{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:47:27Z","timestamp":1780757247678,"version":"3.54.1"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Inflammatory myofibroblastic tumor (IMT) is a rare low-grade malignant neoplasm in the liver. Timely diagnosis and treatment of IMT are challenging due to its atypical symptoms and imaging results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>We report a 46-year-old woman who presented to our hospital with persistent hyperpyrexia and discomfort in the right upper abdomen for 2\u202fmonths post bone marrow transplantation. Radiological findings revealed a space-occupying lesion of uncertain nature in the liver. Since the histological examination of the biopsy specimen indicated IMT, she underwent surgical resection. Subsequently, the postoperative pathology confirmed the diagnosis of IMT. The patient\u2019s febrile condition subsided after the surgery. A magnetic resonance imaging (MRI) scan performed 8\u202fmonths later showed no signs of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IMTs are caused by genetic rearrangements. Diagnosing IMT can be challenging especially in this case as we had to differentiate the tumor from inflammatory diseases associated with bone marrow transplantation. Hence, a thorough pathological immunohistochemical examination is required to confirm its diagnosis. Local IMTs should be treated with radical surgical resection. In cases of distant metastasis or incomplete resection cases, chemotherapy, targeted therapy, or immunotherapy can be utilized. Regular follow-up is crucial for improving the patient\u2019s survival rate.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1489399","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:23:54Z","timestamp":1742801034000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Inflammatory myofibroblastic tumor in the liver after bone marrow transplantation: case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Shuhui","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"100768","DOI":"10.1016\/j.currproblcancer.2021.100768","article-title":"Inflammatory myofibroblastic tumor: molecular landscape, targeted therapeutics, and remaining challenges","volume":"45","author":"Mahajan","year":"2021","journal-title":"Curr Probl cancer"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ejca.2019.12.021","article-title":"Inflammatory myofibroblastic tumor: the experience of the European pediatric Soft Tissue Sarcoma Study Group (EpSSG)","volume":"127","author":"Casanova","year":"2020","journal-title":"Eur J Cancer"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.32604\/or.2024.050350","article-title":"Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment","volume":"32","author":"Chmiel","year":"2024","journal-title":"Oncol Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e59359","DOI":"10.7759\/cureus.59359","article-title":"Inflammatory myofibroblastic tumor after receiving treatment for non-small cell carcinoma","volume":"16","author":"Parker","year":"2024","journal-title":"Cureus"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.32074\/1591-951X-213","article-title":"The 2020 WHO classification of soft tissue tumours: news and perspectives","volume":"113","author":"Sbaraglia","year":"2020","journal-title":"Pathologica"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1097\/PAS.0000000000000404","article-title":"Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement","volume":"39","author":"Antonescu","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s10637-019-00742-2","article-title":"Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1-ALK fusion: a case report","volume":"37","author":"Honda","year":"2019","journal-title":"Investig New Drugs"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1111\/his.14010","article-title":"Diagnostic utility of pan-Trk immunohistochemistry for inflammatory myofibroblastic tumours","volume":"76","author":"Yamamoto","year":"2020","journal-title":"Histopathology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1002\/jcp.10472","article-title":"Anaplastic lymphoma kinase proteins in growth control and cancer","volume":"199","author":"Pulford","year":"2004","journal-title":"J Cell Physiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/modpathol.2014.165","article-title":"Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors","volume":"28","author":"Hornick","year":"2015","journal-title":"Mod Pathol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/his.12910","article-title":"ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumours","volume":"69","author":"Yamamoto","year":"2016","journal-title":"Histopathology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1177\/1066896914525232","article-title":"ALK-positive inflammatory myofibroblastic tumor of the abdomen with widespread microscopic multifocality","volume":"22","author":"Lorenzi","year":"2014","journal-title":"Int J Surg Pathol"},{"key":"ref13","first-page":"448","article-title":"A rare case of fever of unknown origin: inflammatory myofibroblastic tumor of the liver. 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