{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:06:16Z","timestamp":1753891576700,"version":"3.41.2"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:italic>Ralstonia mannitolilytica<\/jats:italic> is a very rare pathogen that causes intracranial infection. It is commonly found in immunocompromised patients and is resistant to multiple antibiotics. In this case report, we present a case of human central nervous system infection caused by <jats:italic>Ralstonia mannitolilytica<\/jats:italic>, which was initially misdiagnosed as demyelinating disease due to the specific imaging findings. This case had concurrent uremia and a good response to meropenem under continuous peritoneal dialysis. The diagnosis is mainly based on cerebrospinal fluid analysis and targeted genetic testing by next generation sequencing (NGS). However, the patient had a poor prognosis due to uncontrollable gastrointestinal bleeding and related complications during long-term bed rest. We hope that this case will attract more attention and provide relevant reference for the diagnosis and treatment of other similar patients.<\/jats:p>","DOI":"10.3389\/fmed.2024.1513771","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T05:10:27Z","timestamp":1736831427000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: special imaging features in a uremic patient with intracranial infection caused by Ralstonia mannitolilytica, almost misdiagnosed as demyelinating disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Hanxin","family":"Kong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"B1","first-page":"374","article-title":"Ralstonia mannitolilytica bacteraemia: A case report and literature review.","volume":"26","author":"Boattini","year":"2018","journal-title":"Infez Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.2147\/IDR.S206492","article-title":"A case of persistent bacteraemia by Ralstonia mannitolilytica and Ralstonia pickettii in an intensive care unit.","volume":"12","author":"Basso","year":"2019","journal-title":"Infect 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