{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:01:36Z","timestamp":1753891296305,"version":"3.41.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>This case study describes a middle-aged male patient who developed persistent hypernatremia due to central diabetes insipidus (CDI), presenting with polyuria (up to 8.5 L\/24 h), polydipsia, and hypotonic urine (urine specific gravity &amp;lt; 1.005). A positive response to the desmopressin test confirmed the diagnosis of CDI. The excessive loss of body water led to a peak serum sodium level of 195 mmol\/L, resulting in Osmotic demyelination syndrome (ODS), clinically manifesting as sluggish responses and symmetrical limb paralysis. The patient was treated with hypotonic fluid replacement combined with desmopressin while ensuring a controlled reduction in serum sodium levels (\u226410 mmol\/L within 24 h). As a result, as serum sodium and urine output gradually normalized, the patient\u2019s consciousness and limb strength progressively recovered. This case highlights the risk of ODS in patients with severe hypernatremia caused by CDI. A slow and controlled correction of serum sodium levels is crucial in preventing cerebral edema, and early rehabilitation plays a vital role in improving neurological outcomes.<\/jats:p>","DOI":"10.3389\/fmed.2025.1498731","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T05:39:55Z","timestamp":1745991595000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Rapid-onset hypernatremia induced by central diabetes insipidus leading to osmotic demyelination syndrome: a case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Yifan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangxu","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.1016\/j.eprac.2023.03.183","article-title":"Abstract #1408214: Severe hypernatremia due to central diabetes insipidus with adipsia: Challenges in management.","volume":"29","author":"Lamichhane","year":"2023","journal-title":"Endocrine Pract."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/s0140-6736(67)93022-x","article-title":"Prognosis of the neurological complications of acute hypernatraemia.","volume":"2","author":"Morris-Jones","year":"1967","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.beem.2015.04.012","article-title":"Best practice; Research clinical endocrinology & metabolism. 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