{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:33:45Z","timestamp":1788878025088,"version":"build-2803163510"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a biphasic epithelial tumor associated with HPV infection. This rare tumor primarily affects the nasal cavity and paranasal sinuses, with only two cases reported outside these locations to date\u2014one in the breast and one in the vulva. This report presents a case of a tumor resembling an HMSC arising in the cervix. A 69-year-old female patient presented to our hospital with a history of vaginal bleeding lasting for more than a year. The patient tested positive for high-risk HPV. A cervical biopsy revealed high-grade squamous intraepithelial lesion with invasion. Subsequently, the patient underwent radical hysterectomy for cervical cancer. The postoperative pathological diagnosis, based on histology, immunohistochemistry, and HPV testing, was multiphenotypic cervical carcinoma resembling HMSC. The patient did not receive any adjuvant radiotherapy or chemotherapy postoperatively. Notably, during a year of postoperative follow-up, no recurrence or metastasis was observed. Multiphenotypic cervical carcinoma is a rare tumor that resembles HPV-related multiphenotypic sinonasal carcinoma. These tumors are associated with HPV infection, typically exhibit high-grade histological features, and show a propensity for local indolent progression clinically. Accurate identification of these tumors through their histological characteristics and immunohistochemical staining, followed by confirmation with HPV and molecular genetic testing, is crucial for precise diagnosis, prognostication, and effective management.<\/jats:p>","DOI":"10.3389\/fmed.2024.1507736","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T04:24:11Z","timestamp":1733372651000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case report: Multiphenotypic cervical cancer resembling human papillomavirus-related multiphenotypic sinonasal carcinoma"],"prefix":"10.3389","volume":"11","author":[{"given":"Xiaoxiao","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1097\/PAS.0b013e31827b1cd6","article-title":"Human papillomavirus-related carcinoma with adenoid cystic-like features: A peculiar variant of head and neck cancer restricted to the sinonasal tract.","volume":"37","author":"Bishop","year":"2013","journal-title":"Am J Surg Pathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1097\/PGP.0b013e31822103a1","article-title":"Adenoid basal carcinoma of the uterine cervix: Clinicopathologic features of 12 cases with reference to CD117 expression.","volume":"31","author":"Chen","year":"2012","journal-title":"Int J Gynecol Pathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/his.13968","article-title":"A clinicopathological and molecular analysis of cervical carcinomas with basaloid features.","volume":"76","author":"Shi","year":"2020","journal-title":"Histopathology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1177\/10668969221134691","article-title":"Adenoid basal carcinoma with adenoid cystic carcinoma component of the uterine cervix: A case report and literature review.","volume":"31","author":"Kitamura","year":"2023","journal-title":"Int J Surg Pathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/00000478-198802000-00007","article-title":"\u201cAdenoid cystic\u201d carcinoma and adenoid basal carcinoma of the uterine cervix. A study of 28 cases.","volume":"12","author":"Ferry","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s12105-018-0969-4","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma with unique HPV type 52 association: A case report with review of literature.","volume":"13","author":"Adamane","year":"2019","journal-title":"Head Neck Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1111\/his.13301","article-title":"Human papillomavirus-related carcinoma with adenoid cystic-like features: A series of five cases expanding the pathological spectrum.","volume":"71","author":"Hang","year":"2017","journal-title":"Histopathology."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-020-01050-7","article-title":"Sinonasal analogue HPV related breast multiphenotypic carcinoma: A report of a case with the first description in the breast.","volume":"15","author":"Oramas","year":"2020","journal-title":"Diagn Pathol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000001034","article-title":"Human papillomavirus-associated multiphenotypic carcinoma: First description of a vulval case.","author":"Currie","year":"2024","journal-title":"Int J Gynecol Pathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1177\/1066896921997132","article-title":"Basaloid squamous cell carcinoma of the uterine cervix: Report of a case with molecular analysis.","volume":"29","author":"Munkhdelger","year":"2021","journal-title":"Int J Surg Pathol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00795-023-00354-z","article-title":"A case of coexistent poorly differentiated adenosquamous carcinoma (glassy cell carcinoma), usual-type adenocarcinoma, and squamous cell carcinoma in situ of the cervix.","volume":"56","author":"Habara","year":"2023","journal-title":"Med Mol Morphol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56010037","article-title":"Mucoepidermoid carcinoma of the uterine cervix-single-center study over a 10-year period.","volume":"56","author":"Yordanov","year":"2020","journal-title":"Medicina (Kaunas)."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2023.108835","article-title":"Neuroendocrine carcinoma of the cervix: About a rare case and literature review.","volume":"111","author":"El Abbassi","year":"2023","journal-title":"Int J Surg Case Rep."},{"key":"B14","first-page":"2187","article-title":"The coexistence of invasive stratified mucin-producing carcinoma, mucinous carcinoma and non-specific type and squamous cell carcinoma of the uterine cervix: A case report.","volume":"13","author":"Zhao","year":"2020","journal-title":"Int J Clin Exp Pathol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/PAS.0000000000000543","article-title":"Invasive stratified mucin-producing carcinoma and Stratified Mucin-producing Intraepithelial Lesion (SMILE): 15 cases presenting a spectrum of cervical neoplasia with description of a distinctive variant of invasive adenocarcinoma.","volume":"40","author":"Lastra","year":"2016","journal-title":"Am J Surg Pathol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1097\/PAS.0000000000001480","article-title":"Invasive Stratified Mucin-producing Carcinoma (ISMC) of the cervix: A study on morphologic diversity.","volume":"44","author":"Stolnicu","year":"2020","journal-title":"Am J Surg Pathol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.oraloncology.2018.10.011","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma: An emerging tumor type with a unique microscopic appearance and a paradoxical clinical behaviour.","volume":"87","author":"Bishop","year":"2018","journal-title":"Oral Oncol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1507736\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T04:24:14Z","timestamp":1733372654000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2024.1507736\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":17,"alternative-id":["10.3389\/fmed.2024.1507736"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2024.1507736","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]},"article-number":"1507736"}}