{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:06:35Z","timestamp":1769079995604,"version":"3.49.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>5-hydroxytryptamine 3 (5-HT3) receptor antagonists have been reported to reduce post-spinal anesthesia hypotension, though their efficacy remains controversial. We investigated the effect of prophylactic ondansetron on hemodynamic stability in patients undergoing cesarean section following spinal anesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients scheduled for elective cesarean section (<jats:italic>n<\/jats:italic>\u202f=\u202f120) were randomly allocated to three groups (NS group, 4\u202fmg group, 8\u202fmg group) of 40: those given 4\u202fmL of normal saline (NS), and those given either 4\u202fmg or 8\u202fmg ondansetron (4\u202fmL) before spinal anesthesia. Patient information, maternal systolic blood pressure stability [median performance error (MDPE), median absolute performance error (MDAPE)], the incidence of post-spinal anesthesia hypotension, norepinephrine doses, other adverse events (severe post-spinal anesthesia hypotension, nausea, vomiting, bradycardia, and hypertension), umbilical artery blood gas values, and infant Apgar scores were all recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary outcomes (median performance error, MDPE and median absolute performance error, MDAPE) were significantly different among the three groups. (<jats:italic>p<\/jats:italic>\u202f=\u202f0.001, <jats:italic>p<\/jats:italic>\u202f=\u202f0.002). Compared with the NS group, systolic blood pressure (SBP) was maintained closer to baseline in the 4\u202fmg group (<jats:italic>p<\/jats:italic>\u202f=\u202f0.003, <jats:italic>p<\/jats:italic>\u202f=\u202f0.006), as was the 8\u202fmg group (<jats:italic>p<\/jats:italic>\u202f=\u202f0.011, <jats:italic>p<\/jats:italic>\u202f=\u202f0.006). There was a significant difference in the incidence of post-spinal anesthesia hypotension among the three groups (<jats:italic>p<\/jats:italic>\u202f=\u202f0.002). However, only there was a statistical difference between NS and the 8\u202fmg groups in pairwise comparisons (<jats:italic>p<\/jats:italic>\u202f=\u202f0.001). The doses of norepinephrine, the incidences of other adverse events, umbilical artery blood gas, and Apgar scores were not statistically different between the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prophylactic 4\u202fmg or 8\u202fmg ondansetron improved hemodynamic stability after spinal anesthesia in cesarean section; however, only 8\u202fmg reduced post-spinal anesthesia hypotension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p><jats:uri>Clinicaltrials.gov<\/jats:uri>, NCT05475873.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1495721","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T06:13:17Z","timestamp":1743660797000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of different prophylactical doses of ondansetron for the hemodynamic stability in patients undergoing cesarean section: a randomized controlled study"],"prefix":"10.3389","volume":"12","author":[{"given":"Rui","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangzhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinli","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1016\/j.bja.2019.09.045","article-title":"Vasopressor 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