{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:39:09Z","timestamp":1769553549556,"version":"3.49.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Paraneoplastic pemphigus (PNP) is a rare and potentially fatal autoimmune disease that primarily affects the mucocutaneous tissues. Here we present the clinical features of a patient with the lichenoid variant of PNP involving the oral mucosa only. The patient exhibited clinical manifestations resembling both lichen planus and pemphigus, yet these lesions remained unresponsive to corticosteroid therapy. A chest computed tomography (CT) scan revealed Castleman disease. Following surgical removal of the tumor, the patient\u2019s oral mucosa healed completely, with no recurrence observed in a 4-year follow-up period. These findings emphasize the importance of considering PNP as a potential diagnosis in patients with refractory oral erosions displaying lichen planus-like and pemphigus-like features, particularly when unresponsive to corticosteroid therapy. A thoracic-abdominal-pelvic CT scan is recommended to facilitate accurate diagnosis and appropriate treatment.<\/jats:p>","DOI":"10.3389\/fmed.2025.1498800","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T05:14:50Z","timestamp":1737954890000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Paraneoplastic pemphigus involved oral mucosa only: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Xixi","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1111\/jdv.18931","article-title":"S2k guidelines on the management of paraneoplastic pemphigus\/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV).","volume":"37","author":"Antiga","year":"2023","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3673","article-title":"Features and risk factors for paraneoplastic autoimmune multiorgan syndrome in 145 Chinese patients.","volume":"100","author":"Wang","year":"2020","journal-title":"Acta Derm Venereol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122532","article-title":"Paraneoplastic pemphigus: Insight into the autoimmune pathogenesis, clinical features and therapy.","volume":"18","author":"Paolino","year":"2017","journal-title":"Int J Mol Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"410","DOI":"10.2340\/00015555-0446","article-title":"Paraneoplastic pemphigus developed shortly after resection of follicular dendritic cell sarcoma.","volume":"88","author":"Lee","year":"2008","journal-title":"Acta Derm Venereol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1056\/nejm199012203232503","article-title":"Paraneoplastic pemphigus. 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