{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:56:08Z","timestamp":1769828168508,"version":"3.49.0"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Hypoglossal nerve stimulation therapy via the Inspire\u00ae implant is a common alternative to positive airway pressure (PAP) treatment for obstructive sleep apnea (OSA). While hypoglossal nerve stimulation (HGNS) therapy offers a high rate of successful treatment outcomes, the post-activation care pathway, which involves gradual titration of the amplitude to achieve both subjective and objective improvements, can be lengthy, ranging from 3 to 12\u202fmonths post-activation. Here, we report a case of a 55-year-old man with severe obstructive sleep apnea and a history of hypertension who underwent successful activation and titration of the Inspire\u00ae implant to achieve subjective and objective relief within 8\u202fweeks post-implantation and 5\u202fweeks post-activation, using an unconventional starting electrode configuration. This case highlights the need for further exploration of alternative Inspire\u00ae activation and management protocols that may lead to improved patient outcomes and higher success rates.<\/jats:p>","DOI":"10.3389\/fmed.2025.1501242","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T05:20:38Z","timestamp":1740633638000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The activation, clinical course, and clinical outcome of using an unconventional electrode configuration in a patient newly implanted with Inspire\u00ae therapy: a case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Ruchir P.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsie E.","family":"Rohrscheib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s11325-019-01923-2","article-title":"Hypoglossal nerve stimulation long-term clinical outcomes: a systematic review and meta-analysis","volume":"24","author":"Costantino","year":"2020","journal-title":"Sleep Breath"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"220164","DOI":"10.1183\/20734735.0164-2022","article-title":"Non-CPAP therapy for obstructive sleep apnoea","volume":"18","author":"Verbraecken","year":"2022","journal-title":"Breathe (Sheff)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1111\/ner.13490","article-title":"Impulse configuration in hypoglossal nerve stimulation in obstructive sleep apnea: the effect of modifying pulse width and frequency","volume":"25","author":"Steffen","year":"2022","journal-title":"Neuromodulation"},{"key":"ref4","year":"2023"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3389\/fnins.2017.00523","article-title":"Development of a clinical pathway and technical aspects of upper airway stimulation therapy for obstructive sleep apnea","volume":"11","author":"Vanderveken","year":"2017","journal-title":"Front Neurosci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1056\/NEJMoa1308659","article-title":"Upper-airway stimulation for obstructive sleep apnea","volume":"370","author":"Strollo","year":"2014","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.5664\/jcsm.10644","article-title":"Evaluation of a novel device to assess obstructive sleep apnea and body position","volume":"19","author":"Raphelson","year":"2023","journal-title":"J Clin Sleep Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1016\/j.chest.2018.08.1070","article-title":"Neurostimulation treatment of OSA","volume":"154","author":"Fleury Curado","year":"2018","journal-title":"Chest"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1501242\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T05:20:41Z","timestamp":1740633641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1501242\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":8,"alternative-id":["10.3389\/fmed.2025.1501242"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1501242","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,27]]},"article-number":"1501242"}}