthop Nurs"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e0138492","DOI":"10.1371\/journal.pone.0138492","article-title":"Changes in the prevalence of rheumatic diseases in Shantou, China, in the Past Three Decades: A COPCORD Study","volume":"10","author":"Zeng","year":"2015","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41584-021-00625-y","article-title":"Ankylosing spondylitis: an autoimmune or autoinflammatory disease?","volume":"17","author":"Mauro","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"ref4","first-page":"S108","article-title":"Health-related quality of life in patients with rheumatoid arthritis and in patients with ankylosing spondylitis","volume":"27","author":"Kiltz","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-024-01912-x","article-title":"Association of the newly proposed dietary index for gut microbiota and depression: the mediation effect of phenotypic age and body mass index","author":"Zhang","year":"2024","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3109\/03009742.2016.1150506","article-title":"Clinical importance of inflammatory facet joints of the spine in ankylosing spondylitis: a magnetic resonance imaging study","volume":"45","author":"Lee","year":"2016","journal-title":"Scand J Rheumatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/acr.25267","article-title":"Relationships of work productivity and activity impairment with patient-reported outcomes in ankylosing spondylitis: results from two trials","volume":"76","author":"Magrey","year":"2024","journal-title":"Arthritis Care Res"},{"key":"ref8","first-page":"S-105-108","article-title":"The ASAS health index (ASAS HI) - a new tool to assess the health status of patients with spondyloarthritis","volume":"32","author":"Kiltz","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1136\/annrheumdis-2013-203967","article-title":"Development of a health index in patients with ankylosing spondylitis (ASAS HI): final result of a global initiative based on the ICF guided by ASAS","volume":"74","author":"Kiltz","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/ard.2010.133645","article-title":"The assessment of SpondyloArthritis international society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general","volume":"70","author":"Rudwaleit","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.3899\/jrheum.200025","article-title":"Performance of the ASAS health index for the evaluation of Spondyloarthritis in daily practice","volume":"47","author":"Alonso-Castro","year":"2020","journal-title":"J Rheumatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis. 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